Reprogramming of human somatic cells to pluripotency with defined factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

In-Hyun Park, Rui Zhao, Jason A. West, Akiko Yabuuchi, Hongguang Huo, Tan A. Ince, Paul H. Lerou, M. William Lensch, George Q. Daley

ABSTRACT

Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the organism. Embryonic stem cells are embryo-derived cell lines that retain pluripotency and represent invaluable tools for research into the mechanisms of tissue formation. Recently, murine fibroblasts have been reprogrammed directly to pluripotency by ectopic expression of four transcription factors (Oct4, Sox2, Klf4 and Myc) to yield induced pluripotent stem (iPS) cells. Using these same factors, we have derived iPS cells from fetal, neonatal and adult human primary cells, including dermal fibroblasts isolated from a skin biopsy of a healthy research subject. Human iPS cells resemble embryonic stem cells in morphology and gene expression and in the capacity to form teratomas in immune-deficient mice. These data demonstrate that defined factors can reprogramme human cells to pluripotency, and establish a method whereby patient-specific cells might be established in culture. More... »

PAGES

141

Journal

TITLE

Nature

ISSUE

7175

VOLUME

451

Author Affiliations

Related Patents

  • Generation Of Induced Pluripotent Stem Cells From Cord Blood
  • New Serum-Free Medium For Inducing Pluripotent Stem Cells Quickly With High Efficiency And Method Using Thereof
  • A Non-Viral System For The Generation Of Induced Pluripotent Stem (Ips) Cells
  • Induced Pluripotent Stem Cells Produced With Oct3/4, Klf4 And Sox2
  • Reprogramming A Cell By Inducing A Pluripotent Gene Through Use Of A Small Molecule Modulator
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Kit For Making Induced Pluripotent Stem Cells Using Modified Rnas
  • Reprogramming Of Somatic Cells
  • Pluripotent Cell Lines And Methods Of Use Thereof
  • Compositions And Methods For Generation Of Human Epithelial Stem Cells
  • Methods For Producing Enucleated Erythroid Cells Derived From Pluripotent Stem Cells
  • Induced Pluripotent Stem Cells With Synthetic Modified Rnas
  • Nuclear Reprogramming Factor Comprising Mirna And A Protein Factor
  • Engineered Nucleic Acids Encoding A Modified Erythropoietin And Their Expression
  • Method For Reprogramming Cells
  • Use Of Cellular Extracts For Obtaining Pluripotent Stem Cells
  • Method For Modulating Myelination
  • Methods Of Promoting Lymphangiogenesis
  • Detection Of Human Somatic Cell Reprogramming
  • Protein-Induced Pluripotent Cell Technology And Uses Thereof
  • Method For Production Of Reprogrammed Cell Using Chromosomally Unintegrated Virus Vector
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Modified Polynucleotides For Treating Galactosylceramidase Protein Deficiency
  • Assay For Mutations In Stem Cells And Their Derivatives
  • Modified Polynucleotides Encoding Granulysin
  • Method For Production Of Reprogrammed Cell Using Chromosomally Unintegrated Virus Vector
  • Isolated Mesenchymal Progenitor Cells And Extracellular Matrix Produced Thereby
  • Reprogrammation Of Eukaryotic Cells With Engineered Microvesicles
  • Methods And Products For Dedifferentiation Of Cells
  • Compositions, Kits, And Methods For Making Induced Pluripotent Stem Cells Using Synthetic Modified Rnas
  • Use Of Cellular Extracts For Obtaining Pluripotent Stem Cells
  • Downregulation Of Mir-7 For Promotion Of Beta Cell Differentiation And Insulin Production
  • Novel Methods And Culture Media For Culturing Pluripotent Stem Cells
  • Method Of Efficiently Establishing Induced Pluripotent Stem Cells
  • Methods Of Generating Corneal Cells And Cell Populations Comprising Same
  • Human Pluripotent Stem Cells Induced From Undifferentiated Stem Cells Derived From A Human Postnatal Tissue
  • Populations Of Neural Progenitor Cells And Methods Of Producing And Using Same
  • Induced Pluripotent Stem Cell Model Of Chronic Myeloid Leukemia Revealed Olfactomedin 4 As A Novel Therapeutic Target In Leukemia Stem Cells
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Detection Of Human Somatic Cell Reprogramming
  • Modified Polynucleotides Encoding Cited4
  • Modified Polynucleotides For The Production Of Nuclear Proteins
  • Modified Polynucleotides Encoding Septin-4
  • Efficient Method For Nuclear Reprogramming
