Inflammation and metabolic disorders View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-12

AUTHORS

Gökhan S Hotamisligil

ABSTRACT

Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare. More... »

PAGES

860-867

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  • Journal

    TITLE

    Nature

    ISSUE

    7121

    VOLUME

    444

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature05485

    DOI

    http://dx.doi.org/10.1038/nature05485

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042166283

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17167474


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