Cdk1 is sufficient to drive the mammalian cell cycle View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-08

AUTHORS

David Santamaría, Cédric Barrière, Antonio Cerqueira, Sarah Hunt, Claudine Tardy, Kathryn Newton, Javier F. Cáceres, Pierre Dubus, Marcos Malumbres, Mariano Barbacid

ABSTRACT

Mouse lacking all interphase Cdks (Cdk2, Cdk3, Cdk4 and Cdk6) undergo organogenesis and develop to midgestation, and individual cells lacking all 3 kinases are able to proliferate. However, Cdk1 is shown to be absolutely essential for cell division during the first stages of embryonic development.

PAGES

811-815

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature06046

DOI

http://dx.doi.org/10.1038/nature06046

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037045843

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17700700


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