Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-12

AUTHORS

S. G. M. Piccirillo, B. A. Reynolds, N. Zanetti, G. Lamorte, E. Binda, G. Broggi, H. Brem, A. Olivi, F. Dimeco, A. L. Vescovi

ABSTRACT

Transformed, oncogenic precursors, possessing both defining neural-stem-cell properties and the ability to initiate intracerebral tumours, have been identified in human brain cancers. Here we report that bone morphogenetic proteins (BMPs), amongst which BMP4 elicits the strongest effect, trigger a significant reduction in the stem-like, tumour-initiating precursors of human glioblastomas (GBMs). Transient in vitro exposure to BMP4 abolishes the capacity of transplanted GBM cells to establish intracerebral GBMs. Most importantly, in vivo delivery of BMP4 effectively blocks the tumour growth and associated mortality that occur in 100% of mice after intracerebral grafting of human GBM cells. We demonstrate that BMPs activate their cognate receptors (BMPRs) and trigger the Smad signalling cascade in cells isolated from human glioblastomas (GBMs). This is followed by a reduction in proliferation, and increased expression of markers of neural differentiation, with no effect on cell viability. The concomitant reduction in clonogenic ability, in the size of the CD133+ population and in the growth kinetics of GBM cells indicates that BMP4 reduces the tumour-initiating cell pool of GBMs. These findings show that the BMP-BMPR signalling system--which controls the activity of normal brain stem cells--may also act as a key inhibitory regulator of tumour-initiating, stem-like cells from GBMs and the results also identify BMP4 as a novel, non-cytotoxic therapeutic effector, which may be used to prevent growth and recurrence of GBMs in humans. More... »

