Transforming growth factor-β induces development of the TH17 lineage View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05

AUTHORS

Paul R Mangan, Laurie E Harrington, Darrell B O'Quinn, Whitney S Helms, Daniel C Bullard, Charles O Elson, Robin D Hatton, Sharon M Wahl, Trenton R Schoeb, Casey T Weaver

ABSTRACT

A new lineage of effector CD4+ T cells characterized by production of interleukin (IL)-17, the T-helper-17 (T(H)17) lineage, was recently described based on developmental and functional features distinct from those of classical T(H)1 and T(H)2 lineages. Like T(H)1 and T(H)2, T(H)17 cells almost certainly evolved to provide adaptive immunity tailored to specific classes of pathogens, such as extracellular bacteria. Aberrant T(H)17 responses have been implicated in a growing list of autoimmune disorders. T(H)17 development has been linked to IL-23, an IL-12 cytokine family member that shares with IL-12 a common subunit, IL-12p40 (ref. 8). The IL-23 and IL-12 receptors also share a subunit, IL-12Rbeta1, that pairs with unique, inducible components, IL-23R and IL-12Rbeta2, to confer receptor responsiveness. Here we identify transforming growth factor-beta (TGF-beta) as a cytokine critical for commitment to T(H)17 development. TGF-beta acts to upregulate IL-23R expression, thereby conferring responsiveness to IL-23. Although dispensable for the development of IL-17-producing T cells in vitro and in vivo, IL-23 is required for host protection against a bacterial pathogen, Citrobacter rodentium. The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages. More... »

PAGES

231-234

Journal

TITLE

Nature

ISSUE

7090

VOLUME

441

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature04754

DOI

http://dx.doi.org/10.1038/nature04754

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043278106

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16648837


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Lineage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Forkhead Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-17", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-23", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-23 Subunit p19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th1 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th2 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-2170, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mangan", 
        "givenName": "Paul R", 
        "id": "sg:person.01101426743.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101426743.93"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Harrington", 
        "givenName": "Laurie E", 
        "id": "sg:person.0616302042.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616302042.39"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "O'Quinn", 
        "givenName": "Darrell B", 
        "id": "sg:person.01323502700.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323502700.54"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Helms", 
        "givenName": "Whitney S", 
        "id": "sg:person.01234254420.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234254420.48"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bullard", 
        "givenName": "Daniel C", 
        "id": "sg:person.014333621177.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014333621177.38"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Elson", 
        "givenName": "Charles O", 
        "id": "sg:person.0626706150.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626706150.86"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hatton", 
        "givenName": "Robin D", 
        "id": "sg:person.0724334003.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724334003.08"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wahl", 
        "givenName": "Sharon M", 
        "id": "sg:person.01076747244.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076747244.03"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Schoeb", 
        "givenName": "Trenton R", 
        "id": "sg:person.010451630337.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010451630337.50"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Weaver", 
        "givenName": "Casey T", 
        "id": "sg:person.01031057040.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031057040.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature01355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001374380", 
          "https://doi.org/10.1038/nature01355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2006.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009201806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.173.12.7249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012301348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013395893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359693a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015092130", 
          "https://doi.org/10.1038/359693a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.172.1.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016479186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.71.9.5077-5086.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017823378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018494364", 
