hERG potassium channels and cardiac arrhythmia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-03

AUTHORS

Michael C. Sanguinetti, Martin Tristani-Firouzi

ABSTRACT

hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs. This side effect is a common reason for drug failure in preclinical safety trials. Insights gained from the crystal structures of other potassium channels have helped our understanding of the block of hERG channels and the mechanisms of gating. More... »

PAGES

463-469

References to SciGraph publications

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  • Journal

    TITLE

    Nature

    ISSUE

    7083

    VOLUME

    440

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature04710

    DOI

    http://dx.doi.org/10.1038/nature04710

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013279900

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16554806


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