Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02-17

AUTHORS

Shawn J. Cokus, Suhua Feng, Xiaoyu Zhang, Zugen Chen, Barry Merriman, Christian D. Haudenschild, Sriharsa Pradhan, Stanley F. Nelson, Matteo Pellegrini, Steven E. Jacobsen

ABSTRACT

Mapping the methylomeA newly developed method of characterizing an organism's 'methylome', that is the pattern of DNA methylation in the genome, has been used to generate a map of methylated cytosines in Arabidopsis to single base-pair resolution. The procedure, termed BS-Seq, combines bisulphite treatment of genomic DNA with ultra-high-throughput DNA sequencing to achieve a more precise and comprehensive result than previously possible. DNA methylation is an important factor in regulating gene expression, and this method, which can be applied to larger genomes like the mouse as well as to Arabidopsis, could prove a significant advance in the study of this form of gene regulation. More... »

PAGES

215-219

Journal

TITLE

Nature

ISSUE

7184

VOLUME

452

Related Patents

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature06745

DOI

http://dx.doi.org/10.1038/nature06745

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015143631

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18278030


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