Variants conferring risk of atrial fibrillation on chromosome 4q25 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07-01

AUTHORS

Daniel F. Gudbjartsson, David O. Arnar, Anna Helgadottir, Solveig Gretarsdottir, Hilma Holm, Asgeir Sigurdsson, Adalbjorg Jonasdottir, Adam Baker, Gudmar Thorleifsson, Kristleifur Kristjansson, Arnar Palsson, Thorarinn Blondal, Patrick Sulem, Valgerdur M. Backman, Gudmundur A. Hardarson, Ebba Palsdottir, Agnar Helgason, Runa Sigurjonsdottir, Jon T. Sverrisson, Konstantinos Kostulas, Maggie C. Y. Ng, Larry Baum, Wing Yee So, Ka Sing Wong, Juliana C. N. Chan, Karen L. Furie, Steven M. Greenberg, Michelle Sale, Peter Kelly, Calum A. MacRae, Eric E. Smith, Jonathan Rosand, Jan Hillert, Ronald C. W. Ma, Patrick T. Ellinor, Gudmundur Thorgeirsson, Jeffrey R. Gulcher, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson

ABSTRACT

Take heartA genome-wide association scan in populations from Sweden, North America and China has identified two single-letter sequence variants on chromosome 4q25 as risk factors for atrial fibrillation, the most common form of cardiac arrhythmia. Both are adjacent to the PITX2 gene, known to be involved in early heart development. This work identifies PITX2 as a target for diagnostic tests and possibly for therapeutic intervention. More... »

PAGES

353-357

Journal

TITLE

Nature

ISSUE

7151

VOLUME

448

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature06007

DOI

http://dx.doi.org/10.1038/nature06007

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050786599

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17603472


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