An obesity-associated gut microbiome with increased capacity for energy harvest View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-12

AUTHORS

Peter J. Turnbaugh, Ruth E. Ley, Michael A. Mahowald, Vincent Magrini, Elaine R. Mardis, Jeffrey I. Gordon

ABSTRACT

The worldwide obesity epidemic is stimulating efforts to identify host and environmental factors that affect energy balance. Comparisons of the distal gut microbiota of genetically obese mice and their lean littermates, as well as those of obese and lean human volunteers have revealed that obesity is associated with changes in the relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Here we demonstrate through metagenomic and biochemical analyses that these changes affect the metabolic potential of the mouse gut microbiota. Our results indicate that the obese microbiome has an increased capacity to harvest energy from the diet. Furthermore, this trait is transmissible: colonization of germ-free mice with an ‘obese microbiota’ results in a significantly greater increase in total body fat than colonization with a ‘lean microbiota’. These results identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity. More... »

PAGES

1027-1031

Journal

TITLE

Nature

ISSUE

7122

VOLUME

444

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature05414

    DOI

    http://dx.doi.org/10.1038/nature05414

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023893418

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17183312


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