Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06-25

AUTHORS

Tuomas Tammela, Georgia Zarkada, Elisabet Wallgard, Aino Murtomäki, Steven Suchting, Maria Wirzenius, Marika Waltari, Mats Hellström, Tibor Schomber, Reetta Peltonen, Catarina Freitas, Antonio Duarte, Helena Isoniemi, Pirjo Laakkonen, Gerhard Christofori, Seppo Ylä-Herttuala, Masabumi Shibuya, Bronislaw Pytowski, Anne Eichmann, Christer Betsholtz, Kari Alitalo

ABSTRACT

Anti-angiogenesis: VEGFR-3 shows its pacesThe vascular endothelial growth factor (VEGF) receptor subtype VEGFR-3 is expressed only on lymphatic endothelium in adults. A new study, however, finds that VEGFR-3 is upregulated in the vasculature of tumours by Notch signalling. VEGFR-3 inhibition interferes with tumour angiogenesis and tumour growth, in particular in combination with inhibitors of VEGFR-2, suggesting that it represents a novel anti-angiogenic target for cancer therapy. More... »

PAGES

656-660

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

7204

VOLUME

454

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature07083

DOI

http://dx.doi.org/10.1038/nature07083

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007540186

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18594512


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