Angiogenesis in life, disease and medicine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-12-14

AUTHORS

Peter Carmeliet

ABSTRACT

The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments. More... »

PAGES

932-936

Journal

TITLE

Nature

ISSUE

7070

VOLUME

438

Related Patents

  • Phosphaplatins And Their Use In The Treatment Of Cancers Resistant To Cisplatin And Carboplatin
  • Her-1, Her-3 And Igf-1r Compositions And Uses Thereof
  • Extracellular Allosteric Inhibitor Binding Domain From A Tyrosine Kinase Receptor
  • Anti-Cd160 Specific Antibodies For The Treatment Of Eye Disorders Based On Neoangiogenesis
  • Anti-Despr Inhibitors As Therapeutics For Inhibition Of Pathological Angiogenesis And Tumor Cell Invasiveness And For Molecular Imaging And Targeted Delivery
  • Use Of The Peptide Phpfhlfvy (Renin Inhibitor) In Anti-Angiogenic Therapy Of Certain Diseases
  • Methods For Treating Netosis And Neutrophil Activation
  • Phosphaplatins And Their Use In The Treatment Of Cancers Resistant To Cisplatin And Carboplatin
  • Despr Antagonists And Agonists As Therapeutics
  • Treatment Of Tumors Using Specific Anti-L1 Antibody
  • Treatment Of Tumors Using Specific Anti-L1 Antibody
  • Small Molecule Therapeutic Compounds That Reduce The Incidence Of Intracerebral Hemorrhage And Brain Microhemorrhages
  • Methods Of Prognosis And Diagnosis In Chronic Heart Failure
  • Methods For Enriching Adult-Derived Endothelial Progenitor Cells And Uses Thereof
  • Extracellular Allosteric Inhibitor Binding Domain From A Tyrosine Kinase Receptor
  • Proliferative Disease Treatment Methods With Phosphaplatin Complexes
  • Radiation Countermeasure Agents
  • Proliferative Disease Treatment Methods With Phosphaplatin Complexes
  • In Vivo Antiangiogenic Effect Of A Palladium Complex
  • Mimetic Peptides Derived From Collagen Type Iv And Their Use For Treating Angiogenesis- And Lymphangiogenesis-Dependent Diseases
  • Biomimetic Peptide And Biodegradable Delivery Platform For The Treatment Of Angiogenesis- And Lymphangiogenesis-Dependent Diseases
  • Mimetic Peptides Derived From Collagen Type Iv And Their Use For Treating Angiogenesis- And Lymphangiogenesis-Dependent Diseases
  • Her-1, Her-3 And Igf-1r Compositions And Uses Thereof
  • Methods For Using And Identifying Modulators Of Delta-Like 4
  • Mir For Treating Neo-Angiogenesis
  • Mirna For Treating Diseases And Conditions Associated With Neo-Angiogenesis
  • Biomimetic Peptide And Biodegradable Delivery Platform For The Treatment Of Angiogenesis- And Lymphangiogenesis-Dependent Diseases
  • G Proteins In Tumor Growth And Angiogenesis
  • Modulation Of Mirna In Diseases With Aberrant Angiogenesis
  • Substituted Pyridobenzodiazepinone-Derivatives And Use Thereof
  • Three-Dimensional Microfluidic Platforms And Methods Of Use Thereof
  • Phosphaplatin Complexes And Methods For Treatment Of Proliferative Diseases Using The Phosphaplatin Complexes
  • Phosphaplatins And Their Use For Treatment Of Cancers
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature04478