  • Formulation For Regeneration Of Bone, Cartilage, Teeth, And Periodontium And Treatment Of Tumors And Cysts
  • Composition For Inducing Pluripotent Stem Cell, And Use Thereof
  • Large Scale Production Of Retinal Pigment Epithelial Cells
  • Media For Culturing Pluripotent Stem Cells
  • Kits Comprising Linear Dnas For Sustained Polypeptide Expression Using Synthetic, Modified Rnas
  • Preparation Of Retinal Pigment Epithelium Cells
  • Preparation Of Photoreceptors For The Treatment Of Retinal Diseases
  • Methods And Products For Dedifferentiation Of Cells
  • Populations Of Hematopoietic Progenitors And Methods Of Enriching Stem Cells Therefor
  • Modified Polynucleotides For Treating Protein Deficiency
  • Somatic Cell Reprogramming By Retroviral Vectors Encoding Oct3/4. Klf4, C-Myc And Sox2
  • Differentiation Into Brown Adipocytes
  • Ets2 And Mesp1 Generate Cardiac Progenitors From Fibroblasts
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides Encoding Apoptosis Inducing Factor 1
  • Induction Of Pluripotent Cells
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Reprogramming A Cell By Inducing A Pluripotent Gene Through Rna Interference
  • Methods And Compositions For Maintaining Genomic Stability In Cultured Stem Cells
  • Cell Compositions Derived From Dedifferentiated Reprogrammed Cells
  • Generation Of Neural Stem Cells And Motor Neurons
  • Method For Preparing Induced Paraxial Mesoderm Progenitor (Ipam) Cells And Their Use
  • Methods And Platforms For Drug Discovery Using Induced Pluripotent Stem Cells
  • Human Blood-Brain Endothelial Cells Derived From Pluripotent Stem Cells And Blood-Brain Barrier Model Thereof
  • Method For Production Of Pluripotent Stem Cell
  • Ets2 And Mesp1 Generate Cardiac Progenitors From Fibroblasts
  • Reprogramming Of Somatic Cells With Purified Proteins
  • Stem Cell Culture Medium And Method
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Culture Method Of Embryoid Bodies And/Or Neural Stem Cells Derived From Human Differentiated Cell-Derived Pluripotent Stem Cells
  • Bioartifical Lung
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Maintenance Of Genomic Stability In Cultured Stem Cells
  • Method For Preparing Induced Pluripotent Stem Cells And Culture Medium Used For Preparing Induced Pluripotent Stem Cells
  • Method For Production Of Pluripotent Stem Cell
  • Stem Cells And Uses Thereof
  • Polycistronic Vector For Human Induced Pluripotent Stem Cell Production
  • Production Of Reprogrammed Pluripotent Cells
  • Methods For The Production Of Ips Cells Using Epstein-Barr (Ebv)-Based Reprogramming Vectors
  • Modified Polynucleotides For The Production Of Proteins Associated With Human Disease
  • Generation Of Induced Pluripotent Stem (Ips) Cells
  • Formulation And Delivery Of Plga Microspheres
  • Compositions And Methods Of Altering Cholesterol Levels
  • Optimized Methods For Generation Of Cardiac Stem Cells From Cardiac Tissue And Their Use In Cardiac Therapy
  • Generation Of Induced Pluripotent Stem (Ips) Cells
  • Differentiated Cells Originating In Artificial Pluripotent Stem Cells
  • Modified Polynucleotides Encoding Copper Metabolism (Murr1) Domain Containing 1
  • Modified Polynucleotides Encoding Basic Helix-Loop-Helix Family Member E41
  • In Vitro Differentiation Of Pluripotent Stem Cells To Pancreatic Endoderm Cells (Pec) And Endocrine Cells
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Hemangio Colony Forming Cells And Non-Engrafting Hemangio Cells
  • Modified Polynucleotides For The Production Of Proteins
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Fingerprint For Cell Identity And Pluripotency
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Oncology-Related Proteins And Peptides
  • Providing Ipscs To A Customer
  • Modified Polynucleotides For The Production Of Oncology-Related Proteins And Peptides
  • Methods For Maturing Cardiomyocytes And Uses Thereof
  • Modified Polynucleotides For The Production Of G-Csf
  • Methods For The Production Of Ips Cells Using Non-Viral Approach
  • Detection Of Human Somatic Cell Reprogramming
  • Populations Of Pancreatic Progenitor Cells And Methods Of Isolating And Using Same
  • Nuclear Reprogramming Factor
  • Functional Genomics Assay For Characterizing Pluripotent Stem Cell Utility And Safety
  • Insulin Producing Cells Derived From Pluripotent Stem Cells
  • In Vitro Model Of Spinal Muscular Atrophy
