Recovery of learning and memory is associated with chromatin remodelling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04-29

AUTHORS

Andre Fischer, Farahnaz Sananbenesi, Xinyu Wang, Matthew Dobbin, Li-Huei Tsai

ABSTRACT

Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. An important aspect in pre-clinical research is the exploration of strategies to re-establish learning ability and access to long-term memories. By using a mouse model that allows temporally and spatially restricted induction of neuronal loss, we show here that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred. Environmental enrichment correlated with chromatin modifications (increased histone-tail acetylation). Moreover, increased histone acetylation by inhibitors of histone deacetylases induced sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories. These data suggest that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment, and raises the possibility of recovery of long-term memories in patients with dementia. More... »

PAGES

178-182

Journal

TITLE

Nature

ISSUE

7141

VOLUME

447

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature05772

    DOI

    http://dx.doi.org/10.1038/nature05772

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17468743


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