Tyrosine kinase receptor RET is a key regulator of Peyer’s Patch organogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03

AUTHORS

Henrique Veiga-Fernandes, Mark C. Coles, Katie E. Foster, Amisha Patel, Adam Williams, Dipa Natarajan, Amanda Barlow, Vassilis Pachnis, Dimitris Kioussis

ABSTRACT

Normal organogenesis requires co-ordinate development and interaction of multiple cell types, and is seemingly governed by tissue specific factors. Lymphoid organogenesis during embryonic life is dependent on molecules the temporal expression of which is tightly regulated. During this process, haematopoietic 'inducer' cells interact with stromal 'organizer' cells, giving rise to the lymphoid organ primordia. Here we show that the haematopoietic cells in the gut exhibit a random pattern of motility before aggregation into the primordia of Peyer's patches, a major component of the gut-associated lymphoid tissue. We further show that a CD45+CD4-CD3-Il7Ralpha-c-Kit+CD11c+ haematopoietic population expressing lymphotoxin has an important role in the formation of Peyer's patches. A subset of these cells expresses the receptor tyrosine kinase RET, which is essential for mammalian enteric nervous system formation. We demonstrate that RET signalling is also crucial for Peyer's patch formation. Functional genetic analysis revealed that Gfra3-deficiency results in impairment of Peyer's patch development, suggesting that the signalling axis RET/GFRalpha3/ARTN is involved in this process. To support this hypothesis, we show that the RET ligand ARTN is a strong attractant of gut haematopoietic cells, inducing the formation of ectopic Peyer's patch-like structures. Our work strongly suggests that the RET signalling pathway, by regulating the development of both the nervous and lymphoid system in the gut, has a key role in the molecular mechanisms that orchestrate intestine organogenesis. More... »