  • Methods, Systems And Compositions Relating To Cell Conversion Via Protein-Induced In-Vivo Cell Reprogramming
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Hemangio-Colony Forming Cells
  • Induced Presomitic Mesoderm (Ipsm) Cells And Their Use
  • Terminally Modified Rna
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Pericyte Progenitor Cells And Methods Of Generating And Using Same
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Compositions For Mesoderm Derived Isl1+ Multipotent Cells (Imps), Epicardial Progenitor Cells (Epcs) And Multipotent C56c Cells (C56cs) And Methods Of Producing And Using Same
  • Modified Polynucleotides For The Production Of Cosmetic Proteins And Peptides
  • Generation Of Induced Pluripotent Stem (Ips) Cells
  • Pluripotent Stem Cell-Derived 3d Retinal Tissue And Uses Thereof
  • Modified Polynucleotides Encoding Siah E3 Ubiquitin Protein Ligase 1
  • Dlin-Kc2-Dma Lipid Nanoparticle Delivery Of Modified Polynucleotides
  • Methods For The Production Of Ips Cells
  • Programming And Reprogramming Of Cells
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Culture Method Of Embryoid Bodies And/Or Neural Stem Cells Derived From Human Differentiated Cell-Derived Pluripotent Stem Cells
  • Isolated Naive Pluripotent Stem Cells And Methods Of Generating Same
  • Method For Producing Induced Pluripotent Stem Cells, Cardiomyocytes Or Precursor Cells Thereof
  • Culture Method Of Embryoid Bodies And/Or Neural Stem Cells Derived From Human Differentiated Cell-Derived Pluripotent Stem Cells
  • Reprogramming Somatic Cells Using Retroviral Vectors Comprising Oct-4 And Sox2 Genes
  • Stem Cells And Uses Thereof
  • Low-Molecular-Compound For Improving Production, Maintenance And Proliferation Of Pluripotent Stem Cells, Composition Comprising The Same, And Culture Method
  • Preparation Of Retinal Pigment Epithelium Cells
  • Modified Polynucleotides Encoding Hepatitis A Virus Cellular Receptor 2
  • Materials And Methods For Generating Pluripotent Stem Cells
  • In Vivo Production Of Proteins
  • Method For Rejuvenating Cells
  • Oct3/4, Klf4, C-Myc And Sox2 Produce Induced Pluripotent Stem Cells
  • Methods Of Treating Diseases Related To Mitochondrial Function
  • Multipotent Stem Cell Cultures
  • Modified Polynucleotides For The Production Of Proteins
  • Reprogrammation Of Eukaryotic Cells With Engineered Microvesicles
  • Method For Producing A Protein Of Interest In A Primate
  • Method For Preparing Induced Paraxial Mesoderm Progenitor (Ipam) Cells And Their Use
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Large Scale Generation Of Functional Megakaryocytes And Platelets From Human Embryonic Stem Cells Under Stromal-Free Conditions
  • Cell Compositions Derived From Dedifferentiated Reprogrammed Cells
  • Cell Compositions Derived From Dedifferentiated Reprogrammed Cells
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Epigenomic Induced Pluripotent Stem Cell Signatures
  • Human Pluripotent Stem Cells Induced From Undifferentiated Stem Cells Derived From A Human Postnatal Tissue
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Modified Polynucleotides Encoding Aquaporin-5
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Ets2 And Mesp1 Generate Cardiac Progenitors From Fibroblasts
  • Human Pluripotent Stem Cells Induced From Undifferentiated Stem Cells Derived From A Human Postnatal Tissue
  • Populations Of Hematopoietic Progenitors And Methods Of Enriching Stem Cells Therefor
  • Differentially Methylated Regions Of Reprogrammed Induced Pluripotent Stem Cells, Method And Compositions Thereof
  • Modified Polynucleotides Encoding Aryl Hydrocarbon Receptor Nuclear Translocator
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Method For Inducing Pluripotency In Human Somatic Cells With Prdm14 Or Nfrkb
  • An Automated System For The Cultivation And Differentiation Pluripotent Stem Cells
  • Functionalized Nanoparticles For Intracellular Delivery Of Biologically Active Molecules
  • Pluripotent Cell Lines And Methods Of Use Thereof
  • Split Dose Administration
  • Method Of Effecting De-Differentiation Of A Cell
  • Method Of Efficiently Establishing Induced Pluripotent Stem Cells
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Formulation And Delivery Of Plga Microspheres
  • Autologous Mammalian Models Derived From Induced Pluripotent Stem Cells And Related Methods
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature06534

