Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-05-07

AUTHORS

Wei Guo, Joseph L. Lasky, Chun-Ju Chang, Sherly Mosessian, Xiaoman Lewis, Yun Xiao, Jennifer E. Yeh, James Y. Chen, M. Luisa Iruela-Arispe, Marileila Varella-Garcia, Hong Wu

ABSTRACT

Cancer model: Pten deletion mimics acute T lymphoblastic leukaemiaA new leukaemia model has been established in mice by deleting the Pten tumour suppressor gene in fetal liver haematopoietic stem cells. The mice develop a myeloproliferative disorder that can lead to acute T lymphoblastic leukaemia. Progression of the condition is driven by leukaemia stem cells that require beta-catenin and incorporate a translocation that leads to overexpression of the c-myc oncogene, similar to findings in human acute T lymphoblastic leukaemia. The study illustrates how multiple genetic alterations can dictate hyperproliferative disorders and the progression to cancer. More... »

PAGES

529-533

Journal

TITLE

Nature

ISSUE

7194

VOLUME

453

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature06933

DOI

http://dx.doi.org/10.1038/nature06933

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014788446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18463637


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