Chromatin dynamics and the preservation of genetic information View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07

AUTHORS

Jessica A Downs, Michel C Nussenzweig, André Nussenzweig

ABSTRACT

The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin - the fibres into which DNA is packaged with a proteinaceous structural polymer - has an important role in initiating, propagating and terminating this cellular response to DNA damage. More... »

PAGES

951-958

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature05980

    DOI

    http://dx.doi.org/10.1038/nature05980

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018481990

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17581578


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