    DOI

    http://dx.doi.org/10.1038/nature06534

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011992920

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18157115


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Shape", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA-Binding Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Embryonic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fetus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroblasts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HMGB Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Homeodomain Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant, Newborn", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kruppel-Like Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nanog Homeobox Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Octamer Transcription Factor-3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pluripotent Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Promoter Regions, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-myc", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "SOXB1 Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Teratoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation, Heterologous", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "In-Hyun", 
            "id": "sg:person.0633264666.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633264666.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Rui", 
            "id": "sg:person.0701400066.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701400066.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "West", 
            "givenName": "Jason A.", 
            "id": "sg:person.01300040514.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300040514.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yabuuchi", 
            "givenName": "Akiko", 
            "id": "sg:person.01165236266.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165236266.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huo", 
            "givenName": "Hongguang", 
            "id": "sg:person.01206166374.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206166374.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pathology, Brigham and Women\u2019s Hospital, and,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ince", 
            "givenName": "Tan A.", 
            "id": "sg:person.01233401714.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233401714.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Boston Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "Division of Newborn Medicine, Brigham & Women\u2019s Hospital and Children\u2019s Hospital Boston, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lerou", 
            "givenName": "Paul H.", 
            "id": "sg:person.01071737774.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071737774.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lensch", 
            "givenName": "M. William", 
            "id": "sg:person.01022207136.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022207136.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Daley", 
            "givenName": "George Q.", 
            "id": "sg:person.01326207001.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326207001.66"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature05934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002347899", 
              "https://doi.org/10.1038/nature05934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1107-1211a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003688019", 
              "https://doi.org/10.1038/nbt1107-1211a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c400479200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007614091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.07.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010757497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010904856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011219533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013128911", 
              "https://doi.org/10.1038/nbt788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013128911", 
              "https://doi.org/10.1038/nbt788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014573758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1059399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017152833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e07-01-0029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018776426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019109862", 
              "https://doi.org/10.1038/nature05944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/22780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021312708", 
              "https://doi.org/10.1038/22780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/22780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021312708", 
              "https://doi.org/10.1038/22780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024217468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024578139", 
              "https://doi.org/10.1038/nbt1310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.21.22.7653-7662.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025491284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029649252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80103-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030923499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000035254.80718.91", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032098280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1116447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032194044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033397919", 
              "https://doi.org/10.1038/nbt1318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(01)00459-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037472156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049953935", 
              "https://doi.org/10.1038/nbt1335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.279.5349.349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051728512"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2008-01", 
        "datePublishedReg": "2008-01-01", 
        "description": "Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the organism. Embryonic stem cells are embryo-derived cell lines that retain pluripotency and represent invaluable tools for research into the mechanisms of tissue formation. Recently, murine fibroblasts have been reprogrammed directly to pluripotency by ectopic expression of four transcription factors (Oct4, Sox2, Klf4 and Myc) to yield induced pluripotent stem (iPS) cells. Using these same factors, we have derived iPS cells from fetal, neonatal and adult human primary cells, including dermal fibroblasts isolated from a skin biopsy of a healthy research subject. Human iPS cells resemble embryonic stem cells in morphology and gene expression and in the capacity to form teratomas in immune-deficient mice. These data demonstrate that defined factors can reprogramme human cells to pluripotency, and establish a method whereby patient-specific cells might be established in culture.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature06534", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7175", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "451"
          }
        ], 
        "name": "Reprogramming of human somatic cells to pluripotency with defined factors", 
        "pagination": "141", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3924206cee960335cad5c13f2442954123d51a593d3ea4cf93b168dd6eed43a3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "18157115"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature06534"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1011992920"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature06534", 
          "https://app.dimensions.ai/details/publication/pub.1011992920"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000422.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature06534"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature06534'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature06534'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature06534'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature06534'


     

    This table displays all metadata directly associated to this object as RDF triples.

