A protein interaction network of the malaria parasite Plasmodium falciparum View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-11

AUTHORS

Douglas J. LaCount, Marissa Vignali, Rakesh Chettier, Amit Phansalkar, Russell Bell, Jay R. Hesselberth, Lori W. Schoenfeld, Irene Ota, Sudhir Sahasrabudhe, Cornelia Kurschner, Stanley Fields, Robert E. Hughes

ABSTRACT

What makes a parasite tickA powerful approach for understanding protein function is to identify which proteins bind to each other, as protein complexes are at the heart of most biological processes. Protein–protein interactions have now been mapped for one quarter of the malaria parasite's proteins. This large data set sheds new light on how parasites infect red blood cells and will be a vital tool for the development of new antimalarial drugs and vaccines. The primary data are freely available on the PlasmoDB database. Suthram et al. have used this new resource and find that the Plasmodium network has significantly less cross-species similarity than other eukaryotes. Its novel life style is reflected in a novel protein network, which therefore has a good chance of providing drug targets unique to the malaria parasite. More... »

PAGES

103-107

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature04104

DOI

http://dx.doi.org/10.1038/nature04104

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041372966

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16267556


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