Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-08

AUTHORS

Manabu Soda, Young Lim Choi, Munehiro Enomoto, Shuji Takada, Yoshihiro Yamashita, Shunpei Ishikawa, Shin-ichiro Fujiwara, Hideki Watanabe, Kentaro Kurashina, Hisashi Hatanaka, Masashi Bando, Shoji Ohno, Yuichi Ishikawa, Hiroyuki Aburatani, Toshiro Niki, Yasunori Sohara, Yukihiko Sugiyama, Hiroyuki Mano

ABSTRACT

Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in non-small-cell lung cancer (NSCLC) cells. Mouse 3T3 fibroblasts forced to express this human fusion tyrosine kinase generated transformed foci in culture and subcutaneous tumours in nude mice. The EML4-ALK fusion transcript was detected in 6.7% (5 out of 75) of NSCLC patients examined; these individuals were distinct from those harbouring mutations in the epidermal growth factor receptor gene. Our data demonstrate that a subset of NSCLC patients may express a transforming fusion kinase that is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC. More... »

PAGES

561

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

7153

VOLUME

448

Related Patents

  • Gene Defects And Mutant Alk Kinase In Human Solid Tumors
  • Methods And Compositions For Predicting Resistance To Anticancer Treatment
  • Recurrent Gene Fusions In Prostate Cancer
  • Recurrent Gene Fusions In Breast Cancer
  • Mutation Detection Probe, Mutation Detection Method, Method Of Evaluating Drug Efficacy, And Mutation Detection Kit
  • Ntrk2 Fusions
  • Method For Identification Of Oncogene, Method For Establishment Of Cell Capable Of Expressing Oncogene, And Method For Screening For Oncogene-Targeting Substance
  • Phosphorus Containing Compounds As Protein Kinase Inhibitors
  • Diamino Heterocyclic Carboxamide Compound
  • Anaplastic Lymphoma Kinase (Alk) As Oncoantigen For Lymphoma Vaccination
  • Macrocyclic Derivatives For The Treatment Of Diseases
  • Macrocyclic Compounds And Their Use As Kinase Inhibitors
  • Methods Of Using Alk Inhibitors
  • Prognostic And/Or Predictive Biomarkers And Biological Applications Thereof
  • Crystal Of Tetracyclic Compound
  • Prognostic And/Or Predictive Biomarkers And Biological Applications Thereof
  • Raf Gene Fusions
  • Eml4-Alk Fusion Gene
  • Gene Defects And Mutant Alk Kinase In Human Solid Tumors
  • Pyrimidine Compounds That Inhibit Anaplastic Lymphoma Kinase
  • Eml4-Alk Fusion Gene
  • Identification, Assessment, And Therapy Of Cancers With Innate Or Acquired Resistance To Alk Inhibitors
  • Recurrent Gene Fusions In Prostate Cancer
  • Methods Of Treating Non-Small Cell Lung Carcinoma (Nsclc)
  • Tmprss2 For The Diagnosis Of Prostate Disease
  • Raf1 Fusions
  • Anaplastic Lymphoma Kinase (Alk) As Oncoantigen For Lymphoma Vaccination
  • Gene Defects And Mutant Alk Kinase In Human Solid Tumors
  • Method For Producing Circular Dna Formed From Single-Molecule Dna
  • Mipol1-Etv1 Gene Rearrangements
  • Methods Of Treating Lung Cancer Using Inhibitors Anaplastic Lymphoma Kinase
  • Classification And Actionability Indices For Lung Cancer
  • Gene Defects And Mutant Alk Kinase In Human Solid Tumors
  • Method For Producing Circular Dna Formed From Single-Molecule Dna
  • Solid Forms Of A Macrocyclic Kinase Inhibitor
  • Recurrent Gene Fusions In Prostate Cancer
  • Fused Bicyclic 2,4-Diaminopyrimidine Derivative As A Dual Alk And Fak Inhibitor
  • Method Of Treating Cancer
  • Solid Forms Of A Macrocyclic Kinase Inhibitor
