Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-06

AUTHORS

Johan H. van Es, Marielle E. van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J. Winton, Freddy Radtke, Hans Clevers

ABSTRACT

Alzheimer's drugs for cancer?Notch genes encode a range of membrane receptors that regulate cell-fate decisions by influencing communication between adjacent cells. Two groups now report the involvement of Notch signals in controlling the fate of intestinal epithelial tissue. In addition, blockade of the Notch pathway with the γ-secretase inhibitor DBZ halted growth of adenomas (polyps) in the small intestine and colon. Various γ-secretase inhibitors are being developed for the treatment of Alzheimer's disease; this new work suggests that they might also be used to treat colorectal cancers. More... »

PAGES

959-963

Journal

TITLE

Nature

ISSUE

7044

VOLUME

435

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature03659

    DOI

    http://dx.doi.org/10.1038/nature03659

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046707660

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15959515


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