Structural definition of a conserved neutralization epitope on HIV-1 gp120 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-02

AUTHORS

Tongqing Zhou, Ling Xu, Barna Dey, Ann J. Hessell, Donald Van Ryk, Shi-Hua Xiang, Xinzhen Yang, Mei-Yun Zhang, Michael B. Zwick, James Arthos, Dennis R. Burton, Dimiter S. Dimitrov, Joseph Sodroski, Richard Wyatt, Gary J. Nabel, Peter D. Kwong

ABSTRACT

The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3 A resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally invariant surface that overlaps a distinct subset of the CD4-binding site. This surface is involved in the metastable attachment of CD4, before the gp120 rearrangement required for stable engagement. A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1. More... »

PAGES

732

Journal

TITLE

Nature

ISSUE

7129

VOLUME

445

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05580

DOI

http://dx.doi.org/10.1038/nature05580

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021005596

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17301785


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Conserved Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epitopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Envelope Protein gp120", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutralization Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Vaccine Research Center, and,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Tongqing", 
        "id": "sg:person.01062644176.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062644176.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Vaccine Research Center, and,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Ling", 
        "id": "sg:person.0743007631.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743007631.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Vaccine Research Center, and,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dey", 
        "givenName": "Barna", 
        "id": "sg:person.0777077503.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777077503.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scripps Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Departments of Immunology and Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hessell", 
        "givenName": "Ann J.", 
        "id": "sg:person.01203427457.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203427457.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Ryk", 
        "givenName": "Donald", 
        "id": "sg:person.01130507563.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130507563.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiang", 
        "givenName": "Shi-Hua", 
        "id": "sg:person.01337772551.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337772551.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Xinzhen", 
        "id": "sg:person.016622670537.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016622670537.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.417768.b", 
          "name": [
            "Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Mei-Yun", 
        "id": "sg:person.01102224047.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102224047.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scripps Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Departments of Immunology and Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zwick", 
        "givenName": "Michael B.", 
        "id": "sg:person.01203443254.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203443254.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arthos", 
        "givenName": "James", 
        "id": "sg:person.01146631715.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146631715.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scripps Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Departments of Immunology and Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burton", 
        "givenName": "Dennis R.", 
        "id": "sg:person.01215352065.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215352065.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.417768.b", 
          "name": [
            "Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dimitrov", 
        "givenName": "Dimiter S.", 
        "id": "sg:person.012247636637.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012247636637.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sodroski", 
        "givenName": "Joseph", 
        "id": "sg:person.01365275476.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365275476.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Vaccine Research Center, and,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wyatt", 
        "givenName": "Richard", 
        "id": "sg:person.0756353131.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756353131.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Vaccine Research Center, and,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nabel", 
        "givenName": "Gary J.", 
        "id": "sg:person.0724673736.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724673736.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Vaccine Research Center, and,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwong", 
        "givenName": "Peter D.", 
        "id": "sg:person.0612551152.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612551152.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1107/s0108767393007597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002475686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3233(02)61004-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003322155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2003.09.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004605733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.14.8828-8834.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004649896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.1999.4094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005545483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006143485", 
          "https://doi.org/10.1038/nature03327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006143485", 
          "https://doi.org/10.1038/nature03327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007469332", 
          "https://doi.org/10.1038/31514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007469332", 
          "https://doi.org/10.1038/31514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.77.10.5863-5876.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009109911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0263-7855(93)87010-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009554044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/387426a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010263645", 
          "https://doi.org/10.1038/387426a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(86)90778-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011715013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.2.623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017520519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.77.1.642-658.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018434897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018512919", 
          "https://doi.org/10.1038/nri891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018512919", 
          "https://doi.org/10.1038/nri891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1061692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019115978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/316069a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019333403", 
          "https://doi.org/10.1038/316069a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998003254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/312763a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021684259", 
          "https://doi.org/10.1038/312763a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444994003112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80205-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026125546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111191200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027632906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s002188989801053x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027775143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/289373a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032880486", 
          "https://doi.org/10.1038/289373a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033183450", 
          "https://doi.org/10.1038/nsmb1127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033183450", 
          "https://doi.org/10.1038/nsmb1127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033901538", 
          "https://doi.org/10.1038/nature01188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033901538", 
          "https://doi.org/10.1038/nature01188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0134(20000901)40:4<572::aid-prot30>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034873361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.17.8340-8347.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036284545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m600697200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036316081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.78.23.12975-12986.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036739473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199705000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037629119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199705000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037629119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038246480", 
          "https://doi.org/10.1038/31405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038246480", 
          "https://doi.org/10.1038/31405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.8.8.1696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041493857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/317145a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048446499", 
          "https://doi.org/10.1038/317145a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb1295-1075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049045339", 
          "https://doi.org/10.1038/nsb1295-1075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.7.4115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049251709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052007281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053047116", 
          "https://doi.org/10.1038/nature01470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053047116", 
          "https://doi.org/10.1038/nature01470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5263.872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5371.1884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.288.5472.1789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062569801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3629244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062620612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7973652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062650776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074664583", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077289673", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082375677", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082464955", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082855527", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083206072", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-02", 
    "datePublishedReg": "2007-02-01", 
    "description": "The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3 A resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally invariant surface that overlaps a distinct subset of the CD4-binding site. This surface is involved in the metastable attachment of CD4, before the gp120 rearrangement required for stable engagement. A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature05580", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2695801", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2709187", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2710662", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2709233", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2708971", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2709242", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7129", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "445"
      }
    ], 
    "name": "Structural definition of a conserved neutralization epitope on HIV-1 gp120", 
    "pagination": "732", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "641548ecc00c4832de3040c541a5af50c68c3348a6a94818f081e9f6813361aa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17301785"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature05580"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021005596"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature05580", 
      "https://app.dimensions.ai/details/publication/pub.1021005596"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature05580"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature05580'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature05580'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature05580'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature05580'


