Ontology type: schema:ScholarlyArticle Open Access: True
2006-11
AUTHORSR. E. MacLaren, R. A. Pearson, A. MacNeil, R. H. Douglas, T. E. Salt, M. Akimoto, A. Swaroop, J. C. Sowden, R. R. Ali
ABSTRACTRetinal repairPhotoreceptor loss results in irreversible blindness in many retinal diseases. Attempts to repair the damage by implanting brain or retinal stem cells into adult retina have largely failed, with no new photoreceptors produced and few signs that transplanted cells connect with retinal neurons or restore vision. Now, an experiment in mice shows that adult retina can incorporate new photoreceptor cells, provided the transplanted cells are committed rod precursors at a certain stage of development, defined by expression of transcription factor Nrl (tagged green in the cell in the centre of the cover; rhodopsin, the rod photopigment, is shown red). The study could pave the way for the generation of cells suitable for transplantation from either embryonic or adult-derived stem cells. The findings also challenge the common assumption that undifferentiated stem cells offer the best prospect for CNS repair. More... »
PAGES203-207
http://scigraph.springernature.com/pub.10.1038/nature05161
DOIhttp://dx.doi.org/10.1038/nature05161
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1012612321
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17093405
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Ophthalmology and Optometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Differentiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Proliferation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell- and Tissue-Based Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chickens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Light",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Photoreceptor Cells, Vertebrate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retina",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retinal Degeneration",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Synapses",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Time Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Vitreoretinal Service, Moorfields Eye Hospital, 162 City Road, EC1V 2PD, London, UK",
"id": "http://www.grid.ac/institutes/grid.439257.e",
"name": [
"Division of Molecular Therapy, University College London Institute of Ophthalmology, 11\u201343 Bath Street, EC1V 9EL, London, UK",
"Vitreoretinal Service, Moorfields Eye Hospital, 162 City Road, EC1V 2PD, London, UK"
],
"type": "Organization"
},
"familyName": "MacLaren",
"givenName": "R. E.",
"id": "sg:person.0761624765.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761624765.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Developmental Biology Unit, University College London Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Developmental Biology Unit, University College London Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK"
],
"type": "Organization"
},
"familyName": "Pearson",
"givenName": "R. A.",
"id": "sg:person.011266017417.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011266017417.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Molecular Therapy, University College London Institute of Ophthalmology, 11\u201343 Bath Street, EC1V 9EL, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Division of Molecular Therapy, University College London Institute of Ophthalmology, 11\u201343 Bath Street, EC1V 9EL, London, UK"
],
"type": "Organization"
},
"familyName": "MacNeil",
"givenName": "A.",
"id": "sg:person.01322364025.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322364025.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Henry Wellcome Laboratory for Vision Sciences, Department of Optometry and Visual Science, City University, Northampton Square, EC1V 0HB, London, UK",
"id": "http://www.grid.ac/institutes/grid.28577.3f",
"name": [
"Henry Wellcome Laboratory for Vision Sciences, Department of Optometry and Visual Science, City University, Northampton Square, EC1V 0HB, London, UK"
],
"type": "Organization"
},
"familyName": "Douglas",
"givenName": "R. H.",
"id": "sg:person.01237571270.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237571270.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Visual Science, University College London Institute of Ophthalmology, 11-43 Bath Street, EC1V 9EL, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Division of Visual Science, University College London Institute of Ophthalmology, 11-43 Bath Street, EC1V 9EL, London, UK"
],
"type": "Organization"
},
"familyName": "Salt",
"givenName": "T. E.",
"id": "sg:person.01157266476.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157266476.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Translational Research Center, Kyoto University Hospital, 606-8507, Sakyo-ku, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.411217.0",
"name": [
"Department of Ophthalmology and Visual Sciences",
"Translational Research Center, Kyoto University Hospital, 606-8507, Sakyo-ku, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Akimoto",
"givenName": "M.",
"id": "sg:person.01102166464.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102166464.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Human Genetics, University of Michigan, 48105, Ann Arbor, Michigan, USA",
"id": "http://www.grid.ac/institutes/grid.214458.e",
"name": [
"Department of Ophthalmology and Visual Sciences",
"Department of Human Genetics, University of Michigan, 48105, Ann Arbor, Michigan, USA"
],
"type": "Organization"
},
"familyName": "Swaroop",
"givenName": "A.",