  • Phosphorus Containing Compounds As Protein Kinase Inhibitors
  • Eml4-Alk Fusion Gene
  • Di(Arylamino)Aryl Compounds
  • Picolinamide Inhibitors Of Kinases
  • Fused Bicyclic 2,4-Diaminopyrimidine Derivative As A Dual Alk And Fak Inhibitor
  • Method For Determining Effectiveness Of Cancer Treatment By Assessing The Presence Of A Kif5b-Ret Chimeric Gene
  • Method For Exclusive Selection Of Circularized Dna From Monomolecular Dna When Circularizing Dna Molecules
  • Methods Of Identifying Genomic Translocations Associated With Cancer
  • Diamino Heterocyclic Carboxamide Compound
  • Pkn1 Fusions
  • Volatile Organic Compounds For Detecting Cell Dysplasia And Genetic Alterations Associated With Lung Cancer
  • Crystalline Forms Of Lorlatinib Maleate
  • Macrocyclic Compounds As Alk, Fak And Jak2 Inhibitors
  • Fusion Polynucleotides And Fusion Polypeptides Associated With Cancer And Particularly Melanoma And Their Uses As Therapeutic And Diagnostic Targets
  • Method For Producing Circular Dna Formed From Single-Molecule Dna
  • Macrocyclic Compounds And Their Use As Kinase Inhibitors
  • Methods And Compositions For Predicting Resistance To Anticancer Treatment
  • Pyrimidine Compounds That Inhibit Anaplastic Lymphoma Kinase
  • Method For Exclusive Selection Of Circularized Dna From Monomolecular Dna In Circularizing Dna Molecules
  • Pyrrolotriazines As Alk Inhibitors
  • Prkacb Fusions
  • Phosphorylation And Mutations Of Anaplastic Lymphoma Kinase As A Diagnostic And Therapeutic Target In Lung Cancer
  • Recurrent Gene Fusions In Prostate Cancer
  • Fused Bicyclic 2,4-Diaminopyrimidine Derivative As A Dual Alk And Fak Inhibitor
  • Fish Assay For Eml4 And Alk Fusion In Lung Cancer
  • Fish Assay For Eml4 And Alk Fusion In Lung Cancer
  • Method For Identification Of Oncogene, Method For Establishment Of Cell Capable Of Expressing Oncogene, And Method For Screening For Oncogene-Targeting Substance
  • Mipol1-Etv1 Gene Rearrangements
  • Classification And Actionability Indices For Cancer
  • Method For Producing Circular Dna Formed From Single-Molecule Dna
  • Crystalline Form Of Lorlatinib Free Base
  • Composition Comprising Tetracyclic Compound
  • Identification, Assessment, And Therapy Of Cancers With Innate Or Acquired Resistance To Alk Inhibitors
  • Novel Fusion Genes In Lung Cancer
  • Eml4-Alk Fusion Gene
  • Imidazo[4,5-B]Pyridine Derivatives As Alk And Jak Modulators For The Treatment Of Proliferative Disorders
  • Compositions For Detecting Mutant Anaplastic Lymphoma Kinase In Lung Cancer
  • Recurrent Gene Fusions In Prostate Cancer
  • Eml4-Alk Fusion Gene
  • Recurrent Gene Fusions In Prostate Cancer
  • Tetracyclic Compound
  • Method For Detecting Fusion Gene
  • Benzimidazole And Azabenzimidazole Compounds That Inhibit Anaplastic Lymphoma Kinase
  • Recurrent Gene Fusions In Prostate Cancer
  • Gene Defects And Mutant Alk Kinase In Human Solid Tumors
  • Fish Assay For Eml4 And Alk Fusion In Lung Cancer
  • Methods And Compositions Relating To Fusions Of Alk For Diagnosing And Treating Cancer
  • Eml4-Alk Fusion Gene
  • Tetracyclic Compound
  • Met Fusions
  • Pik3ca Fusions
  • Methods For Detecting Gene Dysregulation By Intragenic Differential Expression
  • Gene Defects And Mutant Alk Kinase In Human Solid Tumors
  • Raf Gene Fusions
  • Methods For Detecting Gene Dysregulation By Intragenic Differential Expression
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature05945

