Phenotypic plasticity and the epigenetics of human disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-05-24

AUTHORS

Andrew P Feinberg

ABSTRACT

It is becoming clear that epigenetic changes are involved in human disease as well as during normal development. A unifying theme of disease epigenetics is defects in phenotypic plasticity--cells' ability to change their behaviour in response to internal or external environmental cues. This model proposes that hereditary disorders of the epigenetic apparatus lead to developmental defects, that cancer epigenetics involves disruption of the stem-cell programme, and that common diseases with late-onset phenotypes involve interactions between the epigenome, the genome and the environment. Increased understanding of epigenetic-disease mechanisms could lead to disease-risk stratification for targeted intervention and to targeted therapies. More... »

PAGES

433-440

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05919

DOI

http://dx.doi.org/10.1038/nature05919

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033770262

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17522677


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