          "https://doi.org/10.1038/nri954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018494364", 
          "https://doi.org/10.1038/nri954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.2.770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022493939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)00070-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023691475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030750872", 
          "https://doi.org/10.1038/ni1261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030750872", 
          "https://doi.org/10.1038/ni1261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.183.6.2669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033436331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035188143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.2001889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036910558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.11.5699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037908336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0105-2896.2004.00208.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040625620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.24.021605.090737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043617931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.24.021605.090737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043617931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.72.6.3315-3324.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044149152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0501701102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046921863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048335036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1078/1438-4221-00247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048804774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051485127", 
          "https://doi.org/10.1038/ni1254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051485127", 
          "https://doi.org/10.1038/ni1254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20050193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052433146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20050193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052433146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053117793", 
          "https://doi.org/10.1038/ni1197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053117793", 
          "https://doi.org/10.1038/ni1197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074462292", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.174.10.5950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077049003"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-05", 
    "datePublishedReg": "2006-05-01", 
    "description": "A new lineage of effector CD4+ T cells characterized by production of interleukin (IL)-17, the T-helper-17 (T(H)17) lineage, was recently described based on developmental and functional features distinct from those of classical T(H)1 and T(H)2 lineages. Like T(H)1 and T(H)2, T(H)17 cells almost certainly evolved to provide adaptive immunity tailored to specific classes of pathogens, such as extracellular bacteria. Aberrant T(H)17 responses have been implicated in a growing list of autoimmune disorders. T(H)17 development has been linked to IL-23, an IL-12 cytokine family member that shares with IL-12 a common subunit, IL-12p40 (ref. 8). The IL-23 and IL-12 receptors also share a subunit, IL-12Rbeta1, that pairs with unique, inducible components, IL-23R and IL-12Rbeta2, to confer receptor responsiveness. Here we identify transforming growth factor-beta (TGF-beta) as a cytokine critical for commitment to T(H)17 development. TGF-beta acts to upregulate IL-23R expression, thereby conferring responsiveness to IL-23. Although dispensable for the development of IL-17-producing T cells in vitro and in vivo, IL-23 is required for host protection against a bacterial pathogen, Citrobacter rodentium. The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature04754", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2681759", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2715533", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2724626", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7090", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "441"
      }
    ], 
    "name": "Transforming growth factor-\u03b2 induces development of the TH17 lineage", 
    "pagination": "231-234", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ce25f26642640660360a9300d5656516e548c33270cf15c28e0b31055ee7392f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16648837"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature04754"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043278106"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature04754", 
      "https://app.dimensions.ai/details/publication/pub.1043278106"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118312_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nature/journal/v441/n7090/full/nature04754.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature04754'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature04754'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature04754'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature04754'