    DOI

    http://dx.doi.org/10.1038/nature05945

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017221313

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17625570


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "3T3 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Non-Small-Cell Lung", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Inversion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, Pair 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microtubule-Associated Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oncogene Proteins, Fusion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Tyrosine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor Protein-Tyrosine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Serine Endopeptidases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,", 
                "Division of Pulmonary Medicine,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soda", 
            "givenName": "Manabu", 
            "id": "sg:person.01342673412.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342673412.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Young Lim", 
            "id": "sg:person.011253172514.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011253172514.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,", 
                "Division of Pulmonary Medicine,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Enomoto", 
            "givenName": "Munehiro", 
            "id": "sg:person.01030446374.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030446374.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takada", 
            "givenName": "Shuji", 
            "id": "sg:person.01076561574.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076561574.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamashita", 
            "givenName": "Yoshihiro", 
            "id": "sg:person.01356113147.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356113147.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishikawa", 
            "givenName": "Shunpei", 
            "id": "sg:person.013043263602.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013043263602.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujiwara", 
            "givenName": "Shin-ichiro", 
            "id": "sg:person.01073536015.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073536015.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Hideki", 
            "id": "sg:person.0646104574.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646104574.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kurashina", 
            "givenName": "Kentaro", 
            "id": "sg:person.0714217774.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714217774.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Functional Genomics,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hatanaka", 
            "givenName": "Hisashi", 
            "id": "sg:person.01046231641.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046231641.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pulmonary Medicine,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bando", 
            "givenName": "Masashi", 
            "id": "sg:person.01263547760.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263547760.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pulmonary Medicine,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohno", 
            "givenName": "Shoji", 
            "id": "sg:person.01052511041.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052511041.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishikawa", 
            "givenName": "Yuichi", 
            "id": "sg:person.01052642300.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052642300.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Japan Science and Technology Agency", 
              "id": "https://www.grid.ac/institutes/grid.419082.6", 
              "name": [
                "Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan", 
                "Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama 332-0012, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aburatani", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.0713466430.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713466430.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pathology, and,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niki", 
            "givenName": "Toshiro", 
            "id": "sg:person.01117336115.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117336115.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jichi Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of General Thoracic Surgery, Jichi Medical University, Tochigi 329-0498, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sohara", 
            "givenName": "Yasunori", 
            "id": "sg:person.0606231726.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606231726.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Pulmonary Medicine,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sugiyama", 
            "givenName": "Yukihiko", 
            "id": "sg:person.01053414201.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053414201.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Japan Science and Technology Agency", 
              "id": "https://www.grid.ac/institutes/grid.419082.6", 
              "name": [
                "Division of Functional Genomics,", 
                "Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama 332-0012, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mano", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.0776410617.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776410617.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0405220101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000546271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.3700348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003299424", 
              "https://doi.org/10.1038/labinvest.3700348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.3700348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003299424", 
              "https://doi.org/10.1038/labinvest.3700348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.3700348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003299424", 
              "https://doi.org/10.1038/labinvest.3700348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.10472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007101745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.10.080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008207423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m406082200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013283520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/canjclin.56.2.106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013642811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m106628200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014747697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015440801", 
              "https://doi.org/10.1038/sj.onc.1204594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015440801", 
              "https://doi.org/10.1038/sj.onc.1204594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.leukres.2006.05.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019733828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)62574-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020939102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200104053441401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026812584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0609412103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028004317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2006.06.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030391338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.21.12681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033028200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1099314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033538744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa040938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042907590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m106249200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047036202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2007.03.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048941041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(85)80053-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050892727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa011954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052159806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(99)01384-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053552724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0472954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055198436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0472954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055198436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm050824x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm050824x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8122112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074853877", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082690792", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082890118", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2007-08", 
        "datePublishedReg": "2007-08-01", 
        "description": "Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in non-small-cell lung cancer (NSCLC) cells. Mouse 3T3 fibroblasts forced to express this human fusion tyrosine kinase generated transformed foci in culture and subcutaneous tumours in nude mice. The EML4-ALK fusion transcript was detected in 6.7% (5 out of 75) of NSCLC patients examined; these individuals were distinct from those harbouring mutations in the epidermal growth factor receptor gene. Our data demonstrate that a subset of NSCLC patients may express a transforming fusion kinase that is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature05945", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7153", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "448"
          }
        ], 
        "name": "Identification of the transforming EML4\u2013ALK fusion gene in non-small-cell lung cancer", 
        "pagination": "561", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "520cf3d656370877740a3f94264c9ffae76345f482695ff4ea48a99edffcf5f9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "17625570"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature05945"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1017221313"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature05945", 
          "https://app.dimensions.ai/details/publication/pub.1017221313"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T18:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature05945"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature05945'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature05945'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature05945'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature05945'


     

    This table displays all metadata directly associated to this object as RDF triples.

