Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-08-02

AUTHORS

Scott A. Tomlins, Bharathi Laxman, Saravana M. Dhanasekaran, Beth E. Helgeson, Xuhong Cao, David S. Morris, Anjana Menon, Xiaojun Jing, Qi Cao, Bo Han, Jindan Yu, Lei Wang, James E. Montie, Mark A. Rubin, Kenneth J. Pienta, Diane Roulston, Rajal B. Shah, Sooryanarayana Varambally, Rohit Mehra, Arul M. Chinnaiyan

ABSTRACT

Distinct translocation mechanisms and additional translocation partners for ETS genes are found in prostate cancer. This study also provides the first functional evidence that ETS gene deregulation can promote cancer cell invasion in cell lines and pre-malignant prostate lesions in a transgenic mouse model.

PAGES

595-599

Journal

TITLE

Nature

ISSUE

7153

VOLUME

448

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature06024

    DOI

    http://dx.doi.org/10.1038/nature06024

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027447235

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17671502


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