The stem-cell niche as an entity of action View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06

AUTHORS

David T Scadden

ABSTRACT

Stem-cell populations are established in 'niches'--specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics. More... »

PAGES

1075-1079

References to SciGraph publications

  • 2004-04. Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries in NATURE
  • 2005-10. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2004-01. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis in NATURE MEDICINE
  • 1998-06. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development in NATURE
  • 2005-06. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment in NATURE
  • 2004-10. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells in NATURE
  • 2003-10. Osteoblastic cells regulate the haematopoietic stem cell niche in NATURE
  • 2005-12. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche in NATURE
  • 2003-06. Endothelial signaling during development in NATURE MEDICINE
  • 2006-01. The adult Drosophila posterior midgut is maintained by pluripotent stem cells in NATURE
  • 2000-10. Somatic support cells restrict germline stem cell self-renewal and promote differentiation in NATURE
  • 2003-10. Identification of the haematopoietic stem cell niche and control of the niche size in NATURE
  • 2002-06. A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans in NATURE
  • 2006-01. Evidence that stem cells reside in the adult Drosophila midgut epithelium in NATURE
  • 2006-02. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor in NATURE
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature04957

    DOI

    http://dx.doi.org/10.1038/nature04957

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047165782

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16810242


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Extracellular Matrix", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organ Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Paracrine Communication", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stem Cells", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Massachusetts General Hospital Center for Regenerative Medicine, Harvard Stem Cell Institute, 185 Cambridge Street, CPZN - 4265A, Boston, Massachusetts 02114, USA. scadden.david@mgh.harvard.edu"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Scadden", 
            "givenName": "David T", 
            "id": "sg:person.0623550515.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623550515.44"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.cub.2003.09.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000108135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2003.09.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000108135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001795574", 
              "https://doi.org/10.1038/nature04186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001795574", 
              "https://doi.org/10.1038/nature04186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001795574", 
              "https://doi.org/10.1038/nature04186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003509222", 
              "https://doi.org/10.1038/nature02040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003509222", 
              "https://doi.org/10.1038/nature02040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003673253", 
              "https://doi.org/10.1038/nature04247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003673253", 
              "https://doi.org/10.1038/nature04247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003673253", 
              "https://doi.org/10.1038/nature04247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004880751", 
              "https://doi.org/10.1038/nature754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004880751", 
              "https://doi.org/10.1038/nature754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1359/jbmr.2003.18.4.696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007766542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2003-05-1670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010957726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1066707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015771633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)01015-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018479938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2006.01.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018918382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018965374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.10.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020452147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci3687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022392264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35037606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023189909", 
              "https://doi.org/10.1038/35037606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35037606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023189909", 
              "https://doi.org/10.1038/35037606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023297592", 
              "https://doi.org/10.1038/nature04371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023297592", 
              "https://doi.org/10.1038/nature04371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023297592", 
              "https://doi.org/10.1038/nature04371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.290.5490.328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023854286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2005.11.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025029942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1095505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028543094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/367645a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028822583", 
              "https://doi.org/10.1038/367645a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030063626", 
              "https://doi.org/10.1038/nm973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030063626", 
              "https://doi.org/10.1038/nm973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.0022-202x.2005.23867.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030241689", 
              "https://doi.org/10.1111/j.0022-202x.2005.23867.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0022-202x.2005.23867.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030241689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81631-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030262329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.06.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030497356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0012-1606(02)00042-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030607042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90251-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031600813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2004.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032285616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2005.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032474525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033616640", 
              "https://doi.org/10.1038/nature02041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033616640", 
              "https://doi.org/10.1038/nature02041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033678207", 
              "https://doi.org/10.1038/nature03703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033678207", 
              "https://doi.org/10.1038/nature03703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033678207", 
              "https://doi.org/10.1038/nature03703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035521246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81424-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036298330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20041992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039569649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20041992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039569649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2005.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040554418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(98)70443-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040871812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041064292", 
              "https://doi.org/10.1038/nature04333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041064292", 
              "https://doi.org/10.1038/nature04333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041064292", 
              "https://doi.org/10.1038/nature04333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(01)00197-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042424216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045430171", 
              "https://doi.org/10.1038/nm0603-661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045430171", 
              "https://doi.org/10.1038/nm0603-661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.16.9448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045854586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.16.9448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045854586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046218320", 
              "https://doi.org/10.1038/nature02989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046218320", 
              "https://doi.org/10.1038/nature02989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1066700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046696646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047142294", 
              "https://doi.org/10.1038/nature02436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047142294", 
              "https://doi.org/10.1038/nature02436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047142294", 
              "https://doi.org/10.1038/nature02436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.21.012704.131525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047691540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.21.012704.131525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047691540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.05.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048721879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/31269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048977106", 
              "https://doi.org/10.1038/31269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/31269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048977106", 
              "https://doi.org/10.1038/31269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-01-0272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049178589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0830856100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050123365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1096-9861(20001002)425:4<479::aid-cne2>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051325756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052550697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-11-4422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053664748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.287.5454.860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062568255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074366670", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082377481", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082882524", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083265269", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083296920", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2006-06", 
        "datePublishedReg": "2006-06-01", 
        "description": "Stem-cell populations are established in 'niches'--specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature04957", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7097", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "441"
          }
        ], 
        "name": "The stem-cell niche as an entity of action", 
        "pagination": "1075-1079", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e0ae713430d12bdcf93b8923e9118d6b23d9a4cb066f9a49b2268a7cebe277e9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16810242"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature04957"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1047165782"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature04957", 
          "https://app.dimensions.ai/details/publication/pub.1047165782"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000365_0000000365/records_71674_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nature04957"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature04957'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature04957'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature04957'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature04957'