 

This table displays all metadata directly associated to this object as RDF triples.

408 TRIPLES      21 PREDICATES      89 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature05580 schema:about N005a0ad3740d41cd9805fb87170b6e8e
2 N25bc8a48f124475aa5fee7afc0d8da44
3 N70a824de94344c8c9505d6c0b804b8d5
4 N7259dc857a4e4da98b1d848d6067b76b
5 N7edc8cf3b3ec4b6ebe95c4903bd2d7bb
6 N8267fc6064cf42c88c0db28a2ad1c9ea
7 Naebfdf4388bd414d84c8f96da48072e5
8 Nc045c7bab6b44891ba49e68e28f2588d
9 Ndd600754b3074e01bed69c9655275887
10 Nf229f4a5a2234bf6b1f406c2cb685731
11 Nfd7cff7c4e9f47bba27162890c5d83f6
12 anzsrc-for:11
13 anzsrc-for:1107
14 schema:author N12ee30a881f24ce49217e8d4f928565b
15 schema:citation sg:pub.10.1038/289373a0
16 sg:pub.10.1038/312763a0
17 sg:pub.10.1038/31405
18 sg:pub.10.1038/31514
19 sg:pub.10.1038/316069a0
20 sg:pub.10.1038/317145a0
21 sg:pub.10.1038/387426a0
22 sg:pub.10.1038/nature01188
23 sg:pub.10.1038/nature01470
24 sg:pub.10.1038/nature03327
25 sg:pub.10.1038/nri891
26 sg:pub.10.1038/nsb1295-1075
27 sg:pub.10.1038/nsmb1127
28 https://app.dimensions.ai/details/publication/pub.1074664583
29 https://app.dimensions.ai/details/publication/pub.1077289673
30 https://app.dimensions.ai/details/publication/pub.1082375677
31 https://app.dimensions.ai/details/publication/pub.1082464955
32 https://app.dimensions.ai/details/publication/pub.1082855527
33 https://app.dimensions.ai/details/publication/pub.1083206072
34 https://doi.org/10.1002/1097-0134(20000901)40:4<572::aid-prot30>3.0.co;2-n
35 https://doi.org/10.1006/jsbi.1999.4094
36 https://doi.org/10.1016/0092-8674(86)90778-6
37 https://doi.org/10.1016/0263-7855(93)87010-3
38 https://doi.org/10.1016/j.jmb.2003.09.055
39 https://doi.org/10.1016/s0065-3233(02)61004-6
40 https://doi.org/10.1016/s0076-6879(97)76066-x
41 https://doi.org/10.1016/s0092-8674(00)80205-6
42 https://doi.org/10.1038/sj.emboj.7601358
43 https://doi.org/10.1073/pnas.97.2.623
44 https://doi.org/10.1074/jbc.274.7.4115
45 https://doi.org/10.1074/jbc.m111191200
46 https://doi.org/10.1074/jbc.m600697200
47 https://doi.org/10.1097/00002030-199705000-00006
48 https://doi.org/10.1107/s002188989801053x
49 https://doi.org/10.1107/s0108767393007597
50 https://doi.org/10.1107/s0907444994003112
51 https://doi.org/10.1107/s0907444998003254
52 https://doi.org/10.1110/ps.8.8.1696
53 https://doi.org/10.1126/science.1061692
54 https://doi.org/10.1126/science.272.5263.872
55 https://doi.org/10.1126/science.280.5371.1884
56 https://doi.org/10.1126/science.288.5472.1789
57 https://doi.org/10.1126/science.3629244
58 https://doi.org/10.1126/science.7973652
59 https://doi.org/10.1128/jvi.75.17.8340-8347.2001
60 https://doi.org/10.1128/jvi.77.1.642-658.2003
61 https://doi.org/10.1128/jvi.77.10.5863-5876.2003
62 https://doi.org/10.1128/jvi.78.23.12975-12986.2004
63 https://doi.org/10.1128/jvi.79.14.8828-8834.2005
64 schema:datePublished 2007-02
65 schema:datePublishedReg 2007-02-01
66 schema:description The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3 A resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally invariant surface that overlaps a distinct subset of the CD4-binding site. This surface is involved in the metastable attachment of CD4, before the gp120 rearrangement required for stable engagement. A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N20196c0e729c4a48bd37beda89f36746
71 Na2e8eb4f376d48588195c1ad53bc797e
72 sg:journal.1018957
73 schema:name Structural definition of a conserved neutralization epitope on HIV-1 gp120
74 schema:pagination 732
75 schema:productId N0137d1a59a10410286d80a82f1bae203
76 N15c2f9755ac3468da852cc67dfdba166
77 N1e34ea8bd2014e78bfa8e3407a5c93ef
78 N593f2bc3109e43d9af85ce29968698f6
79 Neacdfd163ba842edbde05fce0d963345
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021005596
81 https://doi.org/10.1038/nature05580
82 schema:sdDatePublished 2019-04-10T21:24
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N7fed4360603b48789d2ca230e1d40a6d
85 schema:url https://www.nature.com/articles/nature05580
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N005a0ad3740d41cd9805fb87170b6e8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Conserved Sequence
91 rdf:type schema:DefinedTerm
92 N0137d1a59a10410286d80a82f1bae203 schema:name pubmed_id
