A positive feedback mechanism governs the polarity and motion of motile cilia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04-22

AUTHORS

Brian Mitchell, Richard Jacobs, Julie Li, Shu Chien, Chris Kintner

ABSTRACT

On cells with motile cilia, cilia not only generate flow along a specific axis, but are involved in sensing and responding to that flow in a way that influences cell polarity. This model suggests a new paradigm for how polarity can be generated in a developing tissue, which will be of general interest to all developmental biologists. More... »

PAGES

97-101

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05771

DOI

http://dx.doi.org/10.1038/nature05771

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017156368

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17450123


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Patterning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Polarity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cilia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feedback, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Larva", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesoderm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenopus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Salk Institute for Biological Studies, La Jolla, California 92186, USA", 
          "id": "http://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "The Salk Institute for Biological Studies, La Jolla, California 92186, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitchell", 
        "givenName": "Brian", 
        "id": "sg:person.01037221622.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037221622.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute, USA", 
          "id": "http://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "The Salk Institute for Biological Studies, La Jolla, California 92186, USA", 
            "Howard Hughes Medical Institute, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacobs", 
        "givenName": "Richard", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Julie", 
        "id": "sg:person.01300357360.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300357360.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chien", 
        "givenName": "Shu", 
        "id": "sg:person.01114127615.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114127615.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Salk Institute for Biological Studies, La Jolla, California 92186, USA", 
          "id": "http://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "The Salk Institute for Biological Studies, La Jolla, California 92186, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kintner", 
        "givenName": "Chris", 
        "id": "sg:person.015460774341.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015460774341.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/79951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007182261", 
          "https://doi.org/10.1038/79951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02079527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021940235", 
          "https://doi.org/10.1007/bf02079527"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-04-22", 
    "datePublishedReg": "2007-04-22", 
    "description": "On cells with motile cilia, cilia not only generate flow along a specific axis, but are involved in sensing and responding to that flow in a way that influences cell polarity. This model suggests a new paradigm for how polarity can be generated in a developing tissue, which will be of general interest to all developmental biologists.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nature05771", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7140", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "447"
      }
    ], 
    "keywords": [
      "motile cilia", 
      "cell polarity", 
      "developmental biologists", 
      "cilia", 
      "positive feedback mechanism", 
      "biologists", 
      "polarity", 
      "feedback mechanism", 
      "cells", 
      "tissue", 
      "mechanism", 
      "new paradigm", 
      "general interest", 
      "specific axis", 
      "axis", 
      "interest", 
      "paradigm", 
      "model", 
      "way", 
      "flow", 
      "motion"
    ], 
    "name": "A positive feedback mechanism governs the polarity and motion of motile cilia", 
    "pagination": "97-101", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017156368"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature05771"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17450123"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature05771", 
      "https://app.dimensions.ai/details/publication/pub.1017156368"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_447.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nature05771"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature05771'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature05771'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature05771'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature05771'


 

This table displays all metadata directly associated to this object as RDF triples.