     

    This table displays all metadata directly associated to this object as RDF triples.

    280 TRIPLES      21 PREDICATES      93 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature04957 schema:about N2d1909a6b90648e08dea604c244b4803
    2 N55953a23187c4dfdb7062b0a5b62c2b2
    3 N751018414d5148e3b5b140dd2e0224eb
    4 N921bb645cc924a85a8e0a41f41d10db3
    5 Naadccbeaa2b84185a2af468350807593
    6 Nc012ab5310574f619f177423c9b2e314
    7 Ne5882b014aaa48199cd26aeda27e1b12
    8 Nee950e41bcde4a6a9eada4a827becf14
    9 anzsrc-for:06
    10 anzsrc-for:0601
    11 schema:author Na40506818990496b87619b904cfb39a4
    12 schema:citation sg:pub.10.1038/31269
    13 sg:pub.10.1038/35037606
    14 sg:pub.10.1038/367645a0
    15 sg:pub.10.1038/nature02040
    16 sg:pub.10.1038/nature02041
    17 sg:pub.10.1038/nature02436
    18 sg:pub.10.1038/nature02989
    19 sg:pub.10.1038/nature03703
    20 sg:pub.10.1038/nature04186
    21 sg:pub.10.1038/nature04247
    22 sg:pub.10.1038/nature04333
    23 sg:pub.10.1038/nature04371
    24 sg:pub.10.1038/nature754
    25 sg:pub.10.1038/nm0603-661
    26 sg:pub.10.1038/nm973
    27 sg:pub.10.1111/j.0022-202x.2005.23867.x
    28 https://app.dimensions.ai/details/publication/pub.1074366670
    29 https://app.dimensions.ai/details/publication/pub.1082377481
    30 https://app.dimensions.ai/details/publication/pub.1082882524
    31 https://app.dimensions.ai/details/publication/pub.1083265269
    32 https://app.dimensions.ai/details/publication/pub.1083296920
    33 https://doi.org/10.1002/1096-9861(20001002)425:4<479::aid-cne2>3.0.co;2-3
    34 https://doi.org/10.1016/0092-8674(93)90251-k
    35 https://doi.org/10.1016/j.ceb.2004.09.003
    36 https://doi.org/10.1016/j.cell.2005.05.026
    37 https://doi.org/10.1016/j.cell.2005.06.031
    38 https://doi.org/10.1016/j.cell.2005.10.041
    39 https://doi.org/10.1016/j.cub.2003.09.033
    40 https://doi.org/10.1016/j.devcel.2005.11.003
    41 https://doi.org/10.1016/j.devcel.2006.01.015
    42 https://doi.org/10.1016/j.exphem.2005.02.004
    43 https://doi.org/10.1016/j.tcb.2005.12.005
    44 https://doi.org/10.1016/s0012-1606(02)00042-8
    45 https://doi.org/10.1016/s0092-8674(00)81424-5
    46 https://doi.org/10.1016/s0092-8674(00)81631-1
    47 https://doi.org/10.1016/s0092-8674(02)01015-2
    48 https://doi.org/10.1016/s0960-9822(98)70443-9
    49 https://doi.org/10.1016/s1097-2765(01)00197-6
    50 https://doi.org/10.1073/pnas.0830856100
    51 https://doi.org/10.1073/pnas.95.16.9448
    52 https://doi.org/10.1084/jem.20041992
    53 https://doi.org/10.1111/j.0022-202x.2005.23867.x
    54 https://doi.org/10.1126/science.1066700
    55 https://doi.org/10.1126/science.1066707
    56 https://doi.org/10.1126/science.1095505
    57 https://doi.org/10.1126/science.287.5454.860
    58 https://doi.org/10.1126/science.290.5490.328
    59 https://doi.org/10.1146/annurev.cellbio.21.012704.131525
    60 https://doi.org/10.1172/jci3687
    61 https://doi.org/10.1182/blood-2003-05-1670
    62 https://doi.org/10.1182/blood-2004-01-0272
    63 https://doi.org/10.1182/blood-2004-11-4422
    64 https://doi.org/10.1242/dev.01026
    65 https://doi.org/10.1242/dev.01202
    66 https://doi.org/10.1242/dev.01576
    67 https://doi.org/10.1359/jbmr.2003.18.4.696
    68 schema:datePublished 2006-06
    69 schema:datePublishedReg 2006-06-01
    70 schema:description Stem-cell populations are established in 'niches'--specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics.
    71 schema:genre research_article
    72 schema:inLanguage en
    73 schema:isAccessibleForFree false
    74 schema:isPartOf N526ee15d855642559e2cb9f1c7bde9cd
    75 Nbaa1f120d49f4b12b57a120841a6ff28
    76 sg:journal.1018957
    77 schema:name The stem-cell niche as an entity of action
    78 schema:pagination 1075-1079
    79 schema:productId N0f1de765dd4d4b259ea5ef5441c792c8
    80 N1cfa2644150b474493eb934b01e6d1be
    81 N328ce782e5864085a9c761980f6986e1
    82 N76733ad6cb53451ab0a1fc0e2020cb82
    83 N99b62f8907dd4527ba7ae917af53bd66
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047165782
    85 https://doi.org/10.1038/nature04957
    86 schema:sdDatePublished 2019-04-11T12:57
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher Nfa5f961e8c2547ce8a882787bf4fc933
    89 schema:url http://www.nature.com/articles/nature04957
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N0f1de765dd4d4b259ea5ef5441c792c8 schema:name nlm_unique_id
    94 schema:value 0410462
    95 rdf:type schema:PropertyValue
    96 N1cfa2644150b474493eb934b01e6d1be schema:name readcube_id
    97 schema:value e0ae713430d12bdcf93b8923e9118d6b23d9a4cb066f9a49b2268a7cebe277e9
    98 rdf:type schema:PropertyValue
    99 N2d1909a6b90648e08dea604c244b4803 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Extracellular Matrix
    101 rdf:type schema:DefinedTerm
    102 N328ce782e5864085a9c761980f6986e1 schema:name dimensions_id
    103 schema:value pub.1047165782
    104 rdf:type schema:PropertyValue
    105 N526ee15d855642559e2cb9f1c7bde9cd schema:volumeNumber 441
    106 rdf:type schema:PublicationVolume
    107 N55953a23187c4dfdb7062b0a5b62c2b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Organ Specificity
