In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-06

AUTHORS

Dorothy A. Sipkins, Xunbin Wei, Juwell W. Wu, Judith M. Runnels, Daniel Côté, Terry K. Means, Andrew D. Luster, David T. Scadden, Charles P. Lin

ABSTRACT

The organization of cellular niches is known to have a key role in regulating normal stem cell differentiation and regeneration, but relatively little is known about the architecture of microenvironments that support malignant metastasis. Using dynamic in vivo confocal imaging, here we show that murine bone marrow contains unique anatomic regions defined by specialized endothelium. This vasculature expresses the adhesion molecule E-selectin and the chemoattractant stromal-cell-derived factor 1 (SDF-1) in discrete, discontinuous areas that influence the homing of a variety of tumour cell lines. Disruption of the interactions between SDF-1 and its receptor CXCR4 inhibits the homing of Nalm-6 cells (an acute lymphoblastic leukaemia cell line) to these vessels. Further studies revealed that circulating leukaemic cells can engraft around these vessels, suggesting that this molecularly distinct vasculature demarcates a microenvironment for early metastatic tumour spread in bone marrow. Finally, purified haematopoietic stem/progenitor cells and lymphocytes also localize to the same microdomains, indicating that this vasculature might also function in benign states to demarcate specific portals for the entry of cells into the marrow space. Specialized vascular structures therefore appear to delineate a microenvironment with unique physiology that can be exploited by circulating malignant cells. More... »

