WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-09

AUTHORS

Ivan B. Lobov, Sujata Rao, Thomas J. Carroll, Jefferson E. Vallance, Masataka Ito, Jennifer K. Ondr, Savita Kurup, Donald A. Glass, Millan S. Patel, Weiguo Shu, Edward E. Morrisey, Andrew P. McMahon, Gerard Karsenty, Richard A. Lang

ABSTRACT

Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells1. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway. We show in mice that macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions—including cell death—in adjacent cells, and raise the possibility that they do so in many different cellular contexts. More... »

PAGES

417-421

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature03928

DOI

http://dx.doi.org/10.1038/nature03928

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049568374

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16163358


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