The X-ray crystal structure of RNA polymerase from Archaea View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02

AUTHORS

Akira Hirata, Brianna J. Klein, Katsuhiko S. Murakami

ABSTRACT

The transcription apparatus in Archaea can be described as a simplified version of its eukaryotic RNA polymerase (RNAP) II counterpart, comprising an RNAPII-like enzyme as well as two general transcription factors, the TATA-binding protein (TBP) and the eukaryotic TFIIB orthologue TFB. It has been widely understood that precise comparisons of cellular RNAP crystal structures could reveal structural elements common to all enzymes and that these insights would be useful in analysing components of each enzyme that enable it to perform domain-specific gene expression. However, the structure of archaeal RNAP has been limited to individual subunits. Here we report the first crystal structure of the archaeal RNAP from Sulfolobus solfataricus at 3.4 A resolution, completing the suite of multi-subunit RNAP structures from all three domains of life. We also report the high-resolution (at 1.76 A) crystal structure of the D/L subcomplex of archaeal RNAP and provide the first experimental evidence of any RNAP possessing an iron-sulphur (Fe-S) cluster, which may play a structural role in a key subunit of RNAP assembly. The striking structural similarity between archaeal RNAP and eukaryotic RNAPII highlights the simpler archaeal RNAP as an ideal model system for dissecting the molecular basis of eukaryotic transcription. More... »

PAGES

851

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature06530

DOI

http://dx.doi.org/10.1038/nature06530

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016216700

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18235446


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Directed RNA Polymerases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Iron-Sulfur Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Folding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Subunits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfolobus solfataricus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taq Polymerase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pennsylvania State University", 
          "id": "https://www.grid.ac/institutes/grid.29857.31", 
          "name": [
            "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirata", 
        "givenName": "Akira", 
        "id": "sg:person.0734102130.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734102130.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pennsylvania State University", 
          "id": "https://www.grid.ac/institutes/grid.29857.31", 
          "name": [
            "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klein", 
        "givenName": "Brianna J.", 
        "id": "sg:person.01077711010.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077711010.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pennsylvania State University", 
          "id": "https://www.grid.ac/institutes/grid.29857.31", 
          "name": [
            "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murakami", 
        "givenName": "Katsuhiko S.", 
        "id": "sg:person.01023761331.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023761331.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1126/science.1131399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001559852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.21.11274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003162337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1090838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004847683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.02.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004967664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00629-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009300474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c400446200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011364433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.18.8344-8355.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011596288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.11.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012304974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.12.6311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014929775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1059493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015760622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1069594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017722678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00286-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018107249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1030608100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019574256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998003254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m413038200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020609552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(90)90199-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021158271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(90)90199-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021158271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1130601100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023101111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2005.04627.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023392948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2005.04627.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023392948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m611674200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024013779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81515-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027561936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444900014736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033401324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(98)01203-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034905419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0966-842x(98)01281-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036222197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2005.07.073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038837461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444900005072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038886912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m605209200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043986461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444905001617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044610818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048079849", 
          "https://doi.org/10.1038/nature05931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2000.4309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048150098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048265810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10409230600648736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050133927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00379-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050585236"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-02", 
    "datePublishedReg": "2008-02-01", 
    "description": "The transcription apparatus in Archaea can be described as a simplified version of its eukaryotic RNA polymerase (RNAP) II counterpart, comprising an RNAPII-like enzyme as well as two general transcription factors, the TATA-binding protein (TBP) and the eukaryotic TFIIB orthologue TFB. It has been widely understood that precise comparisons of cellular RNAP crystal structures could reveal structural elements common to all enzymes and that these insights would be useful in analysing components of each enzyme that enable it to perform domain-specific gene expression. However, the structure of archaeal RNAP has been limited to individual subunits. Here we report the first crystal structure of the archaeal RNAP from Sulfolobus solfataricus at 3.4 A resolution, completing the suite of multi-subunit RNAP structures from all three domains of life. We also report the high-resolution (at 1.76 A) crystal structure of the D/L subcomplex of archaeal RNAP and provide the first experimental evidence of any RNAP possessing an iron-sulphur (Fe-S) cluster, which may play a structural role in a key subunit of RNAP assembly. The striking structural similarity between archaeal RNAP and eukaryotic RNAPII highlights the simpler archaeal RNAP as an ideal model system for dissecting the molecular basis of eukaryotic transcription.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature06530", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2518513", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7180", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "451"
      }
    ], 
    "name": "The X-ray crystal structure of RNA polymerase from Archaea", 
    "pagination": "851", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4d44ca1c26580fcb9d0f24b2330ff99a2978d00e87e83737f381f2b2b78d0634"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18235446"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature06530"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016216700"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature06530", 
      "https://app.dimensions.ai/details/publication/pub.1016216700"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature06530"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature06530'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature06530'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature06530'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature06530'


 

This table displays all metadata directly associated to this object as RDF triples.