PAGES

547-551

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05597

DOI

http://dx.doi.org/10.1038/nature05597

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004912242

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17322904


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD2 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glial Cell Line-Derived Neurotrophic Factor Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peyer's Patches", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-ret", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Division of Molecular Immunology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Veiga-Fernandes", 
        "givenName": "Henrique", 
        "id": "sg:person.01162677021.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162677021.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Molecular Immunology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coles", 
        "givenName": "Mark C.", 
        "id": "sg:person.01036003275.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036003275.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Molecular Immunology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foster", 
        "givenName": "Katie E.", 
        "id": "sg:person.01106035513.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106035513.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Molecular Immunology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Amisha", 
        "id": "sg:person.0647600375.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647600375.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Molecular Immunology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Adam", 
        "id": "sg:person.01244021721.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244021721.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Natarajan", 
        "givenName": "Dipa", 
        "id": "sg:person.0747332420.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747332420.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barlow", 
        "givenName": "Amanda", 
        "id": "sg:person.01040742504.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040742504.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pachnis", 
        "givenName": "Vassilis", 
        "id": "sg:person.01223134326.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223134326.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Molecular Immunology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kioussis", 
        "givenName": "Dimitris", 
        "id": "sg:person.01133434421.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133434421.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.205001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000132525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.17.9302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002258066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/11.5.643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003805470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90047-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004958298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80292-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006905777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(02)00774-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008329343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80588-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015336876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.2890204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015586585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017023674", 
          "https://doi.org/10.1038/nri1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017023674", 
          "https://doi.org/10.1038/nri1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.18.10132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019683640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382076a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022258141", 
          "https://doi.org/10.1038/382076a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/10.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022928209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)80514-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022983512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0604183103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025072532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00365-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025836630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382073a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026862564", 
          "https://doi.org/10.1038/382073a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81798-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028129628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/9.4.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029378306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(01)80031-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030016933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35018581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031928930", 
          "https://doi.org/10.1038/35018581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35018581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031928930", 
          "https://doi.org/10.1038/35018581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.18.2412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033420908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367380a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037290893", 
          "https://doi.org/10.1038/367380a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.184.5.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039553480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90066-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039752418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.10.1467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043455245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045754219", 
          "https://doi.org/10.1038/17812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045754219", 
          "https://doi.org/10.1038/17812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80269-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046332930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/immu.200310005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050003873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/16852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050199905", 
