Endothelial cells and VEGF in vascular development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-12-14

AUTHORS

Leigh Coultas, Kallayanee Chawengsaksophak, Janet Rossant

ABSTRACT

The intricate patterning processes that establish the complex vascular system during development depend on a combination of intrinsic pre-patterning and extrinsic responses to environmental parameters. Mutational studies in mice and fish have shown that the vascular system is highly sensitive to genetic disruption and have identified potential targets for therapeutic interventions. New insights into non-vascular roles of vascular endothelial growth factor and the requirement for endothelial cells in adult organs and stem-cell niches highlight possible side effects of anti-angiogenic therapy and the need for new targets. More... »

PAGES

937-945

References to SciGraph publications

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  • 2002-06. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism in NATURE
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature04479

    DOI

    http://dx.doi.org/10.1038/nature04479

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036852941

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16355211


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