Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-12

AUTHORS

John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J. Watts, Christopher Callahan, Ian Kasman, Mallika Singh, May Chien, Christine Tan, Jo-Anne S. Hongo, Fred de Sauvage, Greg Plowman, Minhong Yan

ABSTRACT

Blood lineVEGF, or vascular endothelial growth factor, is the best-characterized inducer of tumour angiogenesis, and the blockade of VEGF has become an important tool in cancer therapy. But VEGF blockade is not effective against all tumours, so the search for alternative approaches continues. Two groups this week report that one such alternative could be blockade of Dll4, Delta-like ligand 4. This transmembrane molecule is part of the Notch signalling pathway. It was known to be essential for normal development of blood vessels in the embryo: the new work shows that it is also required for tumour angiogenesis. It may be a viable — and potentially well tolerated — alternative in patients with solid tumours that are resistant to anti-VEGF therapy. More... »

PAGES

1083-1087

Journal

TITLE

Nature

ISSUE

7122

VOLUME

444

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature05313

    DOI

    http://dx.doi.org/10.1038/nature05313

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034553835

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17183323


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