Life without RNase P View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-05

AUTHORS

Lennart Randau, Imke Schröder, Dieter Söll

ABSTRACT

The universality of ribonuclease P (RNase P), the ribonucleoprotein essential for transfer RNA (tRNA) 5' maturation, is challenged in the archaeon Nanoarchaeum equitans. Neither extensive computational analysis of the genome nor biochemical tests in cell extracts revealed the existence of this enzyme. Here we show that the conserved placement of its tRNA gene promoters allows the synthesis of leaderless tRNAs, whose presence was verified by the observation of 5' triphosphorylated mature tRNA species. Initiation of tRNA gene transcription requires a purine, which coincides with the finding that tRNAs with a cytosine in position 1 display unusually extended 5' termini with an extra purine residue. These tRNAs were shown to be substrates for their cognate aminoacyl-tRNA synthetases. These findings demonstrate how nature can cope with the loss of the universal and supposedly ancient RNase P through genomic rearrangement at tRNA genes under the pressure of genome condensation. More... »

PAGES

120

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature06833

DOI

http://dx.doi.org/10.1038/nature06833

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035908939

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18451863


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acyl-tRNA Synthetases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aminoacylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Archaeal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanoarchaeota", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Archaeal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Transfer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribonuclease P", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Molecular Biophysics and Biochemistry,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Randau", 
        "givenName": "Lennart", 
        "id": "sg:person.0673250663.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673250663.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schr\u00f6der", 
        "givenName": "Imke", 
        "id": "sg:person.01270166556.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270166556.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Molecular Biophysics and Biochemistry,", 
            "Department of Chemistry, Yale University, New Haven, Connecticut 06520-8114, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00f6ll", 
        "givenName": "Dieter", 
        "id": "sg:person.012067245622.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012067245622.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0509197102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000481884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0320222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000921373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0320222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000921373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.241636498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004091279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.14.7803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006586238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-7-186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011138546", 
          "https://doi.org/10.1186/1471-2164-7-186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1735403100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012085657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016211745", 
          "https://doi.org/10.1038/nature03233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016211745", 
          "https://doi.org/10.1038/nature03233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.849004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016890117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.8.4248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020818528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(83)90117-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022283156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029733276", 
          "https://doi.org/10.1038/nsb934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029733276", 
          "https://doi.org/10.1038/nsb934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(98)01096-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031099945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10409230600602634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031516175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(89)90030-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032612499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(89)90030-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032612499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2006.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033993400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.72.12.4790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038396509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.112063799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040956624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/18.1.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042370979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0607326104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042501913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044306591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2003.