    382 TRIPLES      21 PREDICATES      75 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature05945 schema:about N058dbbc562e941a8a82c4b053b6e8277
    2 N087d6e290af44edbb926763dee65c67d
    3 N0f1be870cf0f4fbebf985200f2ecd5f0
    4 N15d08ac7ea724506ad83f94a1f2f2e12
    5 N1838d788e9cc4fc1ac94e23aa7fe3643
    6 N1fec436dc8b14c50b660772ac5494194
    7 N29b6dd0bff9f4b99802cbeea7f1f3336
    8 N3c2f7877b1b740519fe7b6efba8eb35c
    9 N484cef09b48d47519fb588bc3eb63f28
    10 N653be588232447f2886def181783f8ae
    11 N6b005cd8ff6341e0965859f931cfb206
    12 N711927c2aed24bac8db68448cd2748a7
    13 N8797f6957a314a6bbe8202fb792bbdc7
    14 N938be05eed6b44a2807daa6f7bdef757
    15 Nadbe4f2167fe438da476319ade476b3b
    16 Nc83fbfb7657b40aca7d1ca4872c85690
    17 Nf3a4838260254b1ca8a9e42d1fe14b37
    18 Nf6c2262aa3154a8b96a2effa5a2f688e
    19 Nf79c99aeceed4933b6b08ef7a0a65234
    20 anzsrc-for:11
    21 anzsrc-for:1112
    22 schema:author N0deaea7349134973abbc0de44216c290
    23 schema:citation sg:pub.10.1038/labinvest.3700348
    24 sg:pub.10.1038/sj.onc.1204594
    25 https://app.dimensions.ai/details/publication/pub.1074853877
    26 https://app.dimensions.ai/details/publication/pub.1082690792
    27 https://app.dimensions.ai/details/publication/pub.1082890118
    28 https://doi.org/10.1002/jcp.10472
    29 https://doi.org/10.1016/j.bbrc.2005.10.080
    30 https://doi.org/10.1016/j.bbrc.2007.03.048
    31 https://doi.org/10.1016/j.leukres.2006.05.006
    32 https://doi.org/10.1016/j.yexcr.2006.06.035
    33 https://doi.org/10.1016/s0002-9440(10)62574-6
    34 https://doi.org/10.1016/s0092-8674(85)80053-2
    35 https://doi.org/10.1016/s0968-0004(99)01384-5
    36 https://doi.org/10.1021/bi0472954
    37 https://doi.org/10.1021/jm050824x
    38 https://doi.org/10.1056/nejm200104053441401
    39 https://doi.org/10.1056/nejmoa011954
    40 https://doi.org/10.1056/nejmoa040938
    41 https://doi.org/10.1073/pnas.0405220101
    42 https://doi.org/10.1073/pnas.0609412103
    43 https://doi.org/10.1074/jbc.271.21.12681
    44 https://doi.org/10.1074/jbc.m106249200
    45 https://doi.org/10.1074/jbc.m106628200
    46 https://doi.org/10.1074/jbc.m406082200
    47 https://doi.org/10.1126/science.1099314
    48 https://doi.org/10.1126/science.8122112
    49 https://doi.org/10.3322/canjclin.56.2.106
    50 schema:datePublished 2007-08
    51 schema:datePublishedReg 2007-08-01
    52 schema:description Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in non-small-cell lung cancer (NSCLC) cells. Mouse 3T3 fibroblasts forced to express this human fusion tyrosine kinase generated transformed foci in culture and subcutaneous tumours in nude mice. The EML4-ALK fusion transcript was detected in 6.7% (5 out of 75) of NSCLC patients examined; these individuals were distinct from those harbouring mutations in the epidermal growth factor receptor gene. Our data demonstrate that a subset of NSCLC patients may express a transforming fusion kinase that is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC.
    53 schema:genre research_article
    54 schema:inLanguage en
    55 schema:isAccessibleForFree false
    56 schema:isPartOf N6578ce025cc14a7581798c37aacead3a
    57 Ne568339ca2e94c74857ba407dcdc7267
    58 sg:journal.1018957
    59 schema:name Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
    60 schema:pagination 561
    61 schema:productId N313546018e384d8ba02a5aad902f3e7c
    62 N3322df90c20843b796324314ebd2b4bf
    63 Nab9b2cd0f75041b1b507f4937c62356b
    64 Ncac9d6ab4d684359a29c029b383327a0
    65 Neec72bef5b99430e99875910d224f4b3
    66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017221313
    67 https://doi.org/10.1038/nature05945
    68 schema:sdDatePublished 2019-04-10T18:56
    69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    70 schema:sdPublisher Ne5754b72494444ec93f5c5b97013c344
    71 schema:url https://www.nature.com/articles/nature05945
    72 sgo:license sg:explorer/license/
    73 sgo:sdDataset articles
    74 rdf:type schema:ScholarlyArticle
    75 N03815be6aade405c9a8e49cf6e1cf68d rdf:first sg:person.013043263602.16
    76 rdf:rest Nf4b75c2631f04ae5bad40be054e6dc3d
    77 N058dbbc562e941a8a82c4b053b6e8277 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    78 schema:name Molecular Sequence Data
