Ontology type: schema:ScholarlyArticle
2008-03
AUTHORSNobuhiro Nakao, Hiroko Ono, Takashi Yamamura, Tsubasa Anraku, Tsuyoshi Takagi, Kumiko Higashi, Shinobu Yasuo, Yasuhiro Katou, Saburo Kageyama, Yumiko Uno, Takeya Kasukawa, Masayuki Iigo, Peter J. Sharp, Atsushi Iwasawa, Yutaka Suzuki, Sumio Sugano, Teruyuki Niimi, Makoto Mizutani, Takao Namikawa, Shizufumi Ebihara, Hiroki R. Ueda, Takashi Yoshimura
ABSTRACTMolecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica) is the earliest event yet recorded in the photoperiodic signal transduction pathway. Here we show cascades of gene expression in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone. We identified two waves of gene expression. The first was initiated about 14 h after dawn of the first long day and included increased thyrotrophin (TSH) β-subunit expression in the pars tuberalis; the second occurred approximately 4 h later and included increased expression of DIO2. Intracerebroventricular (ICV) administration of TSH to short-day quail stimulated gonadal growth and expression of DIO2 which was shown to be mediated through a TSH receptor–cyclic AMP (cAMP) signalling pathway. Increased TSH in the pars tuberalis therefore seems to trigger long-day photoinduced seasonal breeding. More... »
PAGES317-322
http://scigraph.springernature.com/pub.10.1038/nature06738
DOIhttp://dx.doi.org/10.1038/nature06738
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1045763209
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18354476
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"description": "Molecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica) is the earliest event yet recorded in the photoperiodic signal transduction pathway. Here we show cascades of gene expression in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone. We identified two waves of gene expression. The first was initiated about 14\u2009h after dawn of the first long day and included increased thyrotrophin (TSH) \u03b2-subunit expression in the pars tuberalis; the second occurred approximately 4\u2009h later and included increased expression of DIO2. Intracerebroventricular (ICV) administration of TSH to short-day quail stimulated gonadal growth and expression of DIO2 which was shown to be mediated through a TSH receptor\u2013cyclic AMP (cAMP) signalling pathway. Increased TSH in the pars tuberalis therefore seems to trigger long-day photoinduced seasonal breeding.",
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"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7185",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "452"
}
],
"keywords": [
"expression of Dio2",
"gene expression",
"seasonal breeding",
"pars tuberalis",
"signal transduction pathways",
"first long day",
"transduction pathways",
"molecular mechanisms",
"photoperiodic response",
"gonadal growth",
"rapid induction",
"long days",
"breeding",
"early events",
"expression",
"tuberalis",
"DIO2",
"subunit expression",
"pathway",
"short day quail",
"mediobasal hypothalamus",
"Japanese quail",
"quail",
"enzyme",
"photoperiod",
"cascade",
"induction",
"response",
"growth",
"secretion",
"mechanism",
"AMP",
"initiation",
"hormone",
"dawn",
"events",
"TSH",
"hypothalamus",
"days",
"thyrotrophin",
"administration",
"intracerebroventricular administration",
"waves",
"animal seasonal breeding",
"photoperiodic signal transduction pathway",
"quail MBH",
"thyrotrophin (TSH) \u03b2",
"TSH receptor\u2013cyclic AMP",
"receptor\u2013cyclic AMP"
],
"name": "Thyrotrophin in the pars tuberalis triggers photoperiodic response",
"pagination": "317-322",
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