Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-04

AUTHORS

Vassilis G. Gorgoulis, Leandros-Vassilios F. Vassiliou, Panagiotis Karakaidos, Panayotis Zacharatos, Athanassios Kotsinas, Triantafillos Liloglou, Monica Venere, Richard A. DiTullio, Nikolaos G. Kastrinakis, Brynn Levy, Dimitris Kletsas, Akihiro Yoneta, Meenhard Herlyn, Christos Kittas, Thanos D. Halazonetis

ABSTRACT

DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but the selective pressure for their inactivation remains elusive. We analysed a panel of human lung hyperplasias, all of which retained wild-type p53 genes and had no signs of gross chromosomal instability, and found signs of a DNA damage response, including histone H2AX and Chk2 phosphorylation, p53 accumulation, focal staining of p53 binding protein 1 (53BP1) and apoptosis. Progression to carcinoma was associated with p53 or 53BP1 inactivation and decreased apoptosis. A DNA damage response was also observed in dysplastic nevi and in human skin xenografts, in which hyperplasia was induced by overexpression of growth factors. Both lung and experimentally-induced skin hyperplasias showed allelic imbalance at loci that are prone to DNA double-strand break formation when DNA replication is compromised (common fragile sites). We propose that, from its earliest stages, cancer development is associated with DNA replication stress, which leads to DNA double-strand breaks, genomic instability and selective pressure for p53 mutations. More... »

PAGES

907

Journal

TITLE

Nature

ISSUE

7035

VOLUME

434

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature03485

DOI

http://dx.doi.org/10.1038/nature03485

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005294665

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15829965


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