PAGES

969

Journal

TITLE

Nature

ISSUE

7044

VOLUME

435

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature03703

DOI

http://dx.doi.org/10.1038/nature03703

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033678207

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15959517


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "E-Selectin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Confocal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CXCR4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skull", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Wellman Center for Photomedicine, and", 
            "Center for Regenerative Medicine and Technology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, Massachusetts 02114, USA", 
            "Department of Hematology-Oncology, Massachusetts General Hospital and Dana-Farber Cancer Institute, Harvard Medical School, and"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sipkins", 
        "givenName": "Dorothy A.", 
        "id": "sg:person.0647217233.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647217233.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Wellman Center for Photomedicine, and"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Xunbin", 
        "id": "sg:person.01122647006.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122647006.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Wellman Center for Photomedicine, and"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Juwell W.", 
        "id": "sg:person.01110026351.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110026351.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Wellman Center for Photomedicine, and"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Runnels", 
        "givenName": "Judith M.", 
        "id": "sg:person.015401762407.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015401762407.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Wellman Center for Photomedicine, and"
          ], 
          "type": "Organization"
        }, 
        "familyName": "C\u00f4t\u00e9", 
        "givenName": "Daniel", 
        "id": "sg:person.01231421522.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231421522.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital East, Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Means", 
        "givenName": "Terry K.", 
        "id": "sg:person.0770046576.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770046576.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital East, Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luster", 
        "givenName": "Andrew D.", 
        "id": "sg:person.015041253314.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015041253314.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Center for Regenerative Medicine and Technology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, Massachusetts 02114, USA", 
            "Department of Hematology-Oncology, Massachusetts General Hospital and Dana-Farber Cancer Institute, Harvard Medical School, and", 
            "Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scadden", 
        "givenName": "David T.", 
        "id": "sg:person.0623550515.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623550515.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Wellman Center for Photomedicine, and"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Charles P.", 
        "id": "sg:person.01335255100.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335255100.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.184.3.1101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000274022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2637010100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004201622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008356436", 
          "https://doi.org/10.1038/35065016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008356436", 
          "https://doi.org/10.1038/35065016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-06-1891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009489961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00255-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013400830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdh136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015511257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200109133451113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016225712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019149476", 
          "https://doi.org/10.1038/nrc865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019149476", 
          "https://doi.org/10.1038/nrc865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(02)03143-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019265901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.188.3.465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023195775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-02-0663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024730443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90279-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025008911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031760793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci7615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032632257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2003.04326.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033590041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1022995403081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033727003", 
          "https://doi.org/10.1023/a:1022995403081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10428190290011921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035319036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.44.6.1667-1673.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039752461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.5.1925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044605520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(01)00741-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045815167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.16.9448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045854586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.16.9448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045854586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.03-0935fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049273881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01307187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049961968", 
          "https://doi.org/10.1007/bf01307187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01307187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049961968", 
