Genes that mediate breast cancer metastasis to lung View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-07

AUTHORS

Andy J. Minn, Gaorav P. Gupta, Peter M. Siegel, Paula D. Bos, Weiping Shu, Dilip D. Giri, Agnes Viale, Adam B. Olshen, William L. Gerald, Joan Massagué

ABSTRACT

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis. More... »

PAGES

518

References to SciGraph publications

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  • Journal

    TITLE

    Nature

    ISSUE

    7050

    VOLUME

    436

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature03799

    DOI

    http://dx.doi.org/10.1038/nature03799

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030207920

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16049480


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