PAGES

761

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05349

DOI

http://dx.doi.org/10.1038/nature05349

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032950201

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17151667


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AC133 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Protein 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Protein Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Milano-Bicocca", 
          "id": "https://www.grid.ac/institutes/grid.7563.7", 
          "name": [
            "Department of Biotechnology and Biosciences, University of Milan\u2013Bicocca, 20126 Milan, Italy", 
            "Unit of Cancer Stem Cell Biology, StemGen Spa, University of Milan\u2013Bicocca, 20126 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piccirillo", 
        "givenName": "S. G. M.", 
        "id": "sg:person.014676111567.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014676111567.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "Laboratory for Neural Stem Cell Biology, Queensland Brain Institute, University of Queensland, 4072 Brisbane, Queensland, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reynolds", 
        "givenName": "B. A.", 
        "id": "sg:person.0612774233.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612774233.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milano-Bicocca", 
          "id": "https://www.grid.ac/institutes/grid.7563.7", 
          "name": [
            "Unit of Cancer Stem Cell Biology, StemGen Spa, University of Milan\u2013Bicocca, 20126 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zanetti", 
        "givenName": "N.", 
        "id": "sg:person.0746514710.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746514710.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milano-Bicocca", 
          "id": "https://www.grid.ac/institutes/grid.7563.7", 
          "name": [
            "Unit of Cancer Stem Cell Biology, StemGen Spa, University of Milan\u2013Bicocca, 20126 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamorte", 
        "givenName": "G.", 
        "id": "sg:person.01241444010.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241444010.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Research Institute, H. S. Raffaele, 20132 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Binda", 
        "givenName": "E.", 
        "id": "sg:person.01057102210.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057102210.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Neurologico Carlo Besta", 
          "id": "https://www.grid.ac/institutes/grid.417894.7", 
          "name": [
            "National Neurological Institute \u2018C. Besta\u2019, 20133 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broggi", 
        "givenName": "G.", 
        "id": "sg:person.01155437104.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155437104.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Neurosurgery, John Hopkins University, Baltimore, 21287 Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brem", 
        "givenName": "H.", 
        "id": "sg:person.0656171054.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656171054.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Neurosurgery, John Hopkins University, Baltimore, 21287 Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olivi", 
        "givenName": "A.", 
        "id": "sg:person.01370304457.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370304457.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "National Neurological Institute \u2018C. Besta\u2019, 20133 Milan, Italy", 
            "Department of Neurosurgery, John Hopkins University, Baltimore, 21287 Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dimeco", 
        "givenName": "F.", 
        "id": "sg:person.0656152606.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656152606.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milano-Bicocca", 
          "id": "https://www.grid.ac/institutes/grid.7563.7", 
          "name": [
            "Department of Biotechnology and Biosciences, University of Milan\u2013Bicocca, 20126 Milan, Italy", 
            "Unit of Cancer Stem Cell Biology, StemGen Spa, University of Milan\u2013Bicocca, 20126 Milan, Italy", 
            "Stem Cell Research Institute, H. S. Raffaele, 20132 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vescovi", 
        "givenName": "A. L.", 
        "id": "sg:person.01117223140.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117223140.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/1097-0215(20000520)89:3<251::aid-ijc7>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000682292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009107668", 
          "https://doi.org/10.1038/nrc1232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009107668", 
          "https://doi.org/10.1038/nrc1232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2002-0023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010343286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2036535100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012172628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1996.0090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014800916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2004.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014822447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1998.6998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018588470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0530291100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018724794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35102167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021100179", 
          "https://doi.org/10.1038/35102167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35102167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021100179", 
          "https://doi.org/10.1038/35102167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027226854", 
          "https://doi.org/10.1038/nature03128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027226854", 
          "https://doi.org/10.1038/nature03128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367645a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028822583", 
          "https://doi.org/10.1038/367645a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029990219", 
          "https://doi.org/10.1038/sj.onc.1208925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029990219", 
          "https://doi.org/10.1038/sj.onc.1208925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029990219", 
          "https://doi.org/10.1038/sj.onc.1208925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.10094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030472330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035138833", 
          "https://doi.org/10.1038/nrc1889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035138833", 
          "https://doi.org/10.1038/nrc1889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037193002", 
          "https://doi.org/10.1038/nm904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037193002", 
          "https://doi.org/10.1038/nm904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037605769", 
          "https://doi.org/10.1038/nmeth758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037605769", 
          "https://doi.org/10.1038/nmeth758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08977190412331279890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039553454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040457475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200211021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040597604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81112-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041353219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4547(19990501)56:3<248::aid-jnr4>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045765316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)00148-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046424399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(02)00329-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047397188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049812195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049812195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050924893", 
          "https://doi.org/10.1038/nrc1590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050924893", 
          "https://doi.org/10.1038/nrc1590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006123-199804000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060247414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078267826", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-23-07599.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082999399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083103523", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.18-21-08853.1998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083335765"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-12", 
    "datePublishedReg": "2006-12-01", 
    "description": "Transformed, oncogenic precursors, possessing both defining neural-stem-cell properties and the ability to initiate intracerebral tumours, have been identified in human brain cancers. Here we report that bone morphogenetic proteins (BMPs), amongst which BMP4 elicits the strongest effect, trigger a significant reduction in the stem-like, tumour-initiating precursors of human glioblastomas (GBMs). Transient in vitro exposure to BMP4 abolishes the capacity of transplanted GBM cells to establish intracerebral GBMs. Most importantly, in vivo delivery of BMP4 effectively blocks the tumour growth and associated mortality that occur in 100% of mice after intracerebral grafting of human GBM cells. We demonstrate that BMPs activate their cognate receptors (BMPRs) and trigger the Smad signalling cascade in cells isolated from human glioblastomas (GBMs). This is followed by a reduction in proliferation, and increased expression of markers of neural differentiation, with no effect on cell viability. The concomitant reduction in clonogenic ability, in the size of the CD133+ population and in the growth kinetics of GBM cells indicates that BMP4 reduces the tumour-initiating cell pool of GBMs. These findings show that the BMP-BMPR signalling system--which controls the activity of normal brain stem cells--may also act as a key inhibitory regulator of tumour-initiating, stem-like cells from GBMs and the results also identify BMP4 as a novel, non-cytotoxic therapeutic effector, which may be used to prevent growth and recurrence of GBMs in humans.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature05349", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7120", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "444"
      }
    ], 
    "name": "Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells", 
    "pagination": "761", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9cf86dba13a47e5b86d18689682045a9dca428f3b6c92e9b65e2254bf214aa72"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17151667"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature05349"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032950201"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature05349", 
      "https://app.dimensions.ai/details/publication/pub.1032950201"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000365_0000000365/records_71714_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature05349"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature05349'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature05349'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature05349'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature05349'


 

This table displays all metadata directly associated to this object as RDF triples.