168 TRIPLES      21 PREDICATES      59 URIs      49 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature05771 schema:about N0829be03be5049a582009bcfd3a3b614
2 N0b7c5879ffe849158b220e668cd84242
3 N0be4414343584e1b9feb586f3b6782c7
4 N12cd7d27b3a944d4b1f3bca2976d1a48
5 N19a087b2b84841a89956eb0eee37beb6
6 N260e6ec8657c42ed8e3dd81cd4be0741
7 N2850c904d1304bb499032f4069068a54
8 N506da9c0255046d4b103f66c82129aff
9 Nde5cd23cf3e54c419885465184646746
10 Ne4b2101786ff4602aa8f019e522c5153
11 Nf1f800b58d3a4dc8a0e50d29968bdc57
12 anzsrc-for:06
13 anzsrc-for:0601
14 schema:author N7216d06de8db4bdaa31c988a3965a8ea
15 schema:citation sg:pub.10.1007/bf02079527
16 sg:pub.10.1038/79951
17 schema:datePublished 2007-04-22
18 schema:datePublishedReg 2007-04-22
19 schema:description On cells with motile cilia, cilia not only generate flow along a specific axis, but are involved in sensing and responding to that flow in a way that influences cell polarity. This model suggests a new paradigm for how polarity can be generated in a developing tissue, which will be of general interest to all developmental biologists.
20 schema:genre article
21 schema:isAccessibleForFree false
22 schema:isPartOf N212f69bf51384f4a8f17901e66660159
23 Naf432a63656b4ed2af1b0b1a17cc45a4
24 sg:journal.1018957
25 schema:keywords axis
26 biologists
27 cell polarity
28 cells
29 cilia
30 developmental biologists
31 feedback mechanism
32 flow
33 general interest
34 interest
35 mechanism
36 model
37 motile cilia
38 motion
39 new paradigm
40 paradigm
41 polarity
42 positive feedback mechanism
43 specific axis
44 tissue
45 way
46 schema:name A positive feedback mechanism governs the polarity and motion of motile cilia
47 schema:pagination 97-101
48 schema:productId N71ad1e4f6a374079ad86d009564c0bf1
49 N864d37ed2a3d416b8a8e739ca13e1dbe
50 Ndbb27f12972143c48aaafba14b144803
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017156368
52 https://doi.org/10.1038/nature05771
53 schema:sdDatePublished 2022-12-01T06:26
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher N6e0d55545af0446b936b6158f503d894
56 schema:url https://doi.org/10.1038/nature05771
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N0829be03be5049a582009bcfd3a3b614 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Feedback, Physiological
62 rdf:type schema:DefinedTerm
63 N0b7c5879ffe849158b220e668cd84242 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Cell Differentiation
65 rdf:type schema:DefinedTerm
66 N0be4414343584e1b9feb586f3b6782c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Animals
68 rdf:type schema:DefinedTerm
69 N12cd7d27b3a944d4b1f3bca2976d1a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Xenopus
71 rdf:type schema:DefinedTerm
72 N19a087b2b84841a89956eb0eee37beb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Larva
74 rdf:type schema:DefinedTerm
75 N212f69bf51384f4a8f17901e66660159 schema:volumeNumber 447
76 rdf:type schema:PublicationVolume
77 N260e6ec8657c42ed8e3dd81cd4be0741 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Cilia
79 rdf:type schema:DefinedTerm
80 N2850c904d1304bb499032f4069068a54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Skin
82 rdf:type schema:DefinedTerm
83 N506da9c0255046d4b103f66c82129aff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Movement
85 rdf:type schema:DefinedTerm
86 N6a0d610cdd684a35a3668e9f3800efb3 rdf:first Ne1a6ee5ebe274407b4e3a228b43c4312
87 rdf:rest Nd7e50ff8ffe24d09818dce1eaee46683
88 N6e0d55545af0446b936b6158f503d894 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N71ad1e4f6a374079ad86d009564c0bf1 schema:name pubmed_id
91 schema:value 17450123
92 rdf:type schema:PropertyValue
93 N7216d06de8db4bdaa31c988a3965a8ea rdf:first sg:person.01037221622.87
94 rdf:rest N6a0d610cdd684a35a3668e9f3800efb3
95 N864d37ed2a3d416b8a8e739ca13e1dbe schema:name doi
96 schema:value 10.1038/nature05771
97 rdf:type schema:PropertyValue
98 Naf432a63656b4ed2af1b0b1a17cc45a4 schema:issueNumber 7140
99 rdf:type schema:PublicationIssue
100 Nd7e50ff8ffe24d09818dce1eaee46683 rdf:first sg:person.01300357360.99
101 rdf:rest Nfe57712f104e45faa7d60290ecb54f51
102 Ndbb27f12972143c48aaafba14b144803 schema:name dimensions_id
103 schema:value pub.1017156368
104 rdf:type schema:PropertyValue
105 Nde5cd23cf3e54c419885465184646746 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Body Patterning
107 rdf:type schema:DefinedTerm
108 Ne1a6ee5ebe274407b4e3a228b43c4312 schema:affiliation grid-institutes:grid.413575.1
109 schema:familyName Jacobs
110 schema:givenName Richard
111 rdf:type schema:Person
112 Ne4b2101786ff4602aa8f019e522c5153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Cell Polarity
114 rdf:type schema:DefinedTerm
115 Nf1f800b58d3a4dc8a0e50d29968bdc57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Mesoderm
117 rdf:type schema:DefinedTerm
118 Nfc8b8ba5de82452aa63e2a0e91abcadf rdf:first sg:person.015460774341.09
119 rdf:rest rdf:nil
120 Nfe57712f104e45faa7d60290ecb54f51 rdf:first sg:person.01114127615.17
121 rdf:rest Nfc8b8ba5de82452aa63e2a0e91abcadf
122 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
123 schema:name Biological Sciences
124 rdf:type schema:DefinedTerm
125 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
126 schema:name Biochemistry and Cell Biology
127 rdf:type schema:DefinedTerm
128 sg:journal.1018957 schema:issn 0028-0836
129 1476-4687
130 schema:name Nature
131 schema:publisher Springer Nature
132 rdf:type schema:Periodical
133 sg:person.01037221622.87 schema:affiliation grid-institutes:grid.250671.7
134 schema:familyName Mitchell
135 schema:givenName Brian
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037221622.87
137 rdf:type schema:Person
138 sg:person.01114127615.17 schema:affiliation grid-institutes:grid.266100.3
139 schema:familyName Chien
140 schema:givenName Shu
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114127615.17
142 rdf:type schema:Person
143 sg:person.01300357360.99 schema:affiliation grid-institutes:grid.266100.3
144 schema:familyName Li
145 schema:givenName Julie
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300357360.99
147 rdf:type schema:Person
148 sg:person.015460774341.09 schema:affiliation grid-institutes:grid.250671.7
149 schema:familyName Kintner
150 schema:givenName Chris
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015460774341.09
152 rdf:type schema:Person
153 sg:pub.10.1007/bf02079527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021940235
154 https://doi.org/10.1007/bf02079527
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/79951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007182261
157 https://doi.org/10.1038/79951
158 rdf:type schema:CreativeWork
159 grid-institutes:grid.250671.7 schema:alternateName The Salk Institute for Biological Studies, La Jolla, California 92186, USA
160 schema:name The Salk Institute for Biological Studies, La Jolla, California 92186, USA
161 rdf:type schema:Organization
162 grid-institutes:grid.266100.3 schema:alternateName Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA
163 schema:name Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA
164 rdf:type schema:Organization
165 grid-institutes:grid.413575.1 schema:alternateName Howard Hughes Medical Institute, USA
166 schema:name Howard Hughes Medical Institute, USA
167 The Salk Institute for Biological Studies, La Jolla, California 92186, USA
168 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...