    322 TRIPLES      21 PREDICATES      78 URIs      47 LITERALS      35 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature06534 schema:about N02c96369dc104150a044c11a249732c6
    2 N17c6edfbb72846cf9ed57d4bf45dbb6f
    3 N1ff9bb2f8cd64adeb187390a9ec20028
    4 N211d0c8df4b146ad84cbb0c0617628aa
    5 N23224cdcfa77413eab7a5ded422d37a3
    6 N37ab9a3609e049af9cd7039eb7745ee8
    7 N382fb1501a21497ca139a978160c8250
    8 N422b3bad387940d5ab6d3f3ed1ae71f3
    9 N6ca7968be2564ec6b6c7bcc3282f3b3e
    10 N76701bb7e9df4ea5a520d5892b627290
    11 N7d221d72dfe84215a55c330c582d78e6
    12 N7fd2552e3431491eb2465a12dafee4de
    13 N8040665d393243d182f88341ee21e61a
    14 N9ef77d8ec6264501bd52b47d541e1d4a
    15 Na1aff78336b1430cb58d10b5d91b2d6f
    16 Nbf36a3b16c56440e80f6d20c36f4189e
    17 Nc2842c04ff244230bc296aac73dfd4b7
    18 Nc5b79e0e965a4d8a8cbd84a076964449
    19 Ne0df62c9bac445c88c13a2cb3b418ea3
    20 Neacfe96b35b843ec918b041665ed9fbe
    21 Ned06a9ca628043969664b1d68be13379
    22 Nf93df6cf20874942aeba8d3ce3aec395
    23 Nfc0e2e0062164db8992ddfe884df9e63
    24 Nfce9f69dfff847bea4e63c342acb13b2
    25 Nfd1cbf0edd8e4300a4f76311b243475e
    26 Nfdf2979a3e404be7bd76934edad85e14
    27 anzsrc-for:06
    28 anzsrc-for:0604
    29 schema:author Ncb0146062f004e06ba4411d3721e8e8f
    30 schema:citation sg:pub.10.1038/22780
    31 sg:pub.10.1038/nature05934
    32 sg:pub.10.1038/nature05944
    33 sg:pub.10.1038/nbt1107-1211a
    34 sg:pub.10.1038/nbt1310
    35 sg:pub.10.1038/nbt1318
    36 sg:pub.10.1038/nbt1335
    37 sg:pub.10.1038/nbt788
    38 https://doi.org/10.1016/j.cell.2004.11.011
    39 https://doi.org/10.1016/j.cell.2006.07.024
    40 https://doi.org/10.1016/j.cell.2007.11.019
    41 https://doi.org/10.1016/j.stem.2007.05.014
    42 https://doi.org/10.1016/j.stem.2007.07.019
    43 https://doi.org/10.1016/j.stem.2007.08.008
    44 https://doi.org/10.1016/s0960-9822(01)00459-6
    45 https://doi.org/10.1016/s1074-7613(00)80103-x
    46 https://doi.org/10.1074/jbc.c400479200
    47 https://doi.org/10.1091/mbc.e07-01-0029
    48 https://doi.org/10.1126/science.1059399
    49 https://doi.org/10.1126/science.1116447
    50 https://doi.org/10.1126/science.279.5349.349
    51 https://doi.org/10.1128/mcb.21.22.7653-7662.2001
    52 https://doi.org/10.1161/01.res.0000035254.80718.91
    53 schema:datePublished 2008-01
    54 schema:datePublishedReg 2008-01-01
    55 schema:description Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the organism. Embryonic stem cells are embryo-derived cell lines that retain pluripotency and represent invaluable tools for research into the mechanisms of tissue formation. Recently, murine fibroblasts have been reprogrammed directly to pluripotency by ectopic expression of four transcription factors (Oct4, Sox2, Klf4 and Myc) to yield induced pluripotent stem (iPS) cells. Using these same factors, we have derived iPS cells from fetal, neonatal and adult human primary cells, including dermal fibroblasts isolated from a skin biopsy of a healthy research subject. Human iPS cells resemble embryonic stem cells in morphology and gene expression and in the capacity to form teratomas in immune-deficient mice. These data demonstrate that defined factors can reprogramme human cells to pluripotency, and establish a method whereby patient-specific cells might be established in culture.
    56 schema:genre research_article
    57 schema:inLanguage en
    58 schema:isAccessibleForFree false
    59 schema:isPartOf N1b5ffc0aad7f4771be81b2f9ea5e9ab4
    60 N2a351d9131244a5db9b40ff27618ebf4
    61 sg:journal.1018957
    62 schema:name Reprogramming of human somatic cells to pluripotency with defined factors
    63 schema:pagination 141
    64 schema:productId N4a6c9654e9334bec9cbf7bad8275ba18
    65 N4cb0ff2805b84e84a0d8e56695320f5d
    66 N7d53cad97e4a476e856e012977e20366
    67 Na2079d53f30e4f81bc7822a55705300d
    68 Nc7eee23d5d0e420dac5cf4ff5daf70e1
    69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011992920
    70 https://doi.org/10.1038/nature06534
    71 schema:sdDatePublished 2019-04-10T16:28
    72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    73 schema:sdPublisher Neb42b49942ec4328aea8d846ac86fae0
    74 schema:url https://www.nature.com/articles/nature06534
    75 sgo:license sg:explorer/license/
    76 sgo:sdDataset articles
    77 rdf:type schema:ScholarlyArticle
    78 N02c96369dc104150a044c11a249732c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    79 schema:name Octamer Transcription Factor-3