          "https://doi.org/10.1007/bf01307187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/26/3/003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059020715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1097071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062449582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.283.5403.845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062564103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1364/ol.29.000077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065221504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.66.1.25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074493201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.8.5027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074795615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082404633", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-06", 
    "datePublishedReg": "2005-06-01", 
    "description": "The organization of cellular niches is known to have a key role in regulating normal stem cell differentiation and regeneration, but relatively little is known about the architecture of microenvironments that support malignant metastasis. Using dynamic in vivo confocal imaging, here we show that murine bone marrow contains unique anatomic regions defined by specialized endothelium. This vasculature expresses the adhesion molecule E-selectin and the chemoattractant stromal-cell-derived factor 1 (SDF-1) in discrete, discontinuous areas that influence the homing of a variety of tumour cell lines. Disruption of the interactions between SDF-1 and its receptor CXCR4 inhibits the homing of Nalm-6 cells (an acute lymphoblastic leukaemia cell line) to these vessels. Further studies revealed that circulating leukaemic cells can engraft around these vessels, suggesting that this molecularly distinct vasculature demarcates a microenvironment for early metastatic tumour spread in bone marrow. Finally, purified haematopoietic stem/progenitor cells and lymphocytes also localize to the same microdomains, indicating that this vasculature might also function in benign states to demarcate specific portals for the entry of cells into the marrow space. Specialized vascular structures therefore appear to delineate a microenvironment with unique physiology that can be exploited by circulating malignant cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature03703", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440157", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2507039", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682717", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2501166", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7044", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "435"
      }
    ], 
    "name": "In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment", 
    "pagination": "969", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a06ea998753e04c2109ec801c97314e9a769ef71b9650c41afdc9bba75301f0e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15959517"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature03703"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033678207"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature03703", 
      "https://app.dimensions.ai/details/publication/pub.1033678207"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87100_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature03703"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature03703'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature03703'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature03703'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature03703'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      75 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature03703 schema:about N0083eaccc6db46c0a92be0accd3ac341
2 N1bfb087d062b433cb3da8852f3250184
3 N22de9851c5614c35b17902bed40a03eb
4 N36c28b55986e4836ac3bf0e42f63b5b4
5 N6e99e1c2f04a48c9a25d92c0ae6053c5
6 N6f8e180b35cf4e28bac6a8c8208ed857
7 N733256986f894520ad94f66deb450fc9
8 N821cc585e7f346eebe8529db8f3b84b3
9 N9d898e03c3cc4a3596dc0c94793729ec
10 Na711cac1868c4eacbd49ccc7dec9bdc4
11 Ncaf08233a8724047988747591c3775c2
12 Nd4740cca07874cbe85bfd48a52f0a094
13 Nd9921083343041f5980f597f4715c7ea
14 Nd9bff748d6924aa3b443ca89074d2ab9
15 Nf78c5de6e3bc4be38c78c030a8fb27b3
16 Nfe430b0787f6419ea0ba35a898e91d02
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N3203cab58b8540a08a4fd97454937bcd
20 schema:citation sg:pub.10.1007/bf01307187
21 sg:pub.10.1023/a:1022995403081
22 sg:pub.10.1038/35065016
23 sg:pub.10.1038/nrc865
24 https://app.dimensions.ai/details/publication/pub.1082404633
25 https://doi.org/10.1002/jlb.66.1.25
26 https://doi.org/10.1016/0092-8674(91)90279-8
27 https://doi.org/10.1016/s0014-5793(02)03143-5
28 https://doi.org/10.1016/s0092-8674(04)00255-7
29 https://doi.org/10.1016/s0301-472x(01)00741-x
30 https://doi.org/10.1046/j.1365-2141.2003.04326.x
31 https://doi.org/10.1056/nejm200109133451113
32 https://doi.org/10.1073/pnas.2637010100
33 https://doi.org/10.1073/pnas.94.5.1925
34 https://doi.org/10.1073/pnas.95.16.9448
35 https://doi.org/10.1080/10428190290011921
36 https://doi.org/10.1084/jem.184.3.1101
37 https://doi.org/10.1084/jem.188.3.465
38 https://doi.org/10.1088/0031-9155/26/3/003
39 https://doi.org/10.1093/annonc/mdh136
40 https://doi.org/10.1096/fj.03-0935fje
41 https://doi.org/10.1126/science.1097071
42 https://doi.org/10.1126/science.283.5403.845
43 https://doi.org/10.1128/aac.44.6.1667-1673.2000
44 https://doi.org/10.1158/0008-5472.can-03-3693
45 https://doi.org/10.1172/jci7615
46 https://doi.org/10.1182/blood-2003-02-0663
47 https://doi.org/10.1182/blood-2003-06-1891
48 https://doi.org/10.1364/ol.29.000077
49 https://doi.org/10.4049/jimmunol.166.8.5027
50 schema:datePublished 2005-06
51 schema:datePublishedReg 2005-06-01
52 schema:description The organization of cellular niches is known to have a key role in regulating normal stem cell differentiation and regeneration, but relatively little is known about the architecture of microenvironments that support malignant metastasis. Using dynamic in vivo confocal imaging, here we show that murine bone marrow contains unique anatomic regions defined by specialized endothelium. This vasculature expresses the adhesion molecule E-selectin and the chemoattractant stromal-cell-derived factor 1 (SDF-1) in discrete, discontinuous areas that influence the homing of a variety of tumour cell lines. Disruption of the interactions between SDF-1 and its receptor CXCR4 inhibits the homing of Nalm-6 cells (an acute lymphoblastic leukaemia cell line) to these vessels. Further studies revealed that circulating leukaemic cells can engraft around these vessels, suggesting that this molecularly distinct vasculature demarcates a microenvironment for early metastatic tumour spread in bone marrow. Finally, purified haematopoietic stem/progenitor cells and lymphocytes also localize to the same microdomains, indicating that this vasculature might also function in benign states to demarcate specific portals for the entry of cells into the marrow space. Specialized vascular structures therefore appear to delineate a microenvironment with unique physiology that can be exploited by circulating malignant cells.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N0a7a70a421694098988d7dd7551eba9c