    79 rdf:type schema:DefinedTerm
    80 N087d6e290af44edbb926763dee65c67d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    81 schema:name Protein-Tyrosine Kinases
    82 rdf:type schema:DefinedTerm
    83 N0d7bc1b248454f028d1daef8fcd50397 schema:name Division of Functional Genomics,
    84 rdf:type schema:Organization
    85 N0deaea7349134973abbc0de44216c290 rdf:first sg:person.01342673412.08
    86 rdf:rest Nb3e0aa78c0034b5fa3b0b9c1c49ff891
    87 N0f1be870cf0f4fbebf985200f2ecd5f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name Humans
    89 rdf:type schema:DefinedTerm
    90 N15d08ac7ea724506ad83f94a1f2f2e12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Cell Cycle Proteins
    92 rdf:type schema:DefinedTerm
    93 N1838d788e9cc4fc1ac94e23aa7fe3643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Chromosome Inversion
    95 rdf:type schema:DefinedTerm
    96 N1b21d869f291498281410187d573dffc rdf:first sg:person.0646104574.53
    97 rdf:rest N57c465e1718847618d881a9151f254c4
    98 N1beccf4610394135b3f74efe13e27ac1 schema:name Department of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
    99 rdf:type schema:Organization
    100 N1fec436dc8b14c50b660772ac5494194 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Cell Transformation, Neoplastic
    102 rdf:type schema:DefinedTerm
    103 N2540278602234f44a49017ab121719c9 schema:name Division of Functional Genomics,
    104 rdf:type schema:Organization
    105 N29b6dd0bff9f4b99802cbeea7f1f3336 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Amino Acid Sequence
    107 rdf:type schema:DefinedTerm
    108 N313546018e384d8ba02a5aad902f3e7c schema:name doi
    109 schema:value 10.1038/nature05945
    110 rdf:type schema:PropertyValue
    111 N3322df90c20843b796324314ebd2b4bf schema:name dimensions_id
    112 schema:value pub.1017221313
    113 rdf:type schema:PropertyValue
    114 N3c2f7877b1b740519fe7b6efba8eb35c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Carcinoma, Non-Small-Cell Lung
    116 rdf:type schema:DefinedTerm
    117 N3dff93430d8e44f483dee57d2b6c1779 schema:name Division of Functional Genomics,
    118 rdf:type schema:Organization
    119 N430c32648a3a4224a0f68f0254615d11 schema:name Division of Functional Genomics,
    120 Division of Pulmonary Medicine,
    121 rdf:type schema:Organization
    122 N484cef09b48d47519fb588bc3eb63f28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name 3T3 Cells
    124 rdf:type schema:DefinedTerm
    125 N527af80851a3423cb336a9a3e253d0fe rdf:first sg:person.01263547760.18
    126 rdf:rest Naac2d2ad1ec14ab6a4df93bc1a67c0fa
    127 N55a6aeae4f0c4dbf9c31dffb82e3ffb6 rdf:first sg:person.01117336115.41
    128 rdf:rest Nd02d6b71fe134a49a4c397fe98c601b5
    129 N57c465e1718847618d881a9151f254c4 rdf:first sg:person.0714217774.37
    130 rdf:rest Na3c40790c45b414d9c041136e2172d8b
    131 N5806bd1083504388920899fd38f3c2c3 rdf:first sg:person.01053414201.93
    132 rdf:rest N6d8f4696e081417abd079f49a6d35908
    133 N653be588232447f2886def181783f8ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Serine Endopeptidases
    135 rdf:type schema:DefinedTerm
    136 N6578ce025cc14a7581798c37aacead3a schema:volumeNumber 448
    137 rdf:type schema:PublicationVolume
    138 N6b005cd8ff6341e0965859f931cfb206 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Cell Proliferation
    140 rdf:type schema:DefinedTerm
    141 N6d8f4696e081417abd079f49a6d35908 rdf:first sg:person.0776410617.00
    142 rdf:rest rdf:nil
    143 N711927c2aed24bac8db68448cd2748a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Lung Neoplasms
    145 rdf:type schema:DefinedTerm
    146 N7ddaa0e4527f45fba2b5fa4998dd6770 schema:name Division of Pulmonary Medicine,
    147 rdf:type schema:Organization
    148 N7f506ffc43ca4cd1926b6703de7e52d4 schema:name Division of Functional Genomics,
    149 rdf:type schema:Organization
    150 N8797f6957a314a6bbe8202fb792bbdc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Receptor Protein-Tyrosine Kinases
    152 rdf:type schema:DefinedTerm
    153 N938be05eed6b44a2807daa6f7bdef757 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Mice
    155 rdf:type schema:DefinedTerm
    156 N97572bbbb42c4471b84c6940ddb505a2 schema:name Division of Pulmonary Medicine,