    80 rdf:type schema:DefinedTerm
    81 N0533d09d173f47d5a531e575c24b29e3 schema:name Division of Pediatric Hematology/Oncology, Children’s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    82 rdf:type schema:Organization
    83 N0c862d5c41b34619a95ed5834a464d0f schema:name Division of Pediatric Hematology/Oncology, Children’s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    84 rdf:type schema:Organization
    85 N17c6edfbb72846cf9ed57d4bf45dbb6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Homeodomain Proteins
    87 rdf:type schema:DefinedTerm
    88 N19215bffb03e4d61bbbc6df67268f1b8 rdf:first sg:person.01206166374.49
    89 rdf:rest Nac5cf3956c684afbb6ee9977f0d1b84d
    90 N1b5ffc0aad7f4771be81b2f9ea5e9ab4 schema:issueNumber 7175
    91 rdf:type schema:PublicationIssue
    92 N1f38b2392b8149a5b8d63d3870f58c88 schema:name Division of Pediatric Hematology/Oncology, Children’s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    93 rdf:type schema:Organization
    94 N1ff9bb2f8cd64adeb187390a9ec20028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Animals
    96 rdf:type schema:DefinedTerm
    97 N211d0c8df4b146ad84cbb0c0617628aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Embryonic Stem Cells
    99 rdf:type schema:DefinedTerm
    100 N23224cdcfa77413eab7a5ded422d37a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name DNA-Binding Proteins
    102 rdf:type schema:DefinedTerm
    103 N2a351d9131244a5db9b40ff27618ebf4 schema:volumeNumber 451
    104 rdf:type schema:PublicationVolume
    105 N3617f08e14c042f38e9badac3ae9fae7 schema:name Division of Pediatric Hematology/Oncology, Children’s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    106 rdf:type schema:Organization
    107 N37ab9a3609e049af9cd7039eb7745ee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name DNA Methylation
    109 rdf:type schema:DefinedTerm
    110 N382fb1501a21497ca139a978160c8250 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Cells, Cultured
    112 rdf:type schema:DefinedTerm
    113 N422b3bad387940d5ab6d3f3ed1ae71f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Infant, Newborn
    115 rdf:type schema:DefinedTerm
    116 N4a6c9654e9334bec9cbf7bad8275ba18 schema:name doi
    117 schema:value 10.1038/nature06534
    118 rdf:type schema:PropertyValue
    119 N4cb0ff2805b84e84a0d8e56695320f5d schema:name nlm_unique_id
    120 schema:value 0410462
    121 rdf:type schema:PropertyValue
    122 N4d028fb133704394a882f692437a2e8b rdf:first sg:person.01022207136.99
    123 rdf:rest N5e161d26614f42729057627dc29ab1c9
    124 N547ec7232d274f6194cfd1ed2e02eb75 schema:name Division of Pediatric Hematology/Oncology, Children’s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    125 rdf:type schema:Organization
    126 N55a462fc5c624b2ca0627e973ce8b4af schema:name Division of Pediatric Hematology/Oncology, Children’s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    127 rdf:type schema:Organization
    128 N5e161d26614f42729057627dc29ab1c9 rdf:first sg:person.01326207001.66
    129 rdf:rest rdf:nil
    130 N644ba9b8ff7e48d9b7cf074ee23d8ca4 schema:name Division of Pediatric Hematology/Oncology, Children’s Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA; and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    131 rdf:type schema:Organization
    132 N6ca7968be2564ec6b6c7bcc3282f3b3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Fetus
    134 rdf:type schema:DefinedTerm
    135 N6d5c9aa48bf34678a09a0e281b3b1bec schema:name Department of Pathology, Brigham and Women’s Hospital, and,
    136 rdf:type schema:Organization
    137 N76701bb7e9df4ea5a520d5892b627290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Kruppel-Like Transcription Factors
    139 rdf:type schema:DefinedTerm
    140 N7d221d72dfe84215a55c330c582d78e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Nanog Homeobox Protein
    142 rdf:type schema:DefinedTerm
    143 N7d53cad97e4a476e856e012977e20366 schema:name dimensions_id
    144 schema:value pub.1011992920
    145 rdf:type schema:PropertyValue
    146 N7fd2552e3431491eb2465a12dafee4de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Promoter Regions, Genetic
    148 rdf:type schema:DefinedTerm
    149 N8040665d393243d182f88341ee21e61a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Fibroblasts
    151 rdf:type schema:DefinedTerm
    152 N912727d2c5e6453eb9458c5bc140dba3 rdf:first sg:person.01165236266.47
    153 rdf:rest N19215bffb03e4d61bbbc6df67268f1b8
