Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-07

AUTHORS

Duo Wang, Scott Kennedy, Darryl Conte, John K. Kim, Harrison W. Gabel, Ravi S. Kamath, Craig C. Mello, Gary Ruvkun

ABSTRACT

Caenorhabditis elegans homologues of the retinoblastoma (Rb) tumour suppressor complex specify cell lineage during development. Here we show that mutations in Rb pathway components enhance RNA interference (RNAi) and cause somatic cells to express genes and elaborate perinuclear structures normally limited to germline-specific P granules. Furthermore, particular gene inactivations that disrupt RNAi reverse the cell lineage transformations of Rb pathway mutants. These findings suggest that mutations in Rb pathway components cause cells to revert to patterns of gene expression normally restricted to germ cells. Rb may act by a similar mechanism to transform mammalian cells. More... »

PAGES

593

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature04010

DOI

http://dx.doi.org/10.1038/nature04010

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005872466

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16049496


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