    157 rdf:type schema:Organization
    158 Na3c40790c45b414d9c041136e2172d8b rdf:first sg:person.01046231641.55
    159 rdf:rest N527af80851a3423cb336a9a3e253d0fe
    160 Na8be3b1c7e8640debadea223f2e98d85 schema:name Division of Functional Genomics,
    161 rdf:type schema:Organization
    162 Naac2d2ad1ec14ab6a4df93bc1a67c0fa rdf:first sg:person.01052511041.25
    163 rdf:rest Nfcd641a3c4bf4918946332b387ba4bb7
    164 Nab9b2cd0f75041b1b507f4937c62356b schema:name pubmed_id
    165 schema:value 17625570
    166 rdf:type schema:PropertyValue
    167 Nac07fb21a5394629ac51c08dc93d796e rdf:first sg:person.01076561574.24
    168 rdf:rest Nf0038ab057c54d0e9e2f8a4512704853
    169 Nadbe4f2167fe438da476319ade476b3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Chromosomes, Human, Pair 2
    171 rdf:type schema:DefinedTerm
    172 Nb3e0aa78c0034b5fa3b0b9c1c49ff891 rdf:first sg:person.011253172514.31
    173 rdf:rest Ndf32bf4e1982472d8d32c15ec5365622
    174 Nbbdde36a444944888f1b9e6e2d1d5ebf schema:name Division of Functional Genomics,
    175 Division of Pulmonary Medicine,
    176 rdf:type schema:Organization
    177 Nbe0cbf3cb3ef4bc58daa000c0a8e2dc2 schema:name Division of Pulmonary Medicine,
    178 rdf:type schema:Organization
    179 Nc83fbfb7657b40aca7d1ca4872c85690 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Microtubule-Associated Proteins
    181 rdf:type schema:DefinedTerm
    182 Ncac9d6ab4d684359a29c029b383327a0 schema:name nlm_unique_id
    183 schema:value 0410462
    184 rdf:type schema:PropertyValue
    185 Nd02d6b71fe134a49a4c397fe98c601b5 rdf:first sg:person.0606231726.88
    186 rdf:rest N5806bd1083504388920899fd38f3c2c3
    187 Ndceabc397a0047639c96e93a2372484b schema:name Department of Pathology, and,
    188 rdf:type schema:Organization
    189 Ndf32bf4e1982472d8d32c15ec5365622 rdf:first sg:person.01030446374.00
    190 rdf:rest Nac07fb21a5394629ac51c08dc93d796e
    191 Ne568339ca2e94c74857ba407dcdc7267 schema:issueNumber 7153
    192 rdf:type schema:PublicationIssue
    193 Ne5754b72494444ec93f5c5b97013c344 schema:name Springer Nature - SN SciGraph project
    194 rdf:type schema:Organization
    195 Neec72bef5b99430e99875910d224f4b3 schema:name readcube_id
    196 schema:value 520cf3d656370877740a3f94264c9ffae76345f482695ff4ea48a99edffcf5f9
    197 rdf:type schema:PropertyValue
    198 Nf0038ab057c54d0e9e2f8a4512704853 rdf:first sg:person.01356113147.74
    199 rdf:rest N03815be6aade405c9a8e49cf6e1cf68d
    200 Nf3a4838260254b1ca8a9e42d1fe14b37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Mutation
    202 rdf:type schema:DefinedTerm
    203 Nf3c7ff230f954ae19b6a8da33ea46e4a schema:name Division of Functional Genomics,
    204 rdf:type schema:Organization
    205 Nf4b75c2631f04ae5bad40be054e6dc3d rdf:first sg:person.01073536015.79
    206 rdf:rest N1b21d869f291498281410187d573dffc
    207 Nf631188fa1dd4cf7a87d6d402474c829 rdf:first sg:person.0713466430.47
    208 rdf:rest N55a6aeae4f0c4dbf9c31dffb82e3ffb6
    209 Nf6c2262aa3154a8b96a2effa5a2f688e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Oncogene Proteins, Fusion
    211 rdf:type schema:DefinedTerm
    212 Nf79c99aeceed4933b6b08ef7a0a65234 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Animals
    214 rdf:type schema:DefinedTerm
    215 Nf8556513fdf14c4ebe60668ed76b079d schema:name Division of Functional Genomics,
    216 rdf:type schema:Organization
    217 Nfcd641a3c4bf4918946332b387ba4bb7 rdf:first sg:person.01052642300.03
    218 rdf:rest Nf631188fa1dd4cf7a87d6d402474c829
    219 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    220 schema:name Medical and Health Sciences
    221 rdf:type schema:DefinedTerm
    222 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Oncology and Carcinogenesis
    224 rdf:type schema:DefinedTerm
    225 sg:journal.1018957 schema:issn 0090-0028
    226 1476-4687
    227 schema:name Nature
    228 rdf:type schema:Periodical
    229 sg:person.01030446374.00 schema:affiliation Nbbdde36a444944888f1b9e6e2d1d5ebf
    230 schema:familyName Enomoto
    231 schema:givenName Munehiro
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030446374.00
    233 rdf:type schema:Person
    234 sg:person.01046231641.55 schema:affiliation Na8be3b1c7e8640debadea223f2e98d85
