Production of the antimalarial drug precursor artemisinic acid in engineered yeast View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Dae-Kyun Ro, Eric M. Paradise, Mario Ouellet, Karl J. Fisher, Karyn L. Newman, John M. Ndungu, Kimberly A. Ho, Rachel A. Eachus, Timothy S. Ham, James Kirby, Michelle C. Y. Chang, Sydnor T. Withers, Yoichiro Shiba, Richmond Sarpong, Jay D. Keasling

ABSTRACT

Battling malariaDrug-resistant strains of the malaria parasite are widespread, and as a result mortality due to malaria has increased significantly in recent years. Artemisinin, isolated from the herb Artemisia annua (sweet wormwood), is one drug that shows a high efficacy in killing multi-resistant strains of the parasite. The drug is extremely expensive, and high demand has led to a shortage of artemisinin, available only by extraction from the plant source. Ro et al. now report the development of a yeast strain engineered to carry a cytochrome P450 monooxygenase from A. annua that can produce the drug precursor, artemisinic acid. Artemisinin can be synthesized from this precursor. If the efficiency of this process can be improved, this engineered yeast strain has the potential to alleviate the drug shortage. More... »

PAGES

940-943

Journal

TITLE

Nature

ISSUE

7086

VOLUME

440

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature04640

DOI

http://dx.doi.org/10.1038/nature04640

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006120611

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16612385


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