Notch signals control the fate of immature progenitor cells in the intestine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-06

AUTHORS

Silvia Fre, Mathilde Huyghe, Philippos Mourikis, Sylvie Robine, Daniel Louvard, Spyros Artavanis-Tsakonas

ABSTRACT

Alzheimer's drugs for cancer?Notch genes encode a range of membrane receptors that regulate cell-fate decisions by influencing communication between adjacent cells. Two groups now report the involvement of Notch signals in controlling the fate of intestinal epithelial tissue. In addition, blockade of the Notch pathway with the γ-secretase inhibitor DBZ halted growth of adenomas (polyps) in the small intestine and colon. Various γ-secretase inhibitors are being developed for the treatment of Alzheimer's disease; this new work suggests that they might also be used to treat colorectal cancers. More... »

PAGES

964-968

Journal

TITLE

Nature

ISSUE

7044

VOLUME

435

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature03589

    DOI

    http://dx.doi.org/10.1038/nature03589

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015449829

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15959516


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