    235 schema:familyName Hatanaka
    236 schema:givenName Hisashi
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046231641.55
    238 rdf:type schema:Person
    239 sg:person.01052511041.25 schema:affiliation Nbe0cbf3cb3ef4bc58daa000c0a8e2dc2
    240 schema:familyName Ohno
    241 schema:givenName Shoji
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052511041.25
    243 rdf:type schema:Person
    244 sg:person.01052642300.03 schema:affiliation N1beccf4610394135b3f74efe13e27ac1
    245 schema:familyName Ishikawa
    246 schema:givenName Yuichi
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052642300.03
    248 rdf:type schema:Person
    249 sg:person.01053414201.93 schema:affiliation N97572bbbb42c4471b84c6940ddb505a2
    250 schema:familyName Sugiyama
    251 schema:givenName Yukihiko
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053414201.93
    253 rdf:type schema:Person
    254 sg:person.01073536015.79 schema:affiliation Nf3c7ff230f954ae19b6a8da33ea46e4a
    255 schema:familyName Fujiwara
    256 schema:givenName Shin-ichiro
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073536015.79
    258 rdf:type schema:Person
    259 sg:person.01076561574.24 schema:affiliation Nf8556513fdf14c4ebe60668ed76b079d
    260 schema:familyName Takada
    261 schema:givenName Shuji
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076561574.24
    263 rdf:type schema:Person
    264 sg:person.01117336115.41 schema:affiliation Ndceabc397a0047639c96e93a2372484b
    265 schema:familyName Niki
    266 schema:givenName Toshiro
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117336115.41
    268 rdf:type schema:Person
    269 sg:person.011253172514.31 schema:affiliation N2540278602234f44a49017ab121719c9
    270 schema:familyName Choi
    271 schema:givenName Young Lim
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011253172514.31
    273 rdf:type schema:Person
    274 sg:person.01263547760.18 schema:affiliation N7ddaa0e4527f45fba2b5fa4998dd6770
    275 schema:familyName Bando
    276 schema:givenName Masashi
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263547760.18
    278 rdf:type schema:Person
    279 sg:person.013043263602.16 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    280 schema:familyName Ishikawa
    281 schema:givenName Shunpei
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013043263602.16
    283 rdf:type schema:Person
    284 sg:person.01342673412.08 schema:affiliation N430c32648a3a4224a0f68f0254615d11
    285 schema:familyName Soda
    286 schema:givenName Manabu
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342673412.08
    288 rdf:type schema:Person
    289 sg:person.01356113147.74 schema:affiliation N7f506ffc43ca4cd1926b6703de7e52d4
    290 schema:familyName Yamashita
    291 schema:givenName Yoshihiro
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356113147.74
    293 rdf:type schema:Person
    294 sg:person.0606231726.88 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
    295 schema:familyName Sohara
    296 schema:givenName Yasunori
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606231726.88
    298 rdf:type schema:Person
    299 sg:person.0646104574.53 schema:affiliation N3dff93430d8e44f483dee57d2b6c1779
    300 schema:familyName Watanabe
    301 schema:givenName Hideki
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646104574.53
    303 rdf:type schema:Person
    304 sg:person.0713466430.47 schema:affiliation https://www.grid.ac/institutes/grid.419082.6
    305 schema:familyName Aburatani
    306 schema:givenName Hiroyuki
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713466430.47
    308 rdf:type schema:Person
    309 sg:person.0714217774.37 schema:affiliation N0d7bc1b248454f028d1daef8fcd50397
    310 schema:familyName Kurashina
    311 schema:givenName Kentaro
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714217774.37
    313 rdf:type schema:Person
    314 sg:person.0776410617.00 schema:affiliation https://www.grid.ac/institutes/grid.419082.6
    315 schema:familyName Mano
    316 schema:givenName Hiroyuki
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776410617.00
    318 rdf:type schema:Person
    319 sg:pub.10.1038/labinvest.3700348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003299424