93 schema:value 17301785
94 rdf:type schema:PropertyValue
95 N07ec35143cbf4d9a987ab9ed621e18a5 rdf:first sg:person.01146631715.14
96 rdf:rest Neb097dfcd17e45cd8894891849ce45c2
97 N08c8d694d89d417daf4a440b3930c047 schema:name Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
98 rdf:type schema:Organization
99 N0947fc60b017407cb055a72e66528701 schema:name Vaccine Research Center, and,
100 rdf:type schema:Organization
101 N0ecca9c2ea9c4322a864e9df9d38037f rdf:first sg:person.0724673736.25
102 rdf:rest N9a3f6a2647a04197b9916a0fae36f25c
103 N12ee30a881f24ce49217e8d4f928565b rdf:first sg:person.01062644176.83
104 rdf:rest N75563f46199b47fb88a1828e457e8c2a
105 N15c2f9755ac3468da852cc67dfdba166 schema:name dimensions_id
106 schema:value pub.1021005596
107 rdf:type schema:PropertyValue
108 N1e34ea8bd2014e78bfa8e3407a5c93ef schema:name readcube_id
109 schema:value 641548ecc00c4832de3040c541a5af50c68c3348a6a94818f081e9f6813361aa
110 rdf:type schema:PropertyValue
111 N20196c0e729c4a48bd37beda89f36746 schema:volumeNumber 445
112 rdf:type schema:PublicationVolume
113 N25bc8a48f124475aa5fee7afc0d8da44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Epitopes
115 rdf:type schema:DefinedTerm
116 N40176c740aa44ab887922413522a2728 schema:name Vaccine Research Center, and,
117 rdf:type schema:Organization
118 N40a8a5dcba49410db9e2d133a4c21ca5 schema:name Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
119 rdf:type schema:Organization
120 N40ebd4aacc124b9da249c9632556c7eb rdf:first sg:person.01365275476.29
121 rdf:rest N71d3064befb14ed194b950f98792a1fe
122 N431196918b3c4097a73415d2f1316986 schema:name Vaccine Research Center, and,
123 rdf:type schema:Organization
124 N57e9b39d1fcd414db79b6ed609d74d65 rdf:first sg:person.012247636637.59
125 rdf:rest N40ebd4aacc124b9da249c9632556c7eb
126 N593f2bc3109e43d9af85ce29968698f6 schema:name nlm_unique_id
127 schema:value 0410462
128 rdf:type schema:PropertyValue
129 N677ae73ed9ad4c6f9811cffbcc3c01d3 rdf:first sg:person.01337772551.41
130 rdf:rest Ncbcccc2fefff4d32a26af594a0149774
131 N70a824de94344c8c9505d6c0b804b8d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name CD4 Antigens
133 rdf:type schema:DefinedTerm
134 N71d3064befb14ed194b950f98792a1fe rdf:first sg:person.0756353131.25
135 rdf:rest N0ecca9c2ea9c4322a864e9df9d38037f
136 N7259dc857a4e4da98b1d848d6067b76b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Molecular Weight
138 rdf:type schema:DefinedTerm
139 N75563f46199b47fb88a1828e457e8c2a rdf:first sg:person.0743007631.99
140 rdf:rest Na03ce55b67604cc093a5b9a6b5fb519b
141 N7edc8cf3b3ec4b6ebe95c4903bd2d7bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name HIV-1
143 rdf:type schema:DefinedTerm
144 N7fed4360603b48789d2ca230e1d40a6d schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N8267fc6064cf42c88c0db28a2ad1c9ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Models, Molecular
148 rdf:type schema:DefinedTerm
149 N9a3f6a2647a04197b9916a0fae36f25c rdf:first sg:person.0612551152.66
150 rdf:rest rdf:nil
151 N9c65a73597254889bd993a073eeb8f8e rdf:first sg:person.01130507563.26
152 rdf:rest N677ae73ed9ad4c6f9811cffbcc3c01d3
153 N9d465d4915a441bc8d6a967c0cb627a8 schema:name Vaccine Research Center, and,
154 rdf:type schema:Organization
155 N9f41fce23743464fb621e343cbadb98e rdf:first sg:person.01203427457.01
156 rdf:rest N9c65a73597254889bd993a073eeb8f8e
157 N9facc2fa3663476bb7e829a1fb697ef8 schema:name Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
158 rdf:type schema:Organization
159 Na03ce55b67604cc093a5b9a6b5fb519b rdf:first sg:person.0777077503.10
160 rdf:rest N9f41fce23743464fb621e343cbadb98e
161 Na2e8eb4f376d48588195c1ad53bc797e schema:issueNumber 7129
162 rdf:type schema:PublicationIssue
163 Naebfdf4388bd414d84c8f96da48072e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name HIV Envelope Protein gp120
165 rdf:type schema:DefinedTerm
166 Nb9c8d50c8f154c13a64f73dff1a30f80 schema:name Vaccine Research Center, and,
167 rdf:type schema:Organization
168 Nc045c7bab6b44891ba49e68e28f2588d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Protein Conformation
170 rdf:type schema:DefinedTerm
171 Nc6e57ca065234eadb872ba782ffa4622 rdf:first sg:person.01102224047.19
172 rdf:rest Nfcd0139616f54971937cd26c288f2afa