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046663620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2003.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046663620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0608000103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046924979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pep.2005.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048782637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.7970404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049777960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-9084(02)01447-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050733280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1355838202022021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054923762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi035708f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055197989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi035708f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055197989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.177.7.1844-1849.1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062724639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081646825", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081936013", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.7.1.7916700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082563999"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-05", 
    "datePublishedReg": "2008-05-01", 
    "description": "The universality of ribonuclease P (RNase P), the ribonucleoprotein essential for transfer RNA (tRNA) 5' maturation, is challenged in the archaeon Nanoarchaeum equitans. Neither extensive computational analysis of the genome nor biochemical tests in cell extracts revealed the existence of this enzyme. Here we show that the conserved placement of its tRNA gene promoters allows the synthesis of leaderless tRNAs, whose presence was verified by the observation of 5' triphosphorylated mature tRNA species. Initiation of tRNA gene transcription requires a purine, which coincides with the finding that tRNAs with a cytosine in position 1 display unusually extended 5' termini with an extra purine residue. These tRNAs were shown to be substrates for their cognate aminoacyl-tRNA synthetases. These findings demonstrate how nature can cope with the loss of the universal and supposedly ancient RNase P through genomic rearrangement at tRNA genes under the pressure of genome condensation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature06833", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7191", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "453"
      }
    ], 
    "name": "Life without RNase P", 
    "pagination": "120", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ab0f03a141cc1c7ab77b81e32a992c506c16a29295fe8482cbc070aa47e52f26"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18451863"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature06833"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035908939"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature06833", 
      "https://app.dimensions.ai/details/publication/pub.1035908939"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature06833"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature06833'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature06833'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature06833'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature06833'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      76 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature06833 schema:about N12bb5aa3144d45e9ade7947b570bd56e
2 N1bab96223fe44a4a9027641b505b4752
3 N24b7578277da45d596187a96e97446b1
4 N25d1ae40c0dd4f1f8a1c85fc375acebb
5 N311cb88f1bf34029bed98715cca5fd5b
6 N50412dced5e34184b78aa4c96ca19c54
7 N716c9ec670374cfeb7700a89f0a9903c
8 N778727b36483445f98705178a90930da
9 N7ac235e77fe848aabe0607d73909abfd
10 N8ffff515fd05430f815c555db5350bf9
11 Nafce211f8e13432f842b061383edf799
12 Nc8e2935860294621b2fa8df95554d557
13 Nd7649a95a1714f7fa1ebec45c5bf4d62
14 Ne1ce2a0297eb452a84b496fb6256c082
15 Ne56311ccef524e44a9bb9dd6e1152ac7
16 Nf5dfe63288fd4fd8bd5f4d03280b18e1
17 anzsrc-for:06
18 anzsrc-for:0604
19 schema:author N31dacd4cd7d14ba0a2bc79c0e2272105
20 schema:citation sg:pub.10.1038/nature03233
21 sg:pub.10.1038/nsb934
22 sg:pub.10.1186/1471-2164-7-186
23 https://app.dimensions.ai/details/publication/pub.1081646825
24 https://app.dimensions.ai/details/publication/pub.1081936013
25 https://doi.org/10.1016/0092-8674(83)90117-4
26 https://doi.org/10.1016/0378-1119(89)90030-9
27 https://doi.org/10.1016/j.pep.2005.01.016
28 https://doi.org/10.1016/j.tibs.2006.04.007
29 https://doi.org/10.1016/j.tig.2003.08.007
30 https://doi.org/10.1016/s0014-5793(98)01096-5
31 https://doi.org/10.1016/s0300-9084(02)01447-5
32 https://doi.org/10.1017/s1355838202022021
33 https://doi.org/10.1021/bi035708f
34 https://doi.org/10.1042/bst0320222
35 https://doi.org/10.1073/pnas.0509197102
36 https://doi.org/10.1073/pnas.0607326104
37 https://doi.org/10.1073/pnas.0608000103
38 https://doi.org/10.1073/pnas.112063799
39 https://doi.org/10.1073/pnas.1735403100
40 https://doi.org/10.1073/pnas.241636498
41 https://doi.org/10.1073/pnas.72.12.4790
42 https://doi.org/10.1073/pnas.96.14.7803
43 https://doi.org/10.1080/10409230600602634
44 https://doi.org/10.1093/nar/18.1.83
45 https://doi.org/10.1093/nar/gki012