    320 https://doi.org/10.1038/labinvest.3700348
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/sj.onc.1204594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015440801
    323 https://doi.org/10.1038/sj.onc.1204594
    324 rdf:type schema:CreativeWork
    325 https://app.dimensions.ai/details/publication/pub.1074853877 schema:CreativeWork
    326 https://app.dimensions.ai/details/publication/pub.1082690792 schema:CreativeWork
    327 https://app.dimensions.ai/details/publication/pub.1082890118 schema:CreativeWork
    328 https://doi.org/10.1002/jcp.10472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007101745
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/j.bbrc.2005.10.080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008207423
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/j.bbrc.2007.03.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048941041
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/j.leukres.2006.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019733828
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/j.yexcr.2006.06.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030391338
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/s0002-9440(10)62574-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020939102
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1016/s0092-8674(85)80053-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050892727
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1016/s0968-0004(99)01384-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053552724
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1021/bi0472954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055198436
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1021/jm050824x schema:sameAs https://app.dimensions.ai/details/publication/pub.1055949825
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1056/nejm200104053441401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026812584
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1056/nejmoa011954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052159806
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1056/nejmoa040938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042907590
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1073/pnas.0405220101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000546271
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1073/pnas.0609412103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028004317
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1074/jbc.271.21.12681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033028200
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1074/jbc.m106249200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047036202
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1074/jbc.m106628200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014747697
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1074/jbc.m406082200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013283520
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1126/science.1099314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033538744
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1126/science.8122112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652848
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.3322/canjclin.56.2.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013642811
    371 rdf:type schema:CreativeWork
    372 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
    373 schema:name Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan
    374 rdf:type schema:Organization
    375 https://www.grid.ac/institutes/grid.410804.9 schema:alternateName Jichi Medical University
    376 schema:name Division of General Thoracic Surgery, Jichi Medical University, Tochigi 329-0498, Japan
    377 rdf:type schema:Organization
    378 https://www.grid.ac/institutes/grid.419082.6 schema:alternateName Japan Science and Technology Agency
    379 schema:name Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama 332-0012, Japan
    380 Division of Functional Genomics,
    381 Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan
    382 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...