173 Ncbcccc2fefff4d32a26af594a0149774 rdf:first sg:person.016622670537.19
174 rdf:rest Nc6e57ca065234eadb872ba782ffa4622
175 Nd94dbc9a0a624a5eae3e9cf849d2aa06 schema:name Vaccine Research Center, and,
176 rdf:type schema:Organization
177 Ndd600754b3074e01bed69c9655275887 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Binding Sites
179 rdf:type schema:DefinedTerm
180 Neacdfd163ba842edbde05fce0d963345 schema:name doi
181 schema:value 10.1038/nature05580
182 rdf:type schema:PropertyValue
183 Neb097dfcd17e45cd8894891849ce45c2 rdf:first sg:person.01215352065.27
184 rdf:rest N57e9b39d1fcd414db79b6ed609d74d65
185 Nf229f4a5a2234bf6b1f406c2cb685731 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name HIV Antibodies
187 rdf:type schema:DefinedTerm
188 Nfcd0139616f54971937cd26c288f2afa rdf:first sg:person.01203443254.89
189 rdf:rest N07ec35143cbf4d9a987ab9ed621e18a5
190 Nfd7cff7c4e9f47bba27162890c5d83f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Neutralization Tests
192 rdf:type schema:DefinedTerm
193 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
194 schema:name Medical and Health Sciences
195 rdf:type schema:DefinedTerm
196 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
197 schema:name Immunology
198 rdf:type schema:DefinedTerm
199 sg:grant.2695801 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05580
200 rdf:type schema:MonetaryGrant
201 sg:grant.2708971 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05580
202 rdf:type schema:MonetaryGrant
203 sg:grant.2709187 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05580
204 rdf:type schema:MonetaryGrant
205 sg:grant.2709233 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05580
206 rdf:type schema:MonetaryGrant
207 sg:grant.2709242 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05580
208 rdf:type schema:MonetaryGrant
209 sg:grant.2710662 http://pending.schema.org/fundedItem sg:pub.10.1038/nature05580
210 rdf:type schema:MonetaryGrant
211 sg:journal.1018957 schema:issn 0090-0028
212 1476-4687
213 schema:name Nature
214 rdf:type schema:Periodical
215 sg:person.01062644176.83 schema:affiliation Nd94dbc9a0a624a5eae3e9cf849d2aa06
216 schema:familyName Zhou
217 schema:givenName Tongqing
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062644176.83
219 rdf:type schema:Person
220 sg:person.01102224047.19 schema:affiliation https://www.grid.ac/institutes/grid.417768.b
221 schema:familyName Zhang
222 schema:givenName Mei-Yun
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102224047.19
224 rdf:type schema:Person
225 sg:person.01130507563.26 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
226 schema:familyName Van Ryk
227 schema:givenName Donald
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130507563.26
229 rdf:type schema:Person
230 sg:person.01146631715.14 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
231 schema:familyName Arthos
232 schema:givenName James
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146631715.14
234 rdf:type schema:Person
235 sg:person.01203427457.01 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
236 schema:familyName Hessell
237 schema:givenName Ann J.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203427457.01
239 rdf:type schema:Person
240 sg:person.01203443254.89 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
241 schema:familyName Zwick
242 schema:givenName Michael B.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203443254.89
244 rdf:type schema:Person
245 sg:person.01215352065.27 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
246 schema:familyName Burton
247 schema:givenName Dennis R.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215352065.27
249 rdf:type schema:Person
250 sg:person.012247636637.59 schema:affiliation https://www.grid.ac/institutes/grid.417768.b
251 schema:familyName Dimitrov
252 schema:givenName Dimiter S.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012247636637.59
254 rdf:type schema:Person
255 sg:person.01337772551.41 schema:affiliation N40a8a5dcba49410db9e2d133a4c21ca5
256 schema:familyName Xiang
257 schema:givenName Shi-Hua
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337772551.41
259 rdf:type schema:Person
260 sg:person.01365275476.29 schema:affiliation N9facc2fa3663476bb7e829a1fb697ef8