    154 N9ef77d8ec6264501bd52b47d541e1d4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Cell Differentiation
    156 rdf:type schema:DefinedTerm
    157 Na1aff78336b1430cb58d10b5d91b2d6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Pluripotent Stem Cells
    159 rdf:type schema:DefinedTerm
    160 Na2079d53f30e4f81bc7822a55705300d schema:name readcube_id
    161 schema:value 3924206cee960335cad5c13f2442954123d51a593d3ea4cf93b168dd6eed43a3
    162 rdf:type schema:PropertyValue
    163 Nac5cf3956c684afbb6ee9977f0d1b84d rdf:first sg:person.01233401714.29
    164 rdf:rest Nb4efbb944f5c4724a7b3c2494021bb5b
    165 Nb4efbb944f5c4724a7b3c2494021bb5b rdf:first sg:person.01071737774.79
    166 rdf:rest N4d028fb133704394a882f692437a2e8b
    167 Nbf36a3b16c56440e80f6d20c36f4189e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Transcription Factors
    169 rdf:type schema:DefinedTerm
    170 Nbfce80a26d794b6e8d4cfd6ea7500195 rdf:first sg:person.01300040514.16
    171 rdf:rest N912727d2c5e6453eb9458c5bc140dba3
    172 Nc2842c04ff244230bc296aac73dfd4b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Proto-Oncogene Proteins c-myc
    174 rdf:type schema:DefinedTerm
    175 Nc5b79e0e965a4d8a8cbd84a076964449 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Humans
    177 rdf:type schema:DefinedTerm
    178 Nc7eee23d5d0e420dac5cf4ff5daf70e1 schema:name pubmed_id
    179 schema:value 18157115
    180 rdf:type schema:PropertyValue
    181 Ncb0146062f004e06ba4411d3721e8e8f rdf:first sg:person.0633264666.40
    182 rdf:rest Ndb94736cdda54659901aa44af311c785
    183 Ndb94736cdda54659901aa44af311c785 rdf:first sg:person.0701400066.39
    184 rdf:rest Nbfce80a26d794b6e8d4cfd6ea7500195
    185 Ne0df62c9bac445c88c13a2cb3b418ea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Gene Expression Profiling
    187 rdf:type schema:DefinedTerm
    188 Neacfe96b35b843ec918b041665ed9fbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Teratoma
    190 rdf:type schema:DefinedTerm
    191 Neb42b49942ec4328aea8d846ac86fae0 schema:name Springer Nature - SN SciGraph project
    192 rdf:type schema:Organization
    193 Ned06a9ca628043969664b1d68be13379 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Cell Shape
    195 rdf:type schema:DefinedTerm
    196 Nf93df6cf20874942aeba8d3ce3aec395 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Adult
    198 rdf:type schema:DefinedTerm
    199 Nfc0e2e0062164db8992ddfe884df9e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Mice
    201 rdf:type schema:DefinedTerm
    202 Nfce9f69dfff847bea4e63c342acb13b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name HMGB Proteins
    204 rdf:type schema:DefinedTerm
    205 Nfd1cbf0edd8e4300a4f76311b243475e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name SOXB1 Transcription Factors
    207 rdf:type schema:DefinedTerm
    208 Nfdf2979a3e404be7bd76934edad85e14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Transplantation, Heterologous
    210 rdf:type schema:DefinedTerm
    211 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Biological Sciences
    213 rdf:type schema:DefinedTerm
    214 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Genetics
    216 rdf:type schema:DefinedTerm
    217 sg:journal.1018957 schema:issn 0090-0028
    218 1476-4687
    219 schema:name Nature
    220 rdf:type schema:Periodical
    221 sg:person.01022207136.99 schema:affiliation N1f38b2392b8149a5b8d63d3870f58c88
    222 schema:familyName Lensch
    223 schema:givenName M. William
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022207136.99
    225 rdf:type schema:Person
    226 sg:person.01071737774.79 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
    227 schema:familyName Lerou
    228 schema:givenName Paul H.
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071737774.79
    230 rdf:type schema:Person
    231 sg:person.01165236266.47 schema:affiliation N3617f08e14c042f38e9badac3ae9fae7
    232 schema:familyName Yabuuchi
    233 schema:givenName Akiko
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165236266.47
    235 rdf:type schema:Person
    236 sg:person.01206166374.49 schema:affiliation N0c862d5c41b34619a95ed5834a464d0f
    237 schema:familyName Huo
    238 schema:givenName Hongguang
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206166374.49
    240 rdf:type schema:Person
    241 sg:person.01233401714.29 schema:affiliation N6d5c9aa48bf34678a09a0e281b3b1bec
    242 schema:familyName Ince
    243 schema:givenName Tan A.