          "https://doi.org/10.1038/16852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/16852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050199905", 
          "https://doi.org/10.1038/16852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8171322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.6.3702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074780133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.175.4.2301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077094004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082444115", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-03", 
    "datePublishedReg": "2007-03-01", 
    "description": "Normal organogenesis requires co-ordinate development and interaction of multiple cell types, and is seemingly governed by tissue specific factors. Lymphoid organogenesis during embryonic life is dependent on molecules the temporal expression of which is tightly regulated. During this process, haematopoietic 'inducer' cells interact with stromal 'organizer' cells, giving rise to the lymphoid organ primordia. Here we show that the haematopoietic cells in the gut exhibit a random pattern of motility before aggregation into the primordia of Peyer's patches, a major component of the gut-associated lymphoid tissue. We further show that a CD45+CD4-CD3-Il7Ralpha-c-Kit+CD11c+ haematopoietic population expressing lymphotoxin has an important role in the formation of Peyer's patches. A subset of these cells expresses the receptor tyrosine kinase RET, which is essential for mammalian enteric nervous system formation. We demonstrate that RET signalling is also crucial for Peyer's patch formation. Functional genetic analysis revealed that Gfra3-deficiency results in impairment of Peyer's patch development, suggesting that the signalling axis RET/GFRalpha3/ARTN is involved in this process. To support this hypothesis, we show that the RET ligand ARTN is a strong attractant of gut haematopoietic cells, inducing the formation of ectopic Peyer's patch-like structures. Our work strongly suggests that the RET signalling pathway, by regulating the development of both the nervous and lymphoid system in the gut, has a key role in the molecular mechanisms that orchestrate intestine organogenesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature05597", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2771102", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2763048", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2778587", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7135", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "446"
      }
    ], 
    "name": "Tyrosine kinase receptor RET is a key regulator of Peyer\u2019s Patch organogenesis", 
    "pagination": "547-551", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "17683be1342334e7f5cdc76831fc949d3e5ecf1519637c6ab5be8b317396a21b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17322904"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature05597"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004912242"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature05597", 
      "https://app.dimensions.ai/details/publication/pub.1004912242"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nature05597"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature05597'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature05597'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature05597'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature05597'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      21 PREDICATES      77 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature05597 schema:about N28c088fb88004c2394db7ae03893cd6f
2 N2adc29d306274b8c8bb46e41951540e5
3 N3d20cba84fc942c7a20d62adde4b4246
4 N5070646d071741a7bfb546e1c912b3b5
5 N599d7a2d3710428baee0884e49bebeab
6 N5c364ae8c4374765a94229cc6683259a
7 N63b0c9a858f448bea85927638353b9f7
8 N8697ff88591e4384a43afe1eb4697df9
9 Nb870d0c8b8fc402e94259398ce1145cd
10 Nd0d2c144be7344afbf102833c97c653e
11 Nd68e7d0901b74d4a9545af6bda495b3f
12 Ne4479934e51e4bdc8e7db737110a1705
13 Ne62d9d852c2e4a4e8c4499218739c1f2
14 Nf910eab47e35409b8a7893fe25885488
15 Nfb725f36abf242a4b7abbf80bed44186
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N60474351319944489909b366d7ce7abd
19 schema:citation sg:pub.10.1038/16852
20 sg:pub.10.1038/17812
21 sg:pub.10.1038/35018581
22 sg:pub.10.1038/367380a0
23 sg:pub.10.1038/382073a0
24 sg:pub.10.1038/382076a0
25 sg:pub.10.1038/nri1054
26 https://app.dimensions.ai/details/publication/pub.1082444115
27 https://doi.org/10.1002/immu.200310005
28 https://doi.org/10.1016/1074-7613(95)90047-0
29 https://doi.org/10.1016/1074-7613(95)90066-7
30 https://doi.org/10.1016/s0092-8674(00)81798-5
31 https://doi.org/10.1016/s0896-6273(00)80514-0
32 https://doi.org/10.1016/s0896-6273(01)80031-3
33 https://doi.org/10.1016/s0896-6273(02)00774-2
34 https://doi.org/10.1016/s1074-7613(00)80269-1
35 https://doi.org/10.1016/s1074-7613(00)80292-7
36 https://doi.org/10.1016/s1074-7613(00)80588-9
37 https://doi.org/10.1016/s1074-7613(02)00365-5
38 https://doi.org/10.1073/pnas.0604183103
39 https://doi.org/10.1073/pnas.94.17.9302
40 https://doi.org/10.1073/pnas.97.18.10132
41 https://doi.org/10.1084/jem.184.5.1999
42 https://doi.org/10.1084/jem.192.10.1467
43 https://doi.org/10.1093/intimm/10.1.1
44 https://doi.org/10.1093/intimm/11.5.643
45 https://doi.org/10.1093/intimm/9.4.507
46 https://doi.org/10.1101/gad.13.18.2412
47 https://doi.org/10.1101/gad.205001
48 https://doi.org/10.1101/gr.2890204
49 https://doi.org/10.1126/science.8171322
50 https://doi.org/10.4049/jimmunol.166.6.3702
51 https://doi.org/10.4049/jimmunol.175.4.2301
52 schema:datePublished 2007-03
53 schema:datePublishedReg 2007-03-01
54 schema:description Normal organogenesis requires co-ordinate development and interaction of multiple cell types, and is seemingly governed by tissue specific factors. Lymphoid organogenesis during embryonic life is dependent on molecules the temporal expression of which is tightly regulated. During this process, haematopoietic 'inducer' cells interact with stromal 'organizer' cells, giving rise to the lymphoid organ primordia. Here we show that the haematopoietic cells in the gut exhibit a random pattern of motility before aggregation into the primordia of Peyer's patches, a major component of the gut-associated lymphoid tissue. We further show that a CD45+CD4-CD3-Il7Ralpha-c-Kit+CD11c+ haematopoietic population expressing lymphotoxin has an important role in the formation of Peyer's patches. A subset of these cells expresses the receptor tyrosine kinase RET, which is essential for mammalian enteric nervous system formation. We demonstrate that RET signalling is also crucial for Peyer's patch formation. Functional genetic analysis revealed that Gfra3-deficiency results in impairment of Peyer's patch development, suggesting that the signalling axis RET/GFRalpha3/ARTN is involved in this process. To support this hypothesis, we show that the RET ligand ARTN is a strong attractant of gut haematopoietic cells, inducing the formation of ectopic Peyer's patch-like structures. Our work strongly suggests that the RET signalling pathway, by regulating the development of both the nervous and lymphoid system in the gut, has a key role in the molecular mechanisms that orchestrate intestine organogenesis.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf Na62a5a472696461a8e7bc35dcbb74f89
