Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-01

AUTHORS

Masahito Yamagata, Joshua R. Sanes

ABSTRACT

Making connectionsDowns syndrome cell adhesion molecules (Dscams) are adhesion molecules of the immunoglolulin superfamily. Drosophila Dscams have been implicated in the organization of neural connectivity, but little is known about the functions of the closely related molecules in vertebrates. Masahito Yamagata and Joshua Sanes now demonstrate a role for Dscam and DscamL in patterning of lamina-specific connections in the chick retina. Two other adhesion molecules, called Sidekick-1 and Sidekick-2, act in a similar way. These molecules are widely distributed in the nervous system and may be part of an 'adhesive code' that patterns neural connections in the brain. Further evidence for the importance of Dscams in vertebrate neural patterning comes from Fuerst et al., who identify a role for DSCAM in establishing neural circuits in the retina of mice. More... »

PAGES

465-469

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature06469

DOI

http://dx.doi.org/10.1038/nature06469

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049991249

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18216854


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