"id": "sg:person.01060424730.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060424730.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Developmental Biology Unit, University College London Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Developmental Biology Unit, University College London Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK"
],
"type": "Organization"
},
"familyName": "Sowden",
"givenName": "J. C.",
"id": "sg:person.0606075606.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606075606.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Molecular Immunology Unit, University College London Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Division of Molecular Therapy, University College London Institute of Ophthalmology, 11\u201343 Bath Street, EC1V 9EL, London, UK",
"Molecular Immunology Unit, University College London Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK"
],
"type": "Organization"
},
"familyName": "Ali",
"givenName": "R. R.",
"id": "sg:person.01306634725.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306634725.94"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/ncb1053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053515029",
"https://doi.org/10.1038/ncb1053"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng774",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031563734",
"https://doi.org/10.1038/ng774"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/88443",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024154404",
"https://doi.org/10.1038/88443"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0297-216",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013571435",
"https://doi.org/10.1038/ng0297-216"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature729",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050743069",
"https://doi.org/10.1038/nature729"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0393-213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044396422",
"https://doi.org/10.1038/ng0393-213"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302571",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049999819",
"https://doi.org/10.1038/sj.gt.3302571"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature730",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017087327",
"https://doi.org/10.1038/nature730"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0693-130",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046245408",
"https://doi.org/10.1038/ng0693-130"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0692-209",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018852505",
"https://doi.org/10.1038/ng0692-209"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1472-6750-2-11",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031642554",
"https://doi.org/10.1186/1472-6750-2-11"
],
"type": "CreativeWork"
}
],
"datePublished": "2006-11",
"datePublishedReg": "2006-11-01",
"description": "Retinal repairPhotoreceptor loss results in irreversible blindness in many retinal diseases. Attempts to repair the damage by implanting brain or retinal stem cells into adult retina have largely failed, with no new photoreceptors produced and few signs that transplanted cells connect with retinal neurons or restore vision. Now, an experiment in mice shows that adult retina can incorporate new photoreceptor cells, provided the transplanted cells are committed rod precursors at a certain stage of development, defined by expression of transcription factor Nrl (tagged green in the cell in the centre of the cover; rhodopsin, the rod photopigment, is shown red). The study could pave the way for the generation of cells suitable for transplantation from either embryonic or adult-derived stem cells. The findings also challenge the common assumption that undifferentiated stem cells offer the best prospect for CNS repair.",
"genre": "article",
"id": "sg:pub.10.1038/nature05161",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2771124",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7116",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "444"
}
],
"keywords": [
"adult retina",
"stem cells",
"adult-derived stem cells",
"retinal stem cells",
"retinal neurons",
"irreversible blindness",
"CNS repair",
"mice show",
"retinal repair",
"retinal diseases",
"rod precursors",
"photoreceptor precursors",
"photoreceptor cells",
"generation of cells",
"transplantation",
"transcription factor NRL",
"retina",
"cells",
"repair",
"new photoreceptors",
"loss results",
"disease",
"neurons",
"brain",
"blindness",
"signs",
"photoreceptors",
"expression",
"findings",
"damage",
"certain stages",
"study",
"NRL",
"stage",
"development",
"precursors",
"vision",
"results",
"attempt",
"good prospects",
"generation",
"show",
"experiments",
"way",
"prospects",
"common assumption",
"assumption"
],
"name": "Retinal repair by transplantation of photoreceptor precursors",
"pagination": "203-207",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1012612321"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nature05161"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"17093405"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nature05161",
"https://app.dimensions.ai/details/publication/pub.1012612321"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_422.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/nature05161"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature05161'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature05161'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature05161'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature05161'
This table displays all metadata directly associated to this object as RDF triples.
291 TRIPLES
21 PREDICATES
99 URIs
79 LITERALS
21 BLANK NODES