Retinal repair by transplantation of photoreceptor precursors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-11

AUTHORS

R. E. MacLaren, R. A. Pearson, A. MacNeil, R. H. Douglas, T. E. Salt, M. Akimoto, A. Swaroop, J. C. Sowden, R. R. Ali

ABSTRACT

Retinal repairPhotoreceptor loss results in irreversible blindness in many retinal diseases. Attempts to repair the damage by implanting brain or retinal stem cells into adult retina have largely failed, with no new photoreceptors produced and few signs that transplanted cells connect with retinal neurons or restore vision. Now, an experiment in mice shows that adult retina can incorporate new photoreceptor cells, provided the transplanted cells are committed rod precursors at a certain stage of development, defined by expression of transcription factor Nrl (tagged green in the cell in the centre of the cover; rhodopsin, the rod photopigment, is shown red). The study could pave the way for the generation of cells suitable for transplantation from either embryonic or adult-derived stem cells. The findings also challenge the common assumption that undifferentiated stem cells offer the best prospect for CNS repair. More... »

PAGES

203-207

Journal

TITLE

Nature

ISSUE

7116

VOLUME

444

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature05161

DOI

http://dx.doi.org/10.1038/nature05161

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012612321

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17093405


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