 

This table displays all metadata directly associated to this object as RDF triples.

272 TRIPLES      21 PREDICATES      70 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature04754 schema:about N0442401275f046cbabf58d5ca1465721
2 N1139bcabf6a0477782e122abf00131e5
3 N15fe2b34c5f44a5bab174ea22f814afa
4 N18638d3faf0d4a169785b644fe1e9fa0
5 N1ad2007361234e998cff9f14342a4f13
6 N659e8e817038447e8529b3f6e44913d9
7 N74bebe8da29043b5855cdc3b16b03db0
8 N7e53d8b080894cee8400dbc1db897e6b
9 Na295c25d41f848f5bcd678dffdd1a810
10 Nac933aa14ef04a7d9142cf27b9c3bcae
11 Nb02c85097760425ea0753fe55a6bc8f1
12 Nc2745ce162fb4d82aa9ca88d78818fae
13 Ncf776c32b3534423a2728778aedf3372
14 Nf3e56f0699a247779e376cae512e4e56
15 Nfbc5a1826ee04711be15399da8fe6b83
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N6d2388dddebe46b8bf2762751a2642c0
19 schema:citation sg:pub.10.1038/359693a0
20 sg:pub.10.1038/nature01355
21 sg:pub.10.1038/ni1197
22 sg:pub.10.1038/ni1254
23 sg:pub.10.1038/ni1261
24 sg:pub.10.1038/nri954
25 https://app.dimensions.ai/details/publication/pub.1074462292
26 https://doi.org/10.1016/j.immuni.2006.01.001
27 https://doi.org/10.1016/s1074-7613(00)00070-4
28 https://doi.org/10.1073/pnas.0501701102
29 https://doi.org/10.1073/pnas.90.2.770
30 https://doi.org/10.1078/1438-4221-00247
31 https://doi.org/10.1084/jem.183.6.2669
32 https://doi.org/10.1084/jem.2001889
33 https://doi.org/10.1084/jem.20030152
34 https://doi.org/10.1084/jem.20030896
35 https://doi.org/10.1084/jem.20041257
36 https://doi.org/10.1084/jem.20050193
37 https://doi.org/10.1111/j.0105-2896.2004.00208.x
38 https://doi.org/10.1128/iai.71.9.5077-5086.2003
39 https://doi.org/10.1128/iai.72.6.3315-3324.2004
40 https://doi.org/10.1146/annurev.immunol.24.021605.090737
41 https://doi.org/10.4049/jimmunol.168.11.5699
42 https://doi.org/10.4049/jimmunol.172.1.433
43 https://doi.org/10.4049/jimmunol.173.12.7249
44 https://doi.org/10.4049/jimmunol.174.10.5950
45 schema:datePublished 2006-05
46 schema:datePublishedReg 2006-05-01
47 schema:description A new lineage of effector CD4+ T cells characterized by production of interleukin (IL)-17, the T-helper-17 (T(H)17) lineage, was recently described based on developmental and functional features distinct from those of classical T(H)1 and T(H)2 lineages. Like T(H)1 and T(H)2, T(H)17 cells almost certainly evolved to provide adaptive immunity tailored to specific classes of pathogens, such as extracellular bacteria. Aberrant T(H)17 responses have been implicated in a growing list of autoimmune disorders. T(H)17 development has been linked to IL-23, an IL-12 cytokine family member that shares with IL-12 a common subunit, IL-12p40 (ref. 8). The IL-23 and IL-12 receptors also share a subunit, IL-12Rbeta1, that pairs with unique, inducible components, IL-23R and IL-12Rbeta2, to confer receptor responsiveness. Here we identify transforming growth factor-beta (TGF-beta) as a cytokine critical for commitment to T(H)17 development. TGF-beta acts to upregulate IL-23R expression, thereby conferring responsiveness to IL-23. Although dispensable for the development of IL-17-producing T cells in vitro and in vivo, IL-23 is required for host protection against a bacterial pathogen, Citrobacter rodentium. The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf Ncd9ae5b96ddb4ecba0b1caa47c7b3492
52 Nd3f0fe80a7824c8aa744091d5085f2fb
53 sg:journal.1018957
54 schema:name Transforming growth factor-β induces development of the TH17 lineage
55 schema:pagination 231-234
56 schema:productId N666dc91c62be4405aaabf2021ebf511f
57 Nb2223245afa74bf089e1ec8bb94f716f
58 Nc5211474ef1648f491b0c66e24f37c54
59 Nd8911db090564e07bcf05270f367b9ce
60 Nf43efe14493040d7ab7d0a767f537730
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278106
62 https://doi.org/10.1038/nature04754
63 schema:sdDatePublished 2019-04-11T12:04
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nd80bfc686609496f8182946c735ff6cd
66 schema:url http://www.nature.com/nature/journal/v441/n7090/full/nature04754.html
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0442401275f046cbabf58d5ca1465721 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Cell Lineage
72 rdf:type schema:DefinedTerm
73 N1139bcabf6a0477782e122abf00131e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Transforming Growth Factor beta
75 rdf:type schema:DefinedTerm
76 N15fe2b34c5f44a5bab174ea22f814afa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Forkhead Transcription Factors
78 rdf:type schema:DefinedTerm
79 N18638d3faf0d4a169785b644fe1e9fa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Animals
81 rdf:type schema:DefinedTerm
82 N1ad2007361234e998cff9f14342a4f13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Interleukin-17
84 rdf:type schema:DefinedTerm
85 N21d7ae4e5f564279bf0679c143b15178 rdf:first sg:person.01234254420.48
86 rdf:rest N64a4302f94e64634968bfb5b0c915a43