46 https://doi.org/10.1096/fasebj.7.1.7916700
47 https://doi.org/10.1101/gr.849004
48 https://doi.org/10.1128/jb.177.7.1844-1849.1995
49 https://doi.org/10.1128/mcb.16.8.4248
50 https://doi.org/10.1261/rna.7970404
51 schema:datePublished 2008-05
52 schema:datePublishedReg 2008-05-01
53 schema:description The universality of ribonuclease P (RNase P), the ribonucleoprotein essential for transfer RNA (tRNA) 5' maturation, is challenged in the archaeon Nanoarchaeum equitans. Neither extensive computational analysis of the genome nor biochemical tests in cell extracts revealed the existence of this enzyme. Here we show that the conserved placement of its tRNA gene promoters allows the synthesis of leaderless tRNAs, whose presence was verified by the observation of 5' triphosphorylated mature tRNA species. Initiation of tRNA gene transcription requires a purine, which coincides with the finding that tRNAs with a cytosine in position 1 display unusually extended 5' termini with an extra purine residue. These tRNAs were shown to be substrates for their cognate aminoacyl-tRNA synthetases. These findings demonstrate how nature can cope with the loss of the universal and supposedly ancient RNase P through genomic rearrangement at tRNA genes under the pressure of genome condensation.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N5a78adc2c0e84695845734e92dad6543
58 Nddf93180e1124e5db52526636fa18bea
59 sg:journal.1018957
60 schema:name Life without RNase P
61 schema:pagination 120
62 schema:productId N2b2cdf85953d4aaebfe97f64da9905fb
63 N3b592cadf0234f8cb99fae12f4c74836
64 Ncb35f9a215a34af6ad1651e7f8fc75ce
65 Ned6ca69a4f1248e5875136b85ccb4cf1
66 Nff407c31f16b410ea6cc68ab28c91f30
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035908939
68 https://doi.org/10.1038/nature06833
69 schema:sdDatePublished 2019-04-10T18:08
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N7f853252365c4f428e8c35b708aa40f0
72 schema:url https://www.nature.com/articles/nature06833
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N12bb5aa3144d45e9ade7947b570bd56e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name RNA, Archaeal
78 rdf:type schema:DefinedTerm
79 N1bab96223fe44a4a9027641b505b4752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Base Sequence
81 rdf:type schema:DefinedTerm
82 N24b7578277da45d596187a96e97446b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Promoter Regions, Genetic
84 rdf:type schema:DefinedTerm
85 N25d1ae40c0dd4f1f8a1c85fc375acebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Gene Deletion
87 rdf:type schema:DefinedTerm
88 N2b2cdf85953d4aaebfe97f64da9905fb schema:name doi
89 schema:value 10.1038/nature06833
90 rdf:type schema:PropertyValue
91 N311cb88f1bf34029bed98715cca5fd5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Models, Biological
93 rdf:type schema:DefinedTerm
94 N31dacd4cd7d14ba0a2bc79c0e2272105 rdf:first sg:person.0673250663.02
95 rdf:rest N4b19f95994604bd594a5f1c4abd68dc5
96 N3b592cadf0234f8cb99fae12f4c74836 schema:name dimensions_id
97 schema:value pub.1035908939
98 rdf:type schema:PropertyValue
99 N3ea84650b7d0426a940bd87963a01d5e rdf:first sg:person.012067245622.45
100 rdf:rest rdf:nil
101 N4b19f95994604bd594a5f1c4abd68dc5 rdf:first sg:person.01270166556.64
102 rdf:rest N3ea84650b7d0426a940bd87963a01d5e
103 N50412dced5e34184b78aa4c96ca19c54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Aminoacylation
105 rdf:type schema:DefinedTerm
106 N5a78adc2c0e84695845734e92dad6543 schema:issueNumber 7191
107 rdf:type schema:PublicationIssue
108 N5fb8eb1a7287467ba958400f8c68908c schema:name Department of Molecular Biophysics and Biochemistry,
109 rdf:type schema:Organization
110 N716c9ec670374cfeb7700a89f0a9903c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Nanoarchaeota
112 rdf:type schema:DefinedTerm
113 N778727b36483445f98705178a90930da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Evolution, Molecular
115 rdf:type schema:DefinedTerm
116 N7ac235e77fe848aabe0607d73909abfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Substrate Specificity
118 rdf:type schema:DefinedTerm
119 N7f853252365c4f428e8c35b708aa40f0 schema:name Springer Nature - SN SciGraph project
120 rdf:type schema:Organization
121 N8ffff515fd05430f815c555db5350bf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name RNA, Transfer
123 rdf:type schema:DefinedTerm
124 Nafce211f8e13432f842b061383edf799 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Molecular Sequence Data
126 rdf:type schema:DefinedTerm
127 Nc8e2935860294621b2fa8df95554d557 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Phosphorylation
129 rdf:type schema:DefinedTerm
130 Ncb35f9a215a34af6ad1651e7f8fc75ce schema:name pubmed_id
131 schema:value 18451863
132 rdf:type schema:PropertyValue
133 Nd7649a95a1714f7fa1ebec45c5bf4d62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Transcription, Genetic
135 rdf:type schema:DefinedTerm
136 Nddf93180e1124e5db52526636fa18bea schema:volumeNumber 453
137 rdf:type schema:PublicationVolume
138 Ne1ce2a0297eb452a84b496fb6256c082 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Ribonuclease P
140 rdf:type schema:DefinedTerm
141 Ne56311ccef524e44a9bb9dd6e1152ac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Genes, Archaeal
143 rdf:type schema:DefinedTerm
144 Ned6ca69a4f1248e5875136b85ccb4cf1 schema:name nlm_unique_id
145 schema:value 0410462
146 rdf:type schema:PropertyValue
147 Nf5dfe63288fd4fd8bd5f4d03280b18e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Amino Acyl-tRNA Synthetases
149 rdf:type schema:DefinedTerm
150 Nff407c31f16b410ea6cc68ab28c91f30 schema:name readcube_id
