IRF4 addiction in multiple myeloma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-06-22

AUTHORS

Arthur L. Shaffer, N. C. Tolga Emre, Laurence Lamy, Vu N. Ngo, George Wright, Wenming Xiao, John Powell, Sandeep Dave, Xin Yu, Hong Zhao, Yuxin Zeng, Bangzheng Chen, Joshua Epstein, Louis M. Staudt

ABSTRACT

IRF4 dependency in myeloma cellsAn RNA interference scan for genes linked to the proliferation of myeloma cell lines as possible drug targets has identified the transcription factor factor IRF4, needed for lymphocyte activation and plasma cell differentiation in normal cells, as a master regulator of multiple myeloma. Strikingly, myeloma cells are completely dependent on IRF4, despite that fact that most do not harbour mutations, translocations or amplifications of the IRF4 locus. In cancer cells, IRF4 controls a different network of genes — including the MYC oncogene — than in normal plasma cells or activated B cells. IRF4 dependency in myeloma is an example of 'non-oncogene addiction', where cancer cells depend on a normal cellular protein for proliferation and/or survival. More... »

PAGES

226-231

Journal

TITLE

Nature

ISSUE

7201

VOLUME

454

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature07064

DOI

http://dx.doi.org/10.1038/nature07064

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038937039

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18568025


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32 schema:description IRF4 dependency in myeloma cellsAn RNA interference scan for genes linked to the proliferation of myeloma cell lines as possible drug targets has identified the transcription factor factor IRF4, needed for lymphocyte activation and plasma cell differentiation in normal cells, as a master regulator of multiple myeloma. Strikingly, myeloma cells are completely dependent on IRF4, despite that fact that most do not harbour mutations, translocations or amplifications of the IRF4 locus. In cancer cells, IRF4 controls a different network of genes — including the MYC oncogene — than in normal plasma cells or activated B cells. IRF4 dependency in myeloma is an example of 'non-oncogene addiction', where cancer cells depend on a normal cellular protein for proliferation and/or survival.
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39 IRF4
40 MYC oncogene
41 activation
42 addiction
43 amplification
44 cancer cells
45 cell differentiation
46 cell lines
47 cells
48 cellular proteins
49 dependency
50 different networks
51 differentiation
52 drug targets
53 example
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55 genes
56 lines
57 loci
58 lymphocyte activation
59 master regulator
60 multiple myeloma
61 mutations
62 myeloma
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66 non-oncogene addiction
67 normal cells
68 normal cellular protein
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71 plasma cell differentiation
72 plasma cells
73 possible drug targets
74 proliferation
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