    109 rdf:type schema:DefinedTerm
    110 N751018414d5148e3b5b140dd2e0224eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Humans
    112 rdf:type schema:DefinedTerm
    113 N76733ad6cb53451ab0a1fc0e2020cb82 schema:name pubmed_id
    114 schema:value 16810242
    115 rdf:type schema:PropertyValue
    116 N921bb645cc924a85a8e0a41f41d10db3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Neoplasms
    118 rdf:type schema:DefinedTerm
    119 N99b62f8907dd4527ba7ae917af53bd66 schema:name doi
    120 schema:value 10.1038/nature04957
    121 rdf:type schema:PropertyValue
    122 Na40506818990496b87619b904cfb39a4 rdf:first sg:person.0623550515.44
    123 rdf:rest rdf:nil
    124 Naadccbeaa2b84185a2af468350807593 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Paracrine Communication
    126 rdf:type schema:DefinedTerm
    127 Nbaa1f120d49f4b12b57a120841a6ff28 schema:issueNumber 7097
    128 rdf:type schema:PublicationIssue
    129 Nc012ab5310574f619f177423c9b2e314 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Stem Cells
    131 rdf:type schema:DefinedTerm
    132 Ne5882b014aaa48199cd26aeda27e1b12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Cell Differentiation
    134 rdf:type schema:DefinedTerm
    135 Nee950e41bcde4a6a9eada4a827becf14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Animals
    137 rdf:type schema:DefinedTerm
    138 Nfa5f961e8c2547ce8a882787bf4fc933 schema:name Springer Nature - SN SciGraph project
    139 rdf:type schema:Organization
    140 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    141 schema:name Biological Sciences
    142 rdf:type schema:DefinedTerm
    143 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    144 schema:name Biochemistry and Cell Biology
    145 rdf:type schema:DefinedTerm
    146 sg:journal.1018957 schema:issn 0090-0028
    147 1476-4687
    148 schema:name Nature
    149 rdf:type schema:Periodical
    150 sg:person.0623550515.44 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    151 schema:familyName Scadden
    152 schema:givenName David T
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623550515.44
    154 rdf:type schema:Person
    155 sg:pub.10.1038/31269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048977106
    156 https://doi.org/10.1038/31269
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1038/35037606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023189909
    159 https://doi.org/10.1038/35037606
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1038/367645a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028822583
    162 https://doi.org/10.1038/367645a0
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1038/nature02040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003509222
    165 https://doi.org/10.1038/nature02040
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1038/nature02041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033616640
    168 https://doi.org/10.1038/nature02041
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1038/nature02436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047142294
    171 https://doi.org/10.1038/nature02436
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1038/nature02989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046218320
    174 https://doi.org/10.1038/nature02989
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1038/nature03703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033678207
    177 https://doi.org/10.1038/nature03703
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1038/nature04186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001795574
    180 https://doi.org/10.1038/nature04186
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1038/nature04247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003673253
    183 https://doi.org/10.1038/nature04247
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1038/nature04333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041064292
    186 https://doi.org/10.1038/nature04333
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/nature04371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023297592
    189 https://doi.org/10.1038/nature04371
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/nature754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004880751
    192 https://doi.org/10.1038/nature754
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/nm0603-661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045430171
    195 https://doi.org/10.1038/nm0603-661
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/nm973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030063626
    198 https://doi.org/10.1038/nm973
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1111/j.0022-202x.2005.23867.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030241689
    201 https://doi.org/10.1111/j.0022-202x.2005.23867.x
    202 rdf:type schema:CreativeWork
    203 https://app.dimensions.ai/details/publication/pub.1074366670 schema:CreativeWork
    204 https://app.dimensions.ai/details/publication/pub.1082377481 schema:CreativeWork
    205 https://app.dimensions.ai/details/publication/pub.1082882524 schema:CreativeWork
