Membrane vesicles traffic signals and facilitate group activities in a prokaryote View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-09

AUTHORS

Lauren M. Mashburn, Marvin Whiteley

ABSTRACT

Many bacteria use extracellular signals to communicate and coordinate social activities, a process referred to as quorum sensing. Many quorum signals have significant hydrophobic character, and how these signals are trafficked between bacteria within a population is not understood. Here we show that the opportunistic human pathogen Pseudomonas aeruginosa packages the signalling molecule 2-heptyl-3-hydroxy-4-quinolone (pseudomonas quinolone signal; PQS) into membrane vesicles that serve to traffic this molecule within a population. Removal of these vesicles from the bacterial population halts cell-cell communication and inhibits PQS-controlled group behaviour. We also show that PQS actively mediates its own packaging and the packaging of other antimicrobial quinolines produced by P. aeruginosa into vesicles. These findings illustrate that a prokaryote possesses a signal trafficking system with features common to those used by higher organisms and outlines a novel mechanism for delivery of a signal critical for coordinating group behaviour in P. aeruginosa. More... »

PAGES

422

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature03925

DOI

http://dx.doi.org/10.1038/nature03925

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016430291

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16163359


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