    DOI

    http://dx.doi.org/10.1038/nature04478

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011948458

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16355210


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Vessels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Pathologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Physiologic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), B-3000, Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), B-3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carmeliet", 
            "givenName": "Peter", 
            "id": "sg:person.01033041553.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033041553.19"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrc1456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022194278", 
              "https://doi.org/10.1038/nrc1456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020273083", 
              "https://doi.org/10.1038/nrc1586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010143012", 
              "https://doi.org/10.1038/nm0603-653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019159796", 
              "https://doi.org/10.1038/nrc1369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019336134", 
              "https://doi.org/10.1038/nature01322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncponc0403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035025701", 
              "https://doi.org/10.1038/ncponc0403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037571015", 
              "https://doi.org/10.1038/nm0603-702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017989667", 
              "https://doi.org/10.1038/ncb1288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001795574", 
              "https://doi.org/10.1038/nature04186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004418120", 
              "https://doi.org/10.1038/nm1285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/416279b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035406433", 
              "https://doi.org/10.1038/416279b"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029180571", 
              "https://doi.org/10.1038/nature03875"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2005-12-14", 
        "datePublishedReg": "2005-12-14", 
        "description": "The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature04478", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7070", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "438"
          }
        ], 
        "keywords": [
          "first anti-angiogenic agent", 
          "anti-angiogenic agents", 
          "anti-angiogenesis treatment", 
          "treatment of cancer", 
          "immune disorders", 
          "blood vessels", 
          "angiogenesis research", 
          "treatment", 
          "face of medicine", 
          "medicine", 
          "cancer", 
          "disease", 
          "disorders", 
          "angiogenesis", 
          "blindness", 
          "organ growth", 
          "repair", 
          "vessels", 
          "agents", 
          "imbalance", 
          "life", 
          "next decade", 
          "people", 
          "growth", 
          "decades", 
          "face", 
          "research", 
          "process"
        ], 
        "name": "Angiogenesis in life, disease and medicine", 
        "pagination": "932-936", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1011948458"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature04478"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16355210"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature04478", 
          "https://app.dimensions.ai/details/publication/pub.1011948458"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:14", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_406.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature04478"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature04478'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature04478'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature04478'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature04478'


     

    This table displays all metadata directly associated to this object as RDF triples.