87 N32eb75a558f94485aeb9e030b949704d rdf:first sg:person.010451630337.50
88 rdf:rest Nb71e658d95fe4bd2adc9d80f39caa42e
89 N4ee25604ad32408097a299e28ad9d819 rdf:first sg:person.0626706150.86
90 rdf:rest N69db5207db50474fb44aae3e4c4d7c6d
91 N64a4302f94e64634968bfb5b0c915a43 rdf:first sg:person.014333621177.38
92 rdf:rest N4ee25604ad32408097a299e28ad9d819
93 N659e8e817038447e8529b3f6e44913d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Interferon-gamma
95 rdf:type schema:DefinedTerm
96 N666dc91c62be4405aaabf2021ebf511f schema:name doi
97 schema:value 10.1038/nature04754
98 rdf:type schema:PropertyValue
99 N69db5207db50474fb44aae3e4c4d7c6d rdf:first sg:person.0724334003.08
100 rdf:rest Na8343f64e13340989e8cc0f572ee2264
101 N6d2388dddebe46b8bf2762751a2642c0 rdf:first sg:person.01101426743.93
102 rdf:rest N80a860b93066495cb46051163d3b2872
103 N74bebe8da29043b5855cdc3b16b03db0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Interleukins
105 rdf:type schema:DefinedTerm
106 N7e53d8b080894cee8400dbc1db897e6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Receptors, Interleukin
108 rdf:type schema:DefinedTerm
109 N80a860b93066495cb46051163d3b2872 rdf:first sg:person.0616302042.39
110 rdf:rest N9ded933144c7440aa58419ac7fbd67db
111 N9ded933144c7440aa58419ac7fbd67db rdf:first sg:person.01323502700.54
112 rdf:rest N21d7ae4e5f564279bf0679c143b15178
113 Na295c25d41f848f5bcd678dffdd1a810 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Interleukin-23 Subunit p19
115 rdf:type schema:DefinedTerm
116 Na8343f64e13340989e8cc0f572ee2264 rdf:first sg:person.01076747244.03
117 rdf:rest N32eb75a558f94485aeb9e030b949704d
118 Nac933aa14ef04a7d9142cf27b9c3bcae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mice
120 rdf:type schema:DefinedTerm
121 Nb02c85097760425ea0753fe55a6bc8f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Th1 Cells
123 rdf:type schema:DefinedTerm
124 Nb2223245afa74bf089e1ec8bb94f716f schema:name pubmed_id
125 schema:value 16648837
126 rdf:type schema:PropertyValue
127 Nb71e658d95fe4bd2adc9d80f39caa42e rdf:first sg:person.01031057040.19
128 rdf:rest rdf:nil
129 Nc2745ce162fb4d82aa9ca88d78818fae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Interleukin-4
131 rdf:type schema:DefinedTerm
132 Nc5211474ef1648f491b0c66e24f37c54 schema:name dimensions_id
133 schema:value pub.1043278106
134 rdf:type schema:PropertyValue
135 Ncd9ae5b96ddb4ecba0b1caa47c7b3492 schema:volumeNumber 441
136 rdf:type schema:PublicationVolume
137 Ncf776c32b3534423a2728778aedf3372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Th2 Cells
139 rdf:type schema:DefinedTerm
140 Nd3f0fe80a7824c8aa744091d5085f2fb schema:issueNumber 7090
141 rdf:type schema:PublicationIssue
142 Nd80bfc686609496f8182946c735ff6cd schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Nd8911db090564e07bcf05270f367b9ce schema:name readcube_id
145 schema:value ce25f26642640660360a9300d5656516e548c33270cf15c28e0b31055ee7392f
146 rdf:type schema:PropertyValue
147 Nf3e56f0699a247779e376cae512e4e56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Interleukin-23
149 rdf:type schema:DefinedTerm
150 Nf43efe14493040d7ab7d0a767f537730 schema:name nlm_unique_id
151 schema:value 0410462
152 rdf:type schema:PropertyValue
153 Nfbc5a1826ee04711be15399da8fe6b83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cell Differentiation
155 rdf:type schema:DefinedTerm
156 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
157 schema:name Biological Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
160 schema:name Biochemistry and Cell Biology
161 rdf:type schema:DefinedTerm
162 sg:grant.2681759 http://pending.schema.org/fundedItem sg:pub.10.1038/nature04754
163 rdf:type schema:MonetaryGrant
164 sg:grant.2715533 http://pending.schema.org/fundedItem sg:pub.10.1038/nature04754
165 rdf:type schema:MonetaryGrant
166 sg:grant.2724626 http://pending.schema.org/fundedItem sg:pub.10.1038/nature04754
167 rdf:type schema:MonetaryGrant
168 sg:journal.1018957 schema:issn 0090-0028
169 1476-4687
170 schema:name Nature
171 rdf:type schema:Periodical
172 sg:person.01031057040.19 schema:familyName Weaver
173 schema:givenName Casey T
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031057040.19
175 rdf:type schema:Person
176 sg:person.010451630337.50 schema:familyName Schoeb
177 schema:givenName Trenton R
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010451630337.50
179 rdf:type schema:Person
180 sg:person.01076747244.03 schema:familyName Wahl
181 schema:givenName Sharon M
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076747244.03
183 rdf:type schema:Person
184 sg:person.01101426743.93 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
185 schema:familyName Mangan
186 schema:givenName Paul R
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101426743.93
188 rdf:type schema:Person
189 sg:person.01234254420.48 schema:familyName Helms
