Ontology type: schema:ScholarlyArticle
2005-06
AUTHORSJohan H. van Es, Marielle E. van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J. Winton, Freddy Radtke, Hans Clevers
ABSTRACTAlzheimer's drugs for cancer?Notch genes encode a range of membrane receptors that regulate cell-fate decisions by influencing communication between adjacent cells. Two groups now report the involvement of Notch signals in controlling the fate of intestinal epithelial tissue. In addition, blockade of the Notch pathway with the γ-secretase inhibitor DBZ halted growth of adenomas (polyps) in the small intestine and colon. Various γ-secretase inhibitors are being developed for the treatment of Alzheimer's disease; this new work suggests that they might also be used to treat colorectal cancers. More... »
PAGES959-963
http://scigraph.springernature.com/pub.10.1038/nature03659
DOIhttp://dx.doi.org/10.1038/nature03659
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15959515
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