    170 TRIPLES      22 PREDICATES      74 URIs      54 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature04478 schema:about N2a5fbf408b16484789ff7d126a3edee6
    2 N422f63716de54703b7ba06e9d026ea28
    3 N42d2e565e6a74c91bfcb7eb0ffa82490
    4 N5b36da3d20934b67ae46ce995777666d
    5 N7ec0d6918ccd4042ba364d9027eafebb
    6 N8b366f0d1df041738a65418850efc076
    7 Na691cc6e137a4ec2bc47b52d5764be23
    8 Nc62720c631744c6d8afa4a55798eb21a
    9 anzsrc-for:06
    10 anzsrc-for:0601
    11 schema:author Nb7c34b5fc4cb404290a49680ad63490c
    12 schema:citation sg:pub.10.1038/416279b
    13 sg:pub.10.1038/nature01322
    14 sg:pub.10.1038/nature03875
    15 sg:pub.10.1038/nature04186
    16 sg:pub.10.1038/ncb1288
    17 sg:pub.10.1038/ncponc0403
    18 sg:pub.10.1038/nm0603-653
    19 sg:pub.10.1038/nm0603-702
    20 sg:pub.10.1038/nm1285
    21 sg:pub.10.1038/nrc1369
    22 sg:pub.10.1038/nrc1456
    23 sg:pub.10.1038/nrc1586
    24 schema:datePublished 2005-12-14
    25 schema:datePublishedReg 2005-12-14
    26 schema:description The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.
    27 schema:genre article
    28 schema:inLanguage en
    29 schema:isAccessibleForFree false
    30 schema:isPartOf Nc2c641b2ceda49d1ae6c05e1065d81e2
    31 Ne194a268fb00445b996f5c91fd6cfd85
    32 sg:journal.1018957
    33 schema:keywords agents
    34 angiogenesis
    35 angiogenesis research
    36 anti-angiogenesis treatment
    37 anti-angiogenic agents
    38 blindness
    39 blood vessels
    40 cancer
    41 decades
    42 disease
    43 disorders
    44 face
    45 face of medicine
    46 first anti-angiogenic agent
    47 growth
    48 imbalance
    49 immune disorders
    50 life
    51 medicine
    52 next decade
    53 organ growth
    54 people
    55 process
    56 repair
    57 research
    58 treatment
    59 treatment of cancer
    60 vessels
    61 schema:name Angiogenesis in life, disease and medicine
    62 schema:pagination 932-936
    63 schema:productId N0be6f49070f84f04a2a8716f372e6fc0
    64 N945f783781974fe49b8b74811c379593
    65 Nb7e0ff98beb34eec95119303d0cb1d53
    66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011948458
    67 https://doi.org/10.1038/nature04478
    68 schema:sdDatePublished 2022-01-01T18:14
    69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    70 schema:sdPublisher N0cc4377eff834de4922f8985f3d04193
    71 schema:url https://doi.org/10.1038/nature04478
    72 sgo:license sg:explorer/license/
    73 sgo:sdDataset articles
    74 rdf:type schema:ScholarlyArticle
    75 N0be6f49070f84f04a2a8716f372e6fc0 schema:name doi
    76 schema:value 10.1038/nature04478
    77 rdf:type schema:PropertyValue
    78 N0cc4377eff834de4922f8985f3d04193 schema:name Springer Nature - SN SciGraph project
    79 rdf:type schema:Organization
    80 N2a5fbf408b16484789ff7d126a3edee6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    81 schema:name Blood Vessels
    82 rdf:type schema:DefinedTerm
    83 N422f63716de54703b7ba06e9d026ea28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    84 schema:name Humans
    85 rdf:type schema:DefinedTerm
    86 N42d2e565e6a74c91bfcb7eb0ffa82490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Drug Resistance, Neoplasm
    88 rdf:type schema:DefinedTerm
    89 N5b36da3d20934b67ae46ce995777666d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Neovascularization, Pathologic
    91 rdf:type schema:DefinedTerm
    92 N7ec0d6918ccd4042ba364d9027eafebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Neoplasms
    94 rdf:type schema:DefinedTerm
    95 N8b366f0d1df041738a65418850efc076 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Bone Marrow Cells
    97 rdf:type schema:DefinedTerm
    98 N945f783781974fe49b8b74811c379593 schema:name dimensions_id
    99 schema:value pub.1011948458
    100 rdf:type schema:PropertyValue
    101 Na691cc6e137a4ec2bc47b52d5764be23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Animals
    103 rdf:type schema:DefinedTerm
    104 Nb7c34b5fc4cb404290a49680ad63490c rdf:first sg:person.01033041553.19
    105 rdf:rest rdf:nil
    106 Nb7e0ff98beb34eec95119303d0cb1d53 schema:name pubmed_id
    107 schema:value 16355210
    108 rdf:type schema:PropertyValue
    109 Nc2c641b2ceda49d1ae6c05e1065d81e2 schema:issueNumber 7070
    110 rdf:type schema:PublicationIssue
    111 Nc62720c631744c6d8afa4a55798eb21a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Neovascularization, Physiologic
    113 rdf:type schema:DefinedTerm
    114 Ne194a268fb00445b996f5c91fd6cfd85 schema:volumeNumber 438
    115 rdf:type schema:PublicationVolume
    116 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    117 schema:name Biological Sciences
    118 rdf:type schema:DefinedTerm
    119 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    120 schema:name Biochemistry and Cell Biology
    121 rdf:type schema:DefinedTerm
    122 sg:journal.1018957 schema:issn 0028-0836
    123 1476-4687
    124 schema:name Nature
    125 schema:publisher Springer Nature
    126 rdf:type schema:Periodical
    127 sg:person.01033041553.19 schema:affiliation grid-institutes:grid.5596.f
    128 schema:familyName Carmeliet
    129 schema:givenName Peter
    130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033041553.19
    131 rdf:type schema:Person
    132 sg:pub.10.1038/416279b schema:sameAs https://app.dimensions.ai/details/publication/pub.1035406433
    133 https://doi.org/10.1038/416279b
    134 rdf:type schema:CreativeWork
    135 sg:pub.10.1038/nature01322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019336134
    136 https://doi.org/10.1038/nature01322
    137 rdf:type schema:CreativeWork
    138 sg:pub.10.1038/nature03875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029180571
    139 https://doi.org/10.1038/nature03875
    140 rdf:type schema:CreativeWork
    141 sg:pub.10.1038/nature04186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001795574
    142 https://doi.org/10.1038/nature04186
    143 rdf:type schema:CreativeWork
    144 sg:pub.10.1038/ncb1288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017989667
    145 https://doi.org/10.1038/ncb1288
    146 rdf:type schema:CreativeWork
    147 sg:pub.10.1038/ncponc0403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035025701
    148 https://doi.org/10.1038/ncponc0403
    149 rdf:type schema:CreativeWork
    150 sg:pub.10.1038/nm0603-653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010143012
    151 https://doi.org/10.1038/nm0603-653
    152 rdf:type schema:CreativeWork
    153 sg:pub.10.1038/nm0603-702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037571015
    154 https://doi.org/10.1038/nm0603-702
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.1038/nm1285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004418120
    157 https://doi.org/10.1038/nm1285
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1038/nrc1369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019159796
    160 https://doi.org/10.1038/nrc1369
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1038/nrc1456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022194278
    163 https://doi.org/10.1038/nrc1456
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1038/nrc1586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020273083
    166 https://doi.org/10.1038/nrc1586
    167 rdf:type schema:CreativeWork
    168 grid-institutes:grid.5596.f schema:alternateName Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), B-3000, Leuven, Belgium
    169 schema:name Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), B-3000, Leuven, Belgium
    170 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...