Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10

AUTHORS

Michael T. Lin, M. Flint Beal

ABSTRACT

Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the greatest risk factor for neurodegenerative diseases. In all major examples of these diseases there is strong evidence that mitochondrial dysfunction occurs early and acts causally in disease pathogenesis. Moreover, an impressive number of disease-specific proteins interact with mitochondria. Thus, therapies targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria, hold great promise. More... »

PAGES

787-795

References to SciGraph publications

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  • Journal

    TITLE

    Nature

    ISSUE

    7113

    VOLUME

    443

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature05292

    DOI

    http://dx.doi.org/10.1038/nature05292

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003167107

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17051205


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