Bidirectional control of CNS capillary diameter by pericytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-10-01

AUTHORS

Claire M. Peppiatt, Clare Howarth, Peter Mobbs, David Attwell

ABSTRACT

Brain imaging: seeing redNon-invasive imaging techniques that reveal those parts of the brain that are active by detecting the increased blood flow that supplies extra glucose and oxygen to active nerve cells. Until now it was assumed that blood flow is controlled by the contraction of smooth muscle around large blood vessels called arterioles. Now an additional level of blood flow control has been discovered, downstream of arterioles. This control is exerted by the pericytes, small cells that wrap around the capillaries close to active nerve cells. The pericytes, that act by squeezing the capillary to reduce blood flow though it, are likely to contribute to the signals detected in brain imaging techniques, and could also provide a target for therapy in disorders of brain blood flow. More... »

PAGES

700-704

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05193

DOI

http://dx.doi.org/10.1038/nature05193

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027759728

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17036005


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