315 TRIPLES      21 PREDICATES      77 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature05349 schema:about N0a1a7020aac0467286fff1434131f85d
2 N3364e695ddb04e739fe065e8d6f00f78
3 N532092c50e1446cf9d37478105df3669
4 N5524aa89d96e48d990c34f336f20538e
5 N56a275f113d84d34b40eb946d29daae4
6 N5ea12b27cdf1456bb6d89ce0d500d819
7 N61f62c719bcd4eb492ac48ac19a49d43
8 N6ace4d7d28b648fab047c9e382ff0ce5
9 N6b20b15a70d547cf88816593237b0ba9
10 N732a854c7e474090a0d5a0c7a4e8ff39
11 N8fcf631e0e484517887aa18f028d3224
12 N91d3ebd1caf945e195e26e4ee17b135b
13 N924c53bd15ae45cca59f8bb52f5765b1
14 N92a43da92c4046b79be8205c47c1f867
15 Nb33956200f1c483382f5474677f00b69
16 Nc38dcce6b3f5497dbd2eff723ac574eb
17 Ncbf171c8fae445a99ccea3af745ad61e
18 Ne9c95c35bca043ce8f4a4cda4b00d952
19 anzsrc-for:11
20 anzsrc-for:1109
21 schema:author N765eb48f66a44e81bb66d39a7b28c225
22 schema:citation sg:pub.10.1038/35102167
23 sg:pub.10.1038/367645a0
24 sg:pub.10.1038/nature03128
25 sg:pub.10.1038/nm904
26 sg:pub.10.1038/nmeth758
27 sg:pub.10.1038/nrc1232
28 sg:pub.10.1038/nrc1590
29 sg:pub.10.1038/nrc1889
30 sg:pub.10.1038/sj.onc.1208925
31 https://app.dimensions.ai/details/publication/pub.1078267826
32 https://app.dimensions.ai/details/publication/pub.1083103523
33 https://doi.org/10.1002/(sici)1097-4547(19990501)56:3<248::aid-jnr4>3.0.co;2-u
34 https://doi.org/10.1002/1097-0215(20000520)89:3<251::aid-ijc7>3.0.co;2-5
35 https://doi.org/10.1002/glia.10094
36 https://doi.org/10.1006/dbio.1996.0090
37 https://doi.org/10.1006/exnr.1998.6998
38 https://doi.org/10.1016/j.ccr.2005.09.001
39 https://doi.org/10.1016/j.critrevonc.2004.04.007
40 https://doi.org/10.1016/s0092-8674(00)81112-5
41 https://doi.org/10.1016/s0896-6273(00)00148-3
42 https://doi.org/10.1016/s0959-437x(02)00329-5
43 https://doi.org/10.1073/pnas.0530291100
44 https://doi.org/10.1073/pnas.2036535100
45 https://doi.org/10.1080/08977190412331279890
46 https://doi.org/10.1083/jcb.200211021
47 https://doi.org/10.1097/00006123-199804000-00013
48 https://doi.org/10.1158/0008-5472.can-04-1364
49 https://doi.org/10.1210/er.2002-0023
50 https://doi.org/10.1523/jneurosci.16-23-07599.1996
51 https://doi.org/10.1523/jneurosci.18-21-08853.1998
52 schema:datePublished 2006-12
53 schema:datePublishedReg 2006-12-01
54 schema:description Transformed, oncogenic precursors, possessing both defining neural-stem-cell properties and the ability to initiate intracerebral tumours, have been identified in human brain cancers. Here we report that bone morphogenetic proteins (BMPs), amongst which BMP4 elicits the strongest effect, trigger a significant reduction in the stem-like, tumour-initiating precursors of human glioblastomas (GBMs). Transient in vitro exposure to BMP4 abolishes the capacity of transplanted GBM cells to establish intracerebral GBMs. Most importantly, in vivo delivery of BMP4 effectively blocks the tumour growth and associated mortality that occur in 100% of mice after intracerebral grafting of human GBM cells. We demonstrate that BMPs activate their cognate receptors (BMPRs) and trigger the Smad signalling cascade in cells isolated from human glioblastomas (GBMs). This is followed by a reduction in proliferation, and increased expression of markers of neural differentiation, with no effect on cell viability. The concomitant reduction in clonogenic ability, in the size of the CD133+ population and in the growth kinetics of GBM cells indicates that BMP4 reduces the tumour-initiating cell pool of GBMs. These findings show that the BMP-BMPR signalling system--which controls the activity of normal brain stem cells--may also act as a key inhibitory regulator of tumour-initiating, stem-like cells from GBMs and the results also identify BMP4 as a novel, non-cytotoxic therapeutic effector, which may be used to prevent growth and recurrence of GBMs in humans.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N00439e62a6f5488eb6de604a74beeae5
59 N81135153d77c447a8fbcf42ce31b20b9
60 sg:journal.1018957
61 schema:name Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
62 schema:pagination 761
63 schema:productId N01cad1a90077482c92eaf577ce0d25d6
64 N495b615b87fb4350bc60f753a40b9565
65 N71ac881754e54a4399a3c7620d557017
66 Na115a641071343e18eb2e35e47f3e14c
67 Nec9f4239b6764e619a8dee7f985eaf29