59 Nd4802050681e4199849748987823cf13
60 sg:journal.1018957
61 schema:name Tyrosine kinase receptor RET is a key regulator of Peyer’s Patch organogenesis
62 schema:pagination 547-551
63 schema:productId N0b8cf287a8e84e0eaa9600438ac40a2d
64 N1f73ccc2f2e341d8b0ab51a9be2c8f5e
65 N4763fc82a52e41e7ab6200a357716346
66 N6660707f25814ad2ab21910da21d85d8
67 Nc715e5f1671941a3bef39d4720cf6ab7
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004912242
69 https://doi.org/10.1038/nature05597
70 schema:sdDatePublished 2019-04-10T15:38
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Nd8beca53ff3344ffbb7df67a8e3de6dc
73 schema:url http://www.nature.com/articles/nature05597
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0b8cf287a8e84e0eaa9600438ac40a2d schema:name dimensions_id
78 schema:value pub.1004912242
79 rdf:type schema:PropertyValue
80 N128cf4ea771449f3bdfd42d6e7a12634 rdf:first sg:person.01040742504.43
81 rdf:rest N165a59d4203a432e96f0e8af8884773c
82 N165a59d4203a432e96f0e8af8884773c rdf:first sg:person.01223134326.92
83 rdf:rest N227b27ceeb76441096bf8f96dc80ca37
84 N1f73ccc2f2e341d8b0ab51a9be2c8f5e schema:name readcube_id
85 schema:value 17683be1342334e7f5cdc76831fc949d3e5ecf1519637c6ab5be8b317396a21b
86 rdf:type schema:PropertyValue
87 N227b27ceeb76441096bf8f96dc80ca37 rdf:first sg:person.01133434421.22
88 rdf:rest rdf:nil
89 N28c088fb88004c2394db7ae03893cd6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Cell Movement
91 rdf:type schema:DefinedTerm
92 N2adc29d306274b8c8bb46e41951540e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Mice
94 rdf:type schema:DefinedTerm
95 N3d20cba84fc942c7a20d62adde4b4246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Animals
97 rdf:type schema:DefinedTerm
98 N4763fc82a52e41e7ab6200a357716346 schema:name nlm_unique_id
99 schema:value 0410462
100 rdf:type schema:PropertyValue
101 N5070646d071741a7bfb546e1c912b3b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Proto-Oncogene Proteins c-ret
103 rdf:type schema:DefinedTerm
104 N599d7a2d3710428baee0884e49bebeab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Nerve Tissue Proteins
106 rdf:type schema:DefinedTerm
107 N5c364ae8c4374765a94229cc6683259a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Peyer's Patches
109 rdf:type schema:DefinedTerm
110 N5f43db1eda3e48638837b5cfc33fc638 schema:name Division of Molecular Immunology,
111 rdf:type schema:Organization
112 N60474351319944489909b366d7ce7abd rdf:first sg:person.01162677021.17
113 rdf:rest N9630dabe644543529077372246ab0776
114 N63b0c9a858f448bea85927638353b9f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Signal Transduction
116 rdf:type schema:DefinedTerm
117 N6660707f25814ad2ab21910da21d85d8 schema:name pubmed_id
118 schema:value 17322904
119 rdf:type schema:PropertyValue
120 N73557490522e455e85be3587f462dfb0 schema:name Division of Molecular Immunology,
121 rdf:type schema:Organization
122 N8697ff88591e4384a43afe1eb4697df9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Intestines
124 rdf:type schema:DefinedTerm
125 N8b5cf196f97d401da188d9996e654182 schema:name Division of Molecular Immunology,
126 rdf:type schema:Organization
127 N9630dabe644543529077372246ab0776 rdf:first sg:person.01036003275.86
128 rdf:rest Nbec4ee993a1940fa9f5c60d36e57216f
129 N97705848f0e840b092e5bde5af592696 rdf:first sg:person.0747332420.66
130 rdf:rest N128cf4ea771449f3bdfd42d6e7a12634
131 Na62a5a472696461a8e7bc35dcbb74f89 schema:volumeNumber 446
132 rdf:type schema:PublicationVolume
133 Nb870d0c8b8fc402e94259398ce1145cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Hematopoiesis
135 rdf:type schema:DefinedTerm
136 Nbec4ee993a1940fa9f5c60d36e57216f rdf:first sg:person.01106035513.03
137 rdf:rest Nfc6b62b7563a469cab0ef6ee030135a3
138 Nc715e5f1671941a3bef39d4720cf6ab7 schema:name doi
139 schema:value 10.1038/nature05597
140 rdf:type schema:PropertyValue
141 Ncaf8793752ac49efa9b5652eb456da18 schema:name Division of Molecular Immunology,
142 rdf:type schema:Organization
143 Nd0d2c144be7344afbf102833c97c653e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mice, Transgenic
145 rdf:type schema:DefinedTerm
146 Nd4802050681e4199849748987823cf13 schema:issueNumber 7135
147 rdf:type schema:PublicationIssue
148 Nd68e7d0901b74d4a9545af6bda495b3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Glial Cell Line-Derived Neurotrophic Factor Receptors
150 rdf:type schema:DefinedTerm
151 Nd77da20c21434928b231926638435967 rdf:first sg:person.01244021721.26
152 rdf:rest N97705848f0e840b092e5bde5af592696
153 Nd8beca53ff3344ffbb7df67a8e3de6dc schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 Ndf29052e5c9f4ec996a0ed8a8e7c1f19 schema:name Division of Molecular Immunology,
156 rdf:type schema:Organization
157 Ne4479934e51e4bdc8e7db737110a1705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mutation
159 rdf:type schema:DefinedTerm
160 Ne62d9d852c2e4a4e8c4499218739c1f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Organogenesis
162 rdf:type schema:DefinedTerm
163 Nf0352228b523487bba7d55a9eb8d3338 schema:name Division of Molecular Immunology,
164 rdf:type schema:Organization
165 Nf910eab47e35409b8a7893fe25885488 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name CD2 Antigens
167 rdf:type schema:DefinedTerm
168 Nfb725f36abf242a4b7abbf80bed44186 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Humans
170 rdf:type schema:DefinedTerm
171 Nfc6b62b7563a469cab0ef6ee030135a3 rdf:first sg:person.0647600375.18
172 rdf:rest Nd77da20c21434928b231926638435967
173 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
174 schema:name Biological Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biochemistry and Cell Biology
178 rdf:type schema:DefinedTerm
179 sg:grant.2763048 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05597
180 rdf:type schema:MonetaryGrant
181 sg:grant.2771102 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05597
182 rdf:type schema:MonetaryGrant
183 sg:grant.2778587 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05597
184 rdf:type schema:MonetaryGrant
185 sg:journal.1018957 schema:issn 0090-0028