151 schema:value ab0f03a141cc1c7ab77b81e32a992c506c16a29295fe8482cbc070aa47e52f26
152 rdf:type schema:PropertyValue
153 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
154 schema:name Biological Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
157 schema:name Genetics
158 rdf:type schema:DefinedTerm
159 sg:journal.1018957 schema:issn 0090-0028
160 1476-4687
161 schema:name Nature
162 rdf:type schema:Periodical
163 sg:person.012067245622.45 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
164 schema:familyName Söll
165 schema:givenName Dieter
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012067245622.45
167 rdf:type schema:Person
168 sg:person.01270166556.64 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
169 schema:familyName Schröder
170 schema:givenName Imke
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270166556.64
172 rdf:type schema:Person
173 sg:person.0673250663.02 schema:affiliation N5fb8eb1a7287467ba958400f8c68908c
174 schema:familyName Randau
175 schema:givenName Lennart
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673250663.02
177 rdf:type schema:Person
178 sg:pub.10.1038/nature03233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016211745
179 https://doi.org/10.1038/nature03233
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nsb934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029733276
182 https://doi.org/10.1038/nsb934
183 rdf:type schema:CreativeWork
184 sg:pub.10.1186/1471-2164-7-186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011138546
185 https://doi.org/10.1186/1471-2164-7-186
186 rdf:type schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1081646825 schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1081936013 schema:CreativeWork
189 https://doi.org/10.1016/0092-8674(83)90117-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022283156
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0378-1119(89)90030-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032612499
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.pep.2005.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048782637
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.tibs.2006.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033993400
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.tig.2003.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046663620
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0014-5793(98)01096-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031099945
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s0300-9084(02)01447-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050733280
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1017/s1355838202022021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054923762
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1021/bi035708f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055197989
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1042/bst0320222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000921373
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1073/pnas.0509197102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000481884
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1073/pnas.0607326104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042501913
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1073/pnas.0608000103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046924979
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1073/pnas.112063799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040956624
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1073/pnas.1735403100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012085657
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1073/pnas.241636498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004091279
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1073/pnas.72.12.4790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038396509
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.96.14.7803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006586238
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1080/10409230600602634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031516175
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1093/nar/18.1.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042370979
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/nar/gki012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044306591
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1096/fasebj.7.1.7916700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082563999
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1101/gr.849004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016890117
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1128/jb.177.7.1844-1849.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062724639
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1128/mcb.16.8.4248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020818528
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1261/rna.7970404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049777960
240 rdf:type schema:CreativeWork
241 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
242 schema:name Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095, USA
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
245 schema:name Department of Chemistry, Yale University, New Haven, Connecticut 06520-8114, USA
246 Department of Molecular Biophysics and Biochemistry,
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...