Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-07

AUTHORS

Yong Zhao, Eva Samal, Deepak Srivastava

ABSTRACT

Gradients of signalling and transcription factors govern many aspects of embryogenesis, highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are phylogenetically conserved small RNAs that regulate the translation of target messenger RNAs, providing a mechanism for protein dose regulation. Here we show that microRNA-1-1 (miR-1-1) and miR-1-2 are specifically expressed in cardiac and skeletal muscle precursor cells. We found that the miR-1 genes are direct transcriptional targets of muscle differentiation regulators including serum response factor, MyoD and Mef2. Correspondingly, excess miR-1 in the developing heart leads to a decreased pool of proliferating ventricular cardiomyocytes. Using a new algorithm for microRNA target identification that incorporates features of RNA structure and target accessibility, we show that Hand2, a transcription factor that promotes ventricular cardiomyocyte expansion, is a target of miR-1. This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis. More... »

PAGES

214-220

Journal

TITLE

Nature

ISSUE

7048

VOLUME

436

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature03817

    DOI

    http://dx.doi.org/10.1038/nature03817

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035771095

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15951802


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