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032950201
69 https://doi.org/10.1038/nature05349
70 schema:sdDatePublished 2019-04-11T13:01
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N03bd32e362d345de8e46cff38fc22bef
73 schema:url https://www.nature.com/articles/nature05349
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N00439e62a6f5488eb6de604a74beeae5 schema:volumeNumber 444
78 rdf:type schema:PublicationVolume
79 N01cad1a90077482c92eaf577ce0d25d6 schema:name pubmed_id
80 schema:value 17151667
81 rdf:type schema:PropertyValue
82 N03bd32e362d345de8e46cff38fc22bef schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N0a1a7020aac0467286fff1434131f85d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Antigens, CD
86 rdf:type schema:DefinedTerm
87 N1f4f45451a784286a32ebfc9892439b4 rdf:first sg:person.0656152606.56
88 rdf:rest N92048e5909af42a4bc743af331058a24
89 N2a254a640e17466cb5466179cbcc9548 rdf:first sg:person.0746514710.09
90 rdf:rest Nf5929045cdb449f6992b8b8e2f542f43
91 N30cdc251eb8a49b3b799c66c4e0b47bf schema:name Stem Cell Research Institute, H. S. Raffaele, 20132 Milan, Italy
92 rdf:type schema:Organization
93 N3364e695ddb04e739fe065e8d6f00f78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Bone Morphogenetic Protein 4
95 rdf:type schema:DefinedTerm
96 N495b615b87fb4350bc60f753a40b9565 schema:name readcube_id
97 schema:value 9cf86dba13a47e5b86d18689682045a9dca428f3b6c92e9b65e2254bf214aa72
98 rdf:type schema:PropertyValue
99 N532092c50e1446cf9d37478105df3669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Cell Proliferation
101 rdf:type schema:DefinedTerm
102 N5524aa89d96e48d990c34f336f20538e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Bone Morphogenetic Protein Receptors
104 rdf:type schema:DefinedTerm
105 N56a275f113d84d34b40eb946d29daae4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Brain Neoplasms
107 rdf:type schema:DefinedTerm
108 N5ea12b27cdf1456bb6d89ce0d500d819 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Glycoproteins
110 rdf:type schema:DefinedTerm
111 N61f62c719bcd4eb492ac48ac19a49d43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Neoplastic Stem Cells
113 rdf:type schema:DefinedTerm
114 N682eef0ae2874ad281884c9e16120ba4 rdf:first sg:person.01057102210.67
115 rdf:rest N93b5cb51fae44a8b853bc625d9723e35
116 N6ace4d7d28b648fab047c9e382ff0ce5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Stem Cell Transplantation
118 rdf:type schema:DefinedTerm
119 N6b20b15a70d547cf88816593237b0ba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Peptides
121 rdf:type schema:DefinedTerm
122 N71ac881754e54a4399a3c7620d557017 schema:name nlm_unique_id
123 schema:value 0410462
124 rdf:type schema:PropertyValue
125 N732a854c7e474090a0d5a0c7a4e8ff39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mice
127 rdf:type schema:DefinedTerm
128 N765eb48f66a44e81bb66d39a7b28c225 rdf:first sg:person.014676111567.21
129 rdf:rest Nc6bf52fb56cd423fb987e8484af7cac1
130 N81135153d77c447a8fbcf42ce31b20b9 schema:issueNumber 7120
131 rdf:type schema:PublicationIssue
132 N8fcf631e0e484517887aa18f028d3224 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Bone Morphogenetic Proteins
134 rdf:type schema:DefinedTerm
135 N91d3ebd1caf945e195e26e4ee17b135b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cell Differentiation
137 rdf:type schema:DefinedTerm
138 N92048e5909af42a4bc743af331058a24 rdf:first sg:person.01117223140.60
139 rdf:rest rdf:nil
140 N924c53bd15ae45cca59f8bb52f5765b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cell Line
142 rdf:type schema:DefinedTerm
143 N92a43da92c4046b79be8205c47c1f867 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 N93b5cb51fae44a8b853bc625d9723e35 rdf:first sg:person.01155437104.54
147 rdf:rest Na7df28c726de43cda290940c2c925cde
148 Na115a641071343e18eb2e35e47f3e14c schema:name doi
149 schema:value 10.1038/nature05349
150 rdf:type schema:PropertyValue
151 Na7df28c726de43cda290940c2c925cde rdf:first sg:person.0656171054.01
152 rdf:rest Nfb9fe48f23104d0c86c5cdc24aa0a14f
153 Nb33956200f1c483382f5474677f00b69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Glioblastoma
155 rdf:type schema:DefinedTerm
156 Nc38dcce6b3f5497dbd2eff723ac574eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Signal Transduction
158 rdf:type schema:DefinedTerm
