Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines View Full Text


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Article Info

DATE

2007-01-21

AUTHORS

Lindsey J. Macpherson, Adrienne E. Dubin, Michael J. Evans, Felix Marr, Peter G. Schultz, Benjamin F. Cravatt, Ardem Patapoutian

ABSTRACT

Sensing dangerThe TRPA1 ion channel, found in neurons associated with sensing pain, responds to noxious and pungent compounds and also to cold. Gene knockout experiments in mice confirm that TRPA1 is a physiologicallyrequired pain sensor. How such diverse stimuli activate TRPA1 was not known but Macpherson et al. show that that TRPA1 is activated by covalent modification of its cysteine residues. It is not unusual for proteins to be modified by cysteine reactive agents, but this is the first ion channel known to be activated by this method. The role of TRPA1 activation in response to electrophile toxicity and oxidative stress may be to warn the organism of potential tissue damage. More... »

PAGES

541-545

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05544

DOI

http://dx.doi.org/10.1038/nature05544

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020694555

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17237762


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