222 TRIPLES      21 PREDICATES      71 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature06530 schema:about N0588be27b12b4e5c8b0e7f17564dfead
2 N0cf4c4cd8d6445eba77cd49006b0833d
3 N1ce2fa4339f749ef98d30a3d163b9066
4 N44b2dbf825ae4b9b995d728e74c7a447
5 N49996471c53543329550b8fa18602876
6 Ne6d0c0a1fcb8429eb8c14137af9233bd
7 Ne73b5ebc3af54b4c9b3626ea15979ebb
8 Nec269ff651bf479ab765e471df8ace6b
9 Nf3059b501c1e433a95e1e77219225736
10 Nf9d37c25294f4775b3b05315a76e7cfb
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N200ca59261544a8cbe4adc964c12ca10
14 schema:citation sg:pub.10.1038/nature05931
15 https://doi.org/10.1006/jmbi.2000.4309
16 https://doi.org/10.1016/0378-1119(90)90199-2
17 https://doi.org/10.1016/j.cell.2004.10.016
18 https://doi.org/10.1016/j.cell.2006.11.023
19 https://doi.org/10.1016/j.jmb.2005.07.073
20 https://doi.org/10.1016/j.molcel.2007.02.016
21 https://doi.org/10.1016/s0092-8674(00)81515-9
22 https://doi.org/10.1016/s0092-8674(01)00286-0
23 https://doi.org/10.1016/s0966-842x(98)01281-5
24 https://doi.org/10.1016/s0968-0004(98)01203-1
25 https://doi.org/10.1016/s1097-2765(01)00379-3
26 https://doi.org/10.1016/s1097-2765(02)00629-9
27 https://doi.org/10.1073/pnas.1030608100
28 https://doi.org/10.1073/pnas.1130601100
29 https://doi.org/10.1073/pnas.94.21.11274
30 https://doi.org/10.1073/pnas.97.12.6311
31 https://doi.org/10.1074/jbc.c400446200
32 https://doi.org/10.1074/jbc.m413038200
33 https://doi.org/10.1074/jbc.m605209200
34 https://doi.org/10.1074/jbc.m611674200
35 https://doi.org/10.1080/10409230600648736
36 https://doi.org/10.1107/s0907444900005072
37 https://doi.org/10.1107/s0907444900014736
38 https://doi.org/10.1107/s0907444905001617
39 https://doi.org/10.1107/s0907444998003254
40 https://doi.org/10.1111/j.1365-2958.2005.04627.x
41 https://doi.org/10.1126/science.1059493
42 https://doi.org/10.1126/science.1069594
43 https://doi.org/10.1126/science.1090838
44 https://doi.org/10.1126/science.1131399
45 https://doi.org/10.1128/mcb.25.18.8344-8355.2005
46 schema:datePublished 2008-02
47 schema:datePublishedReg 2008-02-01
48 schema:description The transcription apparatus in Archaea can be described as a simplified version of its eukaryotic RNA polymerase (RNAP) II counterpart, comprising an RNAPII-like enzyme as well as two general transcription factors, the TATA-binding protein (TBP) and the eukaryotic TFIIB orthologue TFB. It has been widely understood that precise comparisons of cellular RNAP crystal structures could reveal structural elements common to all enzymes and that these insights would be useful in analysing components of each enzyme that enable it to perform domain-specific gene expression. However, the structure of archaeal RNAP has been limited to individual subunits. Here we report the first crystal structure of the archaeal RNAP from Sulfolobus solfataricus at 3.4 A resolution, completing the suite of multi-subunit RNAP structures from all three domains of life. We also report the high-resolution (at 1.76 A) crystal structure of the D/L subcomplex of archaeal RNAP and provide the first experimental evidence of any RNAP possessing an iron-sulphur (Fe-S) cluster, which may play a structural role in a key subunit of RNAP assembly. The striking structural similarity between archaeal RNAP and eukaryotic RNAPII highlights the simpler archaeal RNAP as an ideal model system for dissecting the molecular basis of eukaryotic transcription.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N7d677034c9e440118c1891105c42e96a
53 Ndabe9a507e41423f837e437fe024fd95
54 sg:journal.1018957
55 schema:name The X-ray crystal structure of RNA polymerase from Archaea
56 schema:pagination 851
57 schema:productId N05a55761cad24bb88f4293d179c04945
58 N2dbeda63668d47c5b174396a76189f5a
59 N5fe31558c74e4c468cd23be58ee7e122
60 N82122b834b9c49b98cb559dca6d3d53e
61 Ncce15c823a2e4432bf6f7e6e42ce091f
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016216700
63 https://doi.org/10.1038/nature06530
64 schema:sdDatePublished 2019-04-11T00:03
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N9b816f32ec23489bbe76f3367897d617
67 schema:url https://www.nature.com/articles/nature06530
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N0588be27b12b4e5c8b0e7f17564dfead schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Protein Subunits
73 rdf:type schema:DefinedTerm
74 N05a55761cad24bb88f4293d179c04945 schema:name doi
75 schema:value 10.1038/nature06530
76 rdf:type schema:PropertyValue
77 N07be49b6a23b449ea0e1a5abe82f3e91 rdf:first sg:person.01077711010.28
78 rdf:rest N590b4c1217ac44c89e5edef579933fa4
79 N0cf4c4cd8d6445eba77cd49006b0833d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Taq Polymerase
81 rdf:type schema:DefinedTerm
82 N1ce2fa4339f749ef98d30a3d163b9066 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Sulfolobus solfataricus
84 rdf:type schema:DefinedTerm
85 N200ca59261544a8cbe4adc964c12ca10 rdf:first sg:person.0734102130.75
86 rdf:rest N07be49b6a23b449ea0e1a5abe82f3e91
87 N2dbeda63668d47c5b174396a76189f5a schema:name dimensions_id
88 schema:value pub.1016216700
89 rdf:type schema:PropertyValue
90 N44b2dbf825ae4b9b995d728e74c7a447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Iron-Sulfur Proteins
92 rdf:type schema:DefinedTerm
93 N49996471c53543329550b8fa18602876 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Saccharomyces cerevisiae
95 rdf:type schema:DefinedTerm
96 N590b4c1217ac44c89e5edef579933fa4 rdf:first sg:person.01023761331.66
97 rdf:rest rdf:nil
98 N5fe31558c74e4c468cd23be58ee7e122 schema:name readcube_id
99 schema:value 4d44ca1c26580fcb9d0f24b2330ff99a2978d00e87e83737f381f2b2b78d0634
100 rdf:type schema:PropertyValue
101 N7d677034c9e440118c1891105c42e96a schema:volumeNumber 451
102 rdf:type schema:PublicationVolume
103 N82122b834b9c49b98cb559dca6d3d53e schema:name nlm_unique_id
104 schema:value 0410462
105 rdf:type schema:PropertyValue
106 N9b816f32ec23489bbe76f3367897d617 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 Ncce15c823a2e4432bf6f7e6e42ce091f schema:name pubmed_id
109 schema:value 18235446
110 rdf:type schema:PropertyValue
111 Ndabe9a507e41423f837e437fe024fd95 schema:issueNumber 7180
112 rdf:type schema:PublicationIssue