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233401714.29
    245 rdf:type schema:Person
    246 sg:person.01300040514.16 schema:affiliation N55a462fc5c624b2ca0627e973ce8b4af
    247 schema:familyName West
    248 schema:givenName Jason A.
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300040514.16
    250 rdf:type schema:Person
    251 sg:person.01326207001.66 schema:affiliation N644ba9b8ff7e48d9b7cf074ee23d8ca4
    252 schema:familyName Daley
    253 schema:givenName George Q.
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326207001.66
    255 rdf:type schema:Person
    256 sg:person.0633264666.40 schema:affiliation N547ec7232d274f6194cfd1ed2e02eb75
    257 schema:familyName Park
    258 schema:givenName In-Hyun
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633264666.40
    260 rdf:type schema:Person
    261 sg:person.0701400066.39 schema:affiliation N0533d09d173f47d5a531e575c24b29e3
    262 schema:familyName Zhao
    263 schema:givenName Rui
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701400066.39
    265 rdf:type schema:Person
    266 sg:pub.10.1038/22780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021312708
    267 https://doi.org/10.1038/22780
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nature05934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002347899
    270 https://doi.org/10.1038/nature05934
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nature05944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019109862
    273 https://doi.org/10.1038/nature05944
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nbt1107-1211a schema:sameAs https://app.dimensions.ai/details/publication/pub.1003688019
    276 https://doi.org/10.1038/nbt1107-1211a
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nbt1310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024578139
    279 https://doi.org/10.1038/nbt1310
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nbt1318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033397919
    282 https://doi.org/10.1038/nbt1318
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nbt1335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049953935
    285 https://doi.org/10.1038/nbt1335
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nbt788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013128911
    288 https://doi.org/10.1038/nbt788
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.cell.2004.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024217468
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.cell.2006.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014573758
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.stem.2007.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029649252
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.stem.2007.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010757497
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.stem.2007.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011219533
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/s0960-9822(01)00459-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037472156
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/s1074-7613(00)80103-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030923499
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1074/jbc.c400479200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007614091
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1091/mbc.e07-01-0029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018776426
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1126/science.1059399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017152833
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1126/science.1116447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032194044
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1126/science.279.5349.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051728512
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1128/mcb.21.22.7653-7662.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025491284
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1161/01.res.0000035254.80718.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032098280
    319 rdf:type schema:CreativeWork
    320 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
    321 schema:name Division of Newborn Medicine, Brigham & Women’s Hospital and Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    322 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...