57 N3f1e78032389456d9464ac6331151dd6
58 sg:journal.1018957
59 schema:name In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment
60 schema:pagination 969
61 schema:productId N288cb8a24e6b405bbdbbb4ef88346555
62 N2cb0c5124b814ebc8c5f1f635e8a69b0
63 N93ef5ce324474f9bb71198d7f9513771
64 N985fac626d5e47e6937315b11a75d6aa
65 Nfb27f09efab449cc99586d14c48a3e51
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033678207
67 https://doi.org/10.1038/nature03703
68 schema:sdDatePublished 2019-04-11T12:24
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N6376c299728e47f4b4b52f1396dd1bad
71 schema:url https://www.nature.com/articles/nature03703
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0083eaccc6db46c0a92be0accd3ac341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Mice
77 rdf:type schema:DefinedTerm
78 N0a7a70a421694098988d7dd7551eba9c schema:volumeNumber 435
79 rdf:type schema:PublicationVolume
80 N13076f3e4e834a2495579605ec47cda9 rdf:first sg:person.0770046576.38
81 rdf:rest N9b96e520bce44650807ccd6ebf54ec12
82 N1523d8df35a74f538fbbfcb12adfdbf5 rdf:first sg:person.01335255100.17
83 rdf:rest rdf:nil
84 N18198c081ab840a391b5e1e215968ffa schema:name Center for Regenerative Medicine and Technology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, Massachusetts 02114, USA
85 Department of Hematology-Oncology, Massachusetts General Hospital and Dana-Farber Cancer Institute, Harvard Medical School, and
86 Wellman Center for Photomedicine, and
87 rdf:type schema:Organization
88 N1bfb087d062b433cb3da8852f3250184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Mice, SCID
90 rdf:type schema:DefinedTerm
91 N22de9851c5614c35b17902bed40a03eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cell Adhesion
93 rdf:type schema:DefinedTerm
94 N288cb8a24e6b405bbdbbb4ef88346555 schema:name doi
95 schema:value 10.1038/nature03703
96 rdf:type schema:PropertyValue
97 N2cb0c5124b814ebc8c5f1f635e8a69b0 schema:name dimensions_id
98 schema:value pub.1033678207
99 rdf:type schema:PropertyValue
100 N3203cab58b8540a08a4fd97454937bcd rdf:first sg:person.0647217233.97
101 rdf:rest N7af327f471bc43c8b94908bfa36841de
102 N36c28b55986e4836ac3bf0e42f63b5b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Animals
104 rdf:type schema:DefinedTerm
105 N3f1e78032389456d9464ac6331151dd6 schema:issueNumber 7044
106 rdf:type schema:PublicationIssue
107 N3f21e5132fdb4cdcb741e61a0758c68c schema:name Wellman Center for Photomedicine, and
108 rdf:type schema:Organization
109 N62da7acc032a43f2b7acfb39da2ce55d rdf:first sg:person.0623550515.44
110 rdf:rest N1523d8df35a74f538fbbfcb12adfdbf5
111 N6376c299728e47f4b4b52f1396dd1bad schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N683ae4fab04246879fc447b9b3e07a36 schema:name Wellman Center for Photomedicine, and
114 rdf:type schema:Organization
115 N6e99e1c2f04a48c9a25d92c0ae6053c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Line, Tumor
117 rdf:type schema:DefinedTerm
118 N6f867147bcc2404693fa5a4ffbddcc2a rdf:first sg:person.015401762407.65
119 rdf:rest N92e6c270c3ac4bcc992f58accf189db2
120 N6f8e180b35cf4e28bac6a8c8208ed857 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cell Movement
122 rdf:type schema:DefinedTerm
123 N733256986f894520ad94f66deb450fc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Endothelial Cells
125 rdf:type schema:DefinedTerm
126 N7a7c33e2aa2d42f2a9def7dffc7251f6 rdf:first sg:person.01110026351.63
127 rdf:rest N6f867147bcc2404693fa5a4ffbddcc2a
128 N7af327f471bc43c8b94908bfa36841de rdf:first sg:person.01122647006.79
129 rdf:rest N7a7c33e2aa2d42f2a9def7dffc7251f6
130 N821cc585e7f346eebe8529db8f3b84b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name E-Selectin
132 rdf:type schema:DefinedTerm
133 N92e6c270c3ac4bcc992f58accf189db2 rdf:first sg:person.01231421522.42
134 rdf:rest N13076f3e4e834a2495579605ec47cda9
135 N93ef5ce324474f9bb71198d7f9513771 schema:name nlm_unique_id
136 schema:value 0410462
137 rdf:type schema:PropertyValue
138 N985fac626d5e47e6937315b11a75d6aa schema:name readcube_id
139 schema:value a06ea998753e04c2109ec801c97314e9a769ef71b9650c41afdc9bba75301f0e
140 rdf:type schema:PropertyValue
141 N9b96e520bce44650807ccd6ebf54ec12 rdf:first sg:person.015041253314.00
142 rdf:rest N62da7acc032a43f2b7acfb39da2ce55d
143 N9d898e03c3cc4a3596dc0c94793729ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Leukemia
145 rdf:type schema:DefinedTerm
146 Na711cac1868c4eacbd49ccc7dec9bdc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Receptors, CXCR4
148 rdf:type schema:DefinedTerm
149 Nbcacb0d6bf8f48ad8c2176dc7de4332d schema:name Wellman Center for Photomedicine, and
150 rdf:type schema:Organization
151 Ncaf08233a8724047988747591c3775c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Neoplasms
153 rdf:type schema:DefinedTerm
154 Nd4740cca07874cbe85bfd48a52f0a094 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Cytokines
156 rdf:type schema:DefinedTerm
157 Nd9921083343041f5980f597f4715c7ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Bone Marrow Cells
159 rdf:type schema:DefinedTerm
160 Nd9bff748d6924aa3b443ca89074d2ab9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Skull
162 rdf:type schema:DefinedTerm
163 Nee8eb2b0aeb24869a3c2bc984f9a8a71 schema:name Wellman Center for Photomedicine, and
164 rdf:type schema:Organization
165 Nefb4abb261e546c8833000ab259cbe98 schema:name Wellman Center for Photomedicine, and
166 rdf:type schema:Organization
167 Nf78c5de6e3bc4be38c78c030a8fb27b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Microscopy, Confocal
169 rdf:type schema:DefinedTerm
170 Nfb27f09efab449cc99586d14c48a3e51 schema:name pubmed_id
171 schema:value 15959517
172 rdf:type schema:PropertyValue
173 Nfe430b0787f6419ea0ba35a898e91d02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mice, Inbred BALB C
175 rdf:type schema:DefinedTerm
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
180 schema:name Oncology and Carcinogenesis
181 rdf:type schema:DefinedTerm
182 sg:grant.2440157 http://pending.schema.org/fundedItem sg:pub.10.1038/nature03703
183 rdf:type schema:MonetaryGrant
184 sg:grant.2501166 http://pending.schema.org/fundedItem sg:pub.10.1038/nature03703
185 rdf:type schema:MonetaryGrant
186 sg:grant.2507039 http://pending.schema.org/fundedItem sg:pub.10.1038/nature03703
187 rdf:type schema:MonetaryGrant
188 sg:grant.2682717 http://pending.schema.org/fundedItem sg:pub.10.1038/nature03703