159 Nc6bf52fb56cd423fb987e8484af7cac1 rdf:first sg:person.0612774233.53
160 rdf:rest N2a254a640e17466cb5466179cbcc9548
161 Ncbf171c8fae445a99ccea3af745ad61e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Animals
163 rdf:type schema:DefinedTerm
164 Ne9c95c35bca043ce8f4a4cda4b00d952 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name AC133 Antigen
166 rdf:type schema:DefinedTerm
167 Nec9f4239b6764e619a8dee7f985eaf29 schema:name dimensions_id
168 schema:value pub.1032950201
169 rdf:type schema:PropertyValue
170 Nf5929045cdb449f6992b8b8e2f542f43 rdf:first sg:person.01241444010.35
171 rdf:rest N682eef0ae2874ad281884c9e16120ba4
172 Nfb9fe48f23104d0c86c5cdc24aa0a14f rdf:first sg:person.01370304457.69
173 rdf:rest N1f4f45451a784286a32ebfc9892439b4
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
178 schema:name Neurosciences
179 rdf:type schema:DefinedTerm
180 sg:journal.1018957 schema:issn 0090-0028
181 1476-4687
182 schema:name Nature
183 rdf:type schema:Periodical
184 sg:person.01057102210.67 schema:affiliation N30cdc251eb8a49b3b799c66c4e0b47bf
185 schema:familyName Binda
186 schema:givenName E.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057102210.67
188 rdf:type schema:Person
189 sg:person.01117223140.60 schema:affiliation https://www.grid.ac/institutes/grid.7563.7
190 schema:familyName Vescovi
191 schema:givenName A. L.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117223140.60
193 rdf:type schema:Person
194 sg:person.01155437104.54 schema:affiliation https://www.grid.ac/institutes/grid.417894.7
195 schema:familyName Broggi
196 schema:givenName G.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155437104.54
198 rdf:type schema:Person
199 sg:person.01241444010.35 schema:affiliation https://www.grid.ac/institutes/grid.7563.7
200 schema:familyName Lamorte
201 schema:givenName G.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241444010.35
203 rdf:type schema:Person
204 sg:person.01370304457.69 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
205 schema:familyName Olivi
206 schema:givenName A.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370304457.69
208 rdf:type schema:Person
209 sg:person.014676111567.21 schema:affiliation https://www.grid.ac/institutes/grid.7563.7
210 schema:familyName Piccirillo
211 schema:givenName S. G. M.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014676111567.21
213 rdf:type schema:Person
214 sg:person.0612774233.53 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
215 schema:familyName Reynolds
216 schema:givenName B. A.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612774233.53
218 rdf:type schema:Person
219 sg:person.0656152606.56 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
220 schema:familyName Dimeco
221 schema:givenName F.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656152606.56
223 rdf:type schema:Person
224 sg:person.0656171054.01 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
225 schema:familyName Brem
226 schema:givenName H.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656171054.01
228 rdf:type schema:Person
229 sg:person.0746514710.09 schema:affiliation https://www.grid.ac/institutes/grid.7563.7
230 schema:familyName Zanetti
231 schema:givenName N.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746514710.09
233 rdf:type schema:Person
234 sg:pub.10.1038/35102167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021100179
235 https://doi.org/10.1038/35102167
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/367645a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028822583
238 https://doi.org/10.1038/367645a0
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nature03128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027226854
241 https://doi.org/10.1038/nature03128
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nm904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037193002
244 https://doi.org/10.1038/nm904
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nmeth758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037605769
247 https://doi.org/10.1038/nmeth758
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nrc1232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009107668
250 https://doi.org/10.1038/nrc1232
