Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Roberto Lande, Josh Gregorio, Valeria Facchinetti, Bithi Chatterjee, Yi-Hong Wang, Bernhard Homey, Wei Cao, Yui-Hsi Wang, Bing Su, Frank O. Nestle, Tomasz Zal, Ira Mellman, Jens-Michael Schröder, Yong-Jun Liu, Michel Gilliet

ABSTRACT

Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrobial peptide LL37 (also known as CAMP) as the key factor that mediates pDC activation in psoriasis, a common autoimmune disease of the skin. LL37 converts inert self-DNA into a potent trigger of interferon production by binding the DNA to form aggregated and condensed structures that are delivered to and retained within early endocytic compartments in pDCs to trigger Toll-like receptor 9. Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis. More... »

PAGES

564

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature06116

DOI

http://dx.doi.org/10.1038/nature06116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040729438

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17873860


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