113 Ne6d0c0a1fcb8429eb8c14137af9233bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name DNA-Directed RNA Polymerases
115 rdf:type schema:DefinedTerm
116 Ne73b5ebc3af54b4c9b3626ea15979ebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Models, Molecular
118 rdf:type schema:DefinedTerm
119 Nec269ff651bf479ab765e471df8ace6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Crystallography, X-Ray
121 rdf:type schema:DefinedTerm
122 Nf3059b501c1e433a95e1e77219225736 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Protein Structure, Tertiary
124 rdf:type schema:DefinedTerm
125 Nf9d37c25294f4775b3b05315a76e7cfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Protein Folding
127 rdf:type schema:DefinedTerm
128 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
129 schema:name Biological Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
132 schema:name Biochemistry and Cell Biology
133 rdf:type schema:DefinedTerm
134 sg:grant.2518513 http://pending.schema.org/fundedItem sg:pub.10.1038/nature06530
135 rdf:type schema:MonetaryGrant
136 sg:journal.1018957 schema:issn 0090-0028
137 1476-4687
138 schema:name Nature
139 rdf:type schema:Periodical
140 sg:person.01023761331.66 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
141 schema:familyName Murakami
142 schema:givenName Katsuhiko S.
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023761331.66
144 rdf:type schema:Person
145 sg:person.01077711010.28 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
146 schema:familyName Klein
147 schema:givenName Brianna J.
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077711010.28
149 rdf:type schema:Person
150 sg:person.0734102130.75 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
151 schema:familyName Hirata
152 schema:givenName Akira
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734102130.75
154 rdf:type schema:Person
155 sg:pub.10.1038/nature05931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048079849
156 https://doi.org/10.1038/nature05931
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1006/jmbi.2000.4309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048150098
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/0378-1119(90)90199-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021158271
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.cell.2004.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048265810
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.cell.2006.11.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012304974
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.jmb.2005.07.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038837461
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.molcel.2007.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004967664
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/s0092-8674(00)81515-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027561936
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/s0092-8674(01)00286-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018107249
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/s0966-842x(98)01281-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036222197
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/s0968-0004(98)01203-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034905419
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/s1097-2765(01)00379-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050585236
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/s1097-2765(02)00629-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009300474
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1073/pnas.1030608100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019574256
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1073/pnas.1130601100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023101111
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1073/pnas.94.21.11274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003162337
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1073/pnas.97.12.6311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014929775
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1074/jbc.c400446200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011364433
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1074/jbc.m413038200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020609552
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1074/jbc.m605209200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043986461
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1074/jbc.m611674200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024013779
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1080/10409230600648736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050133927
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1107/s0907444900005072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038886912
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1107/s0907444900014736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033401324
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1107/s0907444905001617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044610818
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/j.1365-2958.2005.04627.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023392948
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1126/science.1059493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015760622
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1126/science.1069594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017722678
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1126/science.1090838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004847683
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1126/science.1131399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001559852
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1128/mcb.25.18.8344-8355.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011596288
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.29857.31 schema:alternateName Pennsylvania State University
221 schema:name Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
222 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...