186 1476-4687
187 schema:name Nature
188 rdf:type schema:Periodical
189 sg:person.01036003275.86 schema:affiliation Ncaf8793752ac49efa9b5652eb456da18
190 schema:familyName Coles
191 schema:givenName Mark C.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036003275.86
193 rdf:type schema:Person
194 sg:person.01040742504.43 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
195 schema:familyName Barlow
196 schema:givenName Amanda
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040742504.43
198 rdf:type schema:Person
199 sg:person.01106035513.03 schema:affiliation N8b5cf196f97d401da188d9996e654182
200 schema:familyName Foster
201 schema:givenName Katie E.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106035513.03
203 rdf:type schema:Person
204 sg:person.01133434421.22 schema:affiliation N5f43db1eda3e48638837b5cfc33fc638
205 schema:familyName Kioussis
206 schema:givenName Dimitris
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133434421.22
208 rdf:type schema:Person
209 sg:person.01162677021.17 schema:affiliation Nf0352228b523487bba7d55a9eb8d3338
210 schema:familyName Veiga-Fernandes
211 schema:givenName Henrique
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162677021.17
213 rdf:type schema:Person
214 sg:person.01223134326.92 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
215 schema:familyName Pachnis
216 schema:givenName Vassilis
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223134326.92
218 rdf:type schema:Person
219 sg:person.01244021721.26 schema:affiliation Ndf29052e5c9f4ec996a0ed8a8e7c1f19
220 schema:familyName Williams
221 schema:givenName Adam
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244021721.26
223 rdf:type schema:Person
224 sg:person.0647600375.18 schema:affiliation N73557490522e455e85be3587f462dfb0
225 schema:familyName Patel
226 schema:givenName Amisha
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647600375.18
228 rdf:type schema:Person
229 sg:person.0747332420.66 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
230 schema:familyName Natarajan
231 schema:givenName Dipa
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747332420.66
233 rdf:type schema:Person
234 sg:pub.10.1038/16852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050199905
235 https://doi.org/10.1038/16852
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/17812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045754219
238 https://doi.org/10.1038/17812
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/35018581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031928930
241 https://doi.org/10.1038/35018581
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/367380a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037290893
244 https://doi.org/10.1038/367380a0
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/382073a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026862564
247 https://doi.org/10.1038/382073a0
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/382076a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022258141
250 https://doi.org/10.1038/382076a0
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nri1054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017023674
253 https://doi.org/10.1038/nri1054
254 rdf:type schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1082444115 schema:CreativeWork
256 https://doi.org/10.1002/immu.200310005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050003873
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/1074-7613(95)90047-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004958298
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/1074-7613(95)90066-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039752418
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0092-8674(00)81798-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028129628
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0896-6273(00)80514-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022983512
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0896-6273(01)80031-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030016933
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0896-6273(02)00774-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008329343
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s1074-7613(00)80269-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046332930
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s1074-7613(00)80292-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006905777
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s1074-7613(00)80588-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015336876
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s1074-7613(02)00365-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025836630
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.0604183103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025072532
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.94.17.9302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002258066
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.97.18.10132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019683640
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1084/jem.184.5.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039553480
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1084/jem.192.10.1467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043455245
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/intimm/10.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022928209
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1093/intimm/11.5.643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003805470
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/intimm/9.4.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029378306
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1101/gad.13.18.2412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033420908
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1101/gad.205001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000132525
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1101/gr.2890204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015586585
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/science.8171322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653000
301 rdf:type schema:CreativeWork
302 https://doi.org/10.4049/jimmunol.166.6.3702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074780133
303 rdf:type schema:CreativeWork
304 https://doi.org/10.4049/jimmunol.175.4.2301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077094004
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
307 schema:name Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...