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nrc1590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050924893
253 https://doi.org/10.1038/nrc1590
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nrc1889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035138833
256 https://doi.org/10.1038/nrc1889
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/sj.onc.1208925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029990219
259 https://doi.org/10.1038/sj.onc.1208925
260 rdf:type schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1078267826 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1083103523 schema:CreativeWork
263 https://doi.org/10.1002/(sici)1097-4547(19990501)56:3<248::aid-jnr4>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1045765316
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/1097-0215(20000520)89:3<251::aid-ijc7>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000682292
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/glia.10094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030472330
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1006/dbio.1996.0090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014800916
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1006/exnr.1998.6998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018588470
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.ccr.2005.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049812195
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.critrevonc.2004.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014822447
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0092-8674(00)81112-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041353219
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0896-6273(00)00148-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046424399
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0959-437x(02)00329-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047397188
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.0530291100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018724794
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.2036535100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012172628
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1080/08977190412331279890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039553454
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1083/jcb.200211021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040597604
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1097/00006123-199804000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060247414
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1158/0008-5472.can-04-1364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040457475
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1210/er.2002-0023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010343286
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1523/jneurosci.16-23-07599.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082999399
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1523/jneurosci.18-21-08853.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083335765
300 rdf:type schema:CreativeWork
301 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
302 schema:name Laboratory for Neural Stem Cell Biology, Queensland Brain Institute, University of Queensland, 4072 Brisbane, Queensland, Australia
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
305 schema:name Department of Neurosurgery, John Hopkins University, Baltimore, 21287 Maryland, USA
306 National Neurological Institute ‘C. Besta’, 20133 Milan, Italy
307 rdf:type schema:Organization
308 https://www.grid.ac/institutes/grid.417894.7 schema:alternateName Istituto Neurologico Carlo Besta
309 schema:name National Neurological Institute ‘C. Besta’, 20133 Milan, Italy
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.7563.7 schema:alternateName University of Milano-Bicocca
312 schema:name Department of Biotechnology and Biosciences, University of Milan–Bicocca, 20126 Milan, Italy
313 Stem Cell Research Institute, H. S. Raffaele, 20132 Milan, Italy
314 Unit of Cancer Stem Cell Biology, StemGen Spa, University of Milan–Bicocca, 20126 Milan, Italy
315 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...