189 rdf:type schema:MonetaryGrant
190 sg:journal.1018957 schema:issn 0090-0028
191 1476-4687
192 schema:name Nature
193 rdf:type schema:Periodical
194 sg:person.01110026351.63 schema:affiliation N3f21e5132fdb4cdcb741e61a0758c68c
195 schema:familyName Wu
196 schema:givenName Juwell W.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110026351.63
198 rdf:type schema:Person
199 sg:person.01122647006.79 schema:affiliation Nee8eb2b0aeb24869a3c2bc984f9a8a71
200 schema:familyName Wei
201 schema:givenName Xunbin
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122647006.79
203 rdf:type schema:Person
204 sg:person.01231421522.42 schema:affiliation Nbcacb0d6bf8f48ad8c2176dc7de4332d
205 schema:familyName Côté
206 schema:givenName Daniel
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231421522.42
208 rdf:type schema:Person
209 sg:person.01335255100.17 schema:affiliation N683ae4fab04246879fc447b9b3e07a36
210 schema:familyName Lin
211 schema:givenName Charles P.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335255100.17
213 rdf:type schema:Person
214 sg:person.015041253314.00 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
215 schema:familyName Luster
216 schema:givenName Andrew D.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015041253314.00
218 rdf:type schema:Person
219 sg:person.015401762407.65 schema:affiliation Nefb4abb261e546c8833000ab259cbe98
220 schema:familyName Runnels
221 schema:givenName Judith M.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015401762407.65
223 rdf:type schema:Person
224 sg:person.0623550515.44 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
225 schema:familyName Scadden
226 schema:givenName David T.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623550515.44
228 rdf:type schema:Person
229 sg:person.0647217233.97 schema:affiliation N18198c081ab840a391b5e1e215968ffa
230 schema:familyName Sipkins
231 schema:givenName Dorothy A.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647217233.97
233 rdf:type schema:Person
234 sg:person.0770046576.38 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
235 schema:familyName Means
236 schema:givenName Terry K.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770046576.38
238 rdf:type schema:Person
239 sg:pub.10.1007/bf01307187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049961968
240 https://doi.org/10.1007/bf01307187
241 rdf:type schema:CreativeWork
242 sg:pub.10.1023/a:1022995403081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033727003
243 https://doi.org/10.1023/a:1022995403081
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/35065016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008356436
246 https://doi.org/10.1038/35065016
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nrc865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019149476
249 https://doi.org/10.1038/nrc865
250 rdf:type schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1082404633 schema:CreativeWork
252 https://doi.org/10.1002/jlb.66.1.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074493201
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/0092-8674(91)90279-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025008911
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0014-5793(02)03143-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019265901
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0092-8674(04)00255-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013400830
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0301-472x(01)00741-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045815167
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1046/j.1365-2141.2003.04326.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033590041
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1056/nejm200109133451113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016225712
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1073/pnas.2637010100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004201622
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1073/pnas.94.5.1925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044605520
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1073/pnas.95.16.9448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045854586
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1080/10428190290011921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035319036
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1084/jem.184.3.1101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000274022
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1084/jem.188.3.465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023195775
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1088/0031-9155/26/3/003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059020715
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1093/annonc/mdh136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015511257
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1096/fj.03-0935fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1049273881
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1126/science.1097071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449582
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1126/science.283.5403.845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062564103
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1128/aac.44.6.1667-1673.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039752461
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1158/0008-5472.can-03-3693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031760793
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1172/jci7615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032632257
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1182/blood-2003-02-0663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024730443
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1182/blood-2003-06-1891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009489961
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1364/ol.29.000077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065221504
299 rdf:type schema:CreativeWork
300 https://doi.org/10.4049/jimmunol.166.8.5027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074795615
301 rdf:type schema:CreativeWork
302 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
303 schema:name Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital East, Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
304 Center for Regenerative Medicine and Technology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, Massachusetts 02114, USA
305 Department of Hematology-Oncology, Massachusetts General Hospital and Dana-Farber Cancer Institute, Harvard Medical School, and
306 Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...