    206 https://app.dimensions.ai/details/publication/pub.1083265269 schema:CreativeWork
    207 https://app.dimensions.ai/details/publication/pub.1083296920 schema:CreativeWork
    208 https://doi.org/10.1002/1096-9861(20001002)425:4<479::aid-cne2>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051325756
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/0092-8674(93)90251-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1031600813
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.ceb.2004.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032285616
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/j.cell.2005.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048721879
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/j.cell.2005.06.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030497356
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/j.cell.2005.10.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020452147
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/j.cub.2003.09.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000108135
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/j.devcel.2005.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025029942
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/j.devcel.2006.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018918382
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/j.exphem.2005.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032474525
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/j.tcb.2005.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040554418
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/s0012-1606(02)00042-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030607042
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1016/s0092-8674(00)81424-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036298330
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/s0092-8674(00)81631-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030262329
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/s0092-8674(02)01015-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018479938
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/s0960-9822(98)70443-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040871812
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/s1097-2765(01)00197-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042424216
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1073/pnas.0830856100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050123365
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1073/pnas.95.16.9448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045854586
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1084/jem.20041992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039569649
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1111/j.0022-202x.2005.23867.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030241689
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1126/science.1066700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046696646
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1126/science.1066707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015771633
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1126/science.1095505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028543094
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1126/science.287.5454.860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568255
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1126/science.290.5490.328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023854286
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1146/annurev.cellbio.21.012704.131525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047691540
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1172/jci3687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022392264
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1182/blood-2003-05-1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010957726
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1182/blood-2004-01-0272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049178589
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1182/blood-2004-11-4422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053664748
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1242/dev.01026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018965374
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1242/dev.01202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052550697
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1242/dev.01576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035521246
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1359/jbmr.2003.18.4.696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007766542
    277 rdf:type schema:CreativeWork
    278 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    279 schema:name Massachusetts General Hospital Center for Regenerative Medicine, Harvard Stem Cell Institute, 185 Cambridge Street, CPZN - 4265A, Boston, Massachusetts 02114, USA. scadden.david@mgh.harvard.edu
    280 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...