261 schema:familyName Sodroski
262 schema:givenName Joseph
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365275476.29
264 rdf:type schema:Person
265 sg:person.016622670537.19 schema:affiliation N08c8d694d89d417daf4a440b3930c047
266 schema:familyName Yang
267 schema:givenName Xinzhen
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016622670537.19
269 rdf:type schema:Person
270 sg:person.0612551152.66 schema:affiliation N0947fc60b017407cb055a72e66528701
271 schema:familyName Kwong
272 schema:givenName Peter D.
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612551152.66
274 rdf:type schema:Person
275 sg:person.0724673736.25 schema:affiliation N431196918b3c4097a73415d2f1316986
276 schema:familyName Nabel
277 schema:givenName Gary J.
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724673736.25
279 rdf:type schema:Person
280 sg:person.0743007631.99 schema:affiliation N40176c740aa44ab887922413522a2728
281 schema:familyName Xu
282 schema:givenName Ling
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743007631.99
284 rdf:type schema:Person
285 sg:person.0756353131.25 schema:affiliation Nb9c8d50c8f154c13a64f73dff1a30f80
286 schema:familyName Wyatt
287 schema:givenName Richard
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756353131.25
289 rdf:type schema:Person
290 sg:person.0777077503.10 schema:affiliation N9d465d4915a441bc8d6a967c0cb627a8
291 schema:familyName Dey
292 schema:givenName Barna
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777077503.10
294 rdf:type schema:Person
295 sg:pub.10.1038/289373a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032880486
296 https://doi.org/10.1038/289373a0
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/312763a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021684259
299 https://doi.org/10.1038/312763a0
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/31405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038246480
302 https://doi.org/10.1038/31405
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/31514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007469332
305 https://doi.org/10.1038/31514
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/316069a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019333403
308 https://doi.org/10.1038/316069a0
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/317145a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048446499
311 https://doi.org/10.1038/317145a0
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/387426a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010263645
314 https://doi.org/10.1038/387426a0
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/nature01188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033901538
317 https://doi.org/10.1038/nature01188
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nature01470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053047116
320 https://doi.org/10.1038/nature01470
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/nature03327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006143485
323 https://doi.org/10.1038/nature03327
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/nri891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018512919
326 https://doi.org/10.1038/nri891
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/nsb1295-1075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049045339
329 https://doi.org/10.1038/nsb1295-1075
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/nsmb1127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033183450
332 https://doi.org/10.1038/nsmb1127
333 rdf:type schema:CreativeWork
334 https://app.dimensions.ai/details/publication/pub.1074664583 schema:CreativeWork
335 https://app.dimensions.ai/details/publication/pub.1077289673 schema:CreativeWork
336 https://app.dimensions.ai/details/publication/pub.1082375677 schema:CreativeWork
337 https://app.dimensions.ai/details/publication/pub.1082464955 schema:CreativeWork
338 https://app.dimensions.ai/details/publication/pub.1082855527 schema:CreativeWork
339 https://app.dimensions.ai/details/publication/pub.1083206072 schema:CreativeWork
340 https://doi.org/10.1002/1097-0134(20000901)40:4<572::aid-prot30>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1034873361
