Analysis of one million base pairs of Neanderthal DNA View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-11

AUTHORS

Richard E. Green, Johannes Krause, Susan E. Ptak, Adrian W. Briggs, Michael T. Ronan, Jan F. Simons, Lei Du, Michael Egholm, Jonathan M. Rothberg, Maja Paunovic, Svante Pääbo

ABSTRACT

Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes specific to anatomically fully modern humans. We have identified a 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA. Direct high-throughput sequencing of a DNA extract from this fossil has thus far yielded over one million base pairs of hominoid nuclear DNA sequences. Comparison with the human and chimpanzee genomes reveals that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago. Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort. More... »

PAGES

330

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05336

DOI

http://dx.doi.org/10.1038/nature05336

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022286131

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17108958


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