190 schema:givenName Whitney S
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234254420.48
192 rdf:type schema:Person
193 sg:person.01323502700.54 schema:familyName O'Quinn
194 schema:givenName Darrell B
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323502700.54
196 rdf:type schema:Person
197 sg:person.014333621177.38 schema:familyName Bullard
198 schema:givenName Daniel C
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014333621177.38
200 rdf:type schema:Person
201 sg:person.0616302042.39 schema:familyName Harrington
202 schema:givenName Laurie E
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616302042.39
204 rdf:type schema:Person
205 sg:person.0626706150.86 schema:familyName Elson
206 schema:givenName Charles O
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626706150.86
208 rdf:type schema:Person
209 sg:person.0724334003.08 schema:familyName Hatton
210 schema:givenName Robin D
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724334003.08
212 rdf:type schema:Person
213 sg:pub.10.1038/359693a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015092130
214 https://doi.org/10.1038/359693a0
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nature01355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001374380
217 https://doi.org/10.1038/nature01355
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/ni1197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053117793
220 https://doi.org/10.1038/ni1197
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/ni1254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051485127
223 https://doi.org/10.1038/ni1254
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/ni1261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030750872
226 https://doi.org/10.1038/ni1261
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nri954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018494364
229 https://doi.org/10.1038/nri954
230 rdf:type schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1074462292 schema:CreativeWork
232 https://doi.org/10.1016/j.immuni.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009201806
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s1074-7613(00)00070-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023691475
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.0501701102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046921863
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1073/pnas.90.2.770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022493939
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1078/1438-4221-00247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048804774
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1084/jem.183.6.2669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033436331
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1084/jem.2001889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036910558
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1084/jem.20030152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048335036
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1084/jem.20030896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035188143
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1084/jem.20041257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013395893
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1084/jem.20050193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052433146
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/j.0105-2896.2004.00208.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040625620
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1128/iai.71.9.5077-5086.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017823378
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1128/iai.72.6.3315-3324.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044149152
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1146/annurev.immunol.24.021605.090737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043617931
261 rdf:type schema:CreativeWork
262 https://doi.org/10.4049/jimmunol.168.11.5699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037908336
263 rdf:type schema:CreativeWork
264 https://doi.org/10.4049/jimmunol.172.1.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016479186
265 rdf:type schema:CreativeWork
266 https://doi.org/10.4049/jimmunol.173.12.7249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012301348
267 rdf:type schema:CreativeWork
268 https://doi.org/10.4049/jimmunol.174.10.5950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077049003
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.265892.2 schema:alternateName University of Alabama at Birmingham
271 schema:name Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-2170, USA.
272 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...