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1006/jsbi.1999.4094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005545483
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/0092-8674(86)90778-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011715013
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/0263-7855(93)87010-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009554044
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/j.jmb.2003.09.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004605733
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/s0065-3233(02)61004-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003322155
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/s0092-8674(00)80205-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026125546
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1038/sj.emboj.7601358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052007281
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1073/pnas.97.2.623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017520519
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1074/jbc.274.7.4115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049251709
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1074/jbc.m111191200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027632906
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1074/jbc.m600697200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036316081
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1097/00002030-199705000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037629119
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1107/s002188989801053x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027775143
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1107/s0108767393007597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002475686
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1107/s0907444994003112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573949
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1110/ps.8.8.1696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041493857
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1126/science.1061692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019115978
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1126/science.272.5263.872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552993
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1126/science.280.5371.1884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561487
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1126/science.288.5472.1789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062569801
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1126/science.3629244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062620612
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1126/science.7973652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650776
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1128/jvi.75.17.8340-8347.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036284545
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1128/jvi.77.1.642-658.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018434897
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1128/jvi.77.10.5863-5876.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009109911
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1128/jvi.78.23.12975-12986.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036739473
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1128/jvi.79.14.8828-8834.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004649896
399 rdf:type schema:CreativeWork
400 https://www.grid.ac/institutes/grid.214007.0 schema:alternateName Scripps Research Institute
401 schema:name Departments of Immunology and Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.417768.b schema:alternateName Center for Cancer Research
404 schema:name Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.419681.3 schema:alternateName National Institute of Allergy and Infectious Diseases
407 schema:name Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
408 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...