Developmental reprogramming after chromosome transfer into mitotic mouse zygotes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06-07

AUTHORS

Dieter Egli, Jacqueline Rosains, Garrett Birkhoff, Kevin Eggan

ABSTRACT

Until now, animal cloning and the production of embryonic stem cell lines by somatic cell nuclear transfer have relied on introducing nuclei into meiotic oocytes. In contrast, attempts at somatic cell nuclear transfer into fertilized interphase zygotes have failed. As a result, it has generally been assumed that unfertilized human oocytes will be required for the generation of tailored human embryonic stem cell lines from patients by somatic cell nuclear transfer. Here we report, however, that, unlike interphase zygotes, mouse zygotes temporarily arrested in mitosis can support somatic cell reprogramming, the production of embryonic stem cell lines and the full-term development of cloned animals. Thus, human zygotes and perhaps human embryonic blastomeres may be useful supplements to human oocytes for the creation of patient-derived human embryonic stem cells. More... »

PAGES

679

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05879

DOI

http://dx.doi.org/10.1038/nature05879

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003888215

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17554301


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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature05879'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature05879'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature05879'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature05879'


 

This table displays all metadata directly associated to this object as RDF triples.

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