CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-03

AUTHORS

Edith M. Janssen, Nathalie M. Droin, Edward E. Lemmens, Michael J. Pinkoski, Steven J. Bensinger, Benjamin D. Ehst, Thomas S. Griffith, Douglas R. Green, Stephen P. Schoenberger

ABSTRACT

The 'help' provided by CD4+ T lymphocytes during the priming of CD8+ T lymphocytes confers a key feature of immune memory: the capacity for autonomous secondary expansion following re-encounter with antigen. Once primed in the presence of CD4+ T cells, 'helped' CD8+ T cells acquire the ability to undergo a second round of clonal expansion upon restimulation in the absence of T-cell help. 'Helpless' CD8+ T cells that are primed in the absence of CD4+ T cells, in contrast, can mediate effector functions such as cytotoxicity and cytokine secretion upon restimulation, but do not undergo a second round of clonal expansion. These disparate responses have features of being 'programmed', that is, guided by signals that are transmitted to naive CD8+ T cells during priming, which encode specific fates for their clonal progeny. Here we explore the instructional programme that governs the secondary response of CD8+ T cells and find that helpless cells undergo death by activation-induced cell death upon secondary stimulation. This death is mediated by tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Regulation of Trail expression can therefore account for the role of CD4+ T cells in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive immune responses. More... »

PAGES

88

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature03337

DOI

http://dx.doi.org/10.1038/nature03337

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032156352

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15744305


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunologic Memory", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TNF-Related Apoptosis-Inducing Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "La Jolla Institute For Allergy & Immunology", 
          "id": "https://www.grid.ac/institutes/grid.185006.a", 
          "name": [
            "Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janssen", 
        "givenName": "Edith M.", 
        "id": "sg:person.01137022657.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137022657.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "La Jolla Institute For Allergy & Immunology", 
          "id": "https://www.grid.ac/institutes/grid.185006.a", 
          "name": [
            "Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Droin", 
        "givenName": "Nathalie M.", 
        "id": "sg:person.01303425742.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303425742.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "La Jolla Institute For Allergy & Immunology", 
          "id": "https://www.grid.ac/institutes/grid.185006.a", 
          "name": [
            "Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lemmens", 
        "givenName": "Edward E.", 
        "id": "sg:person.013712233607.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013712233607.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "La Jolla Institute For Allergy & Immunology", 
          "id": "https://www.grid.ac/institutes/grid.185006.a", 
          "name": [
            "Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinkoski", 
        "givenName": "Michael J.", 
        "id": "sg:person.01167012040.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167012040.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "La Jolla Institute For Allergy & Immunology", 
          "id": "https://www.grid.ac/institutes/grid.185006.a", 
          "name": [
            "Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bensinger", 
        "givenName": "Steven J.", 
        "id": "sg:person.01237364431.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237364431.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ehst", 
        "givenName": "Benjamin D.", 
        "id": "sg:person.01244174001.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244174001.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Iowa", 
          "id": "https://www.grid.ac/institutes/grid.214572.7", 
          "name": [
            "Department of Urology, The Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa 52242, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griffith", 
        "givenName": "Thomas S.", 
        "id": "sg:person.01100764416.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100764416.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "La Jolla Institute For Allergy & Immunology", 
          "id": "https://www.grid.ac/institutes/grid.185006.a", 
          "name": [
            "Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Green", 
        "givenName": "Douglas R.", 
        "id": "sg:person.012546343032.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012546343032.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "La Jolla Institute For Allergy & Immunology", 
          "id": "https://www.grid.ac/institutes/grid.185006.a", 
          "name": [
            "Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schoenberger", 
        "givenName": "Stephen P.", 
        "id": "sg:person.0600674352.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600674352.93"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ni1105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002688434", 
          "https://doi.org/10.1038/ni1105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002688434", 
          "https://doi.org/10.1038/ni1105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208167200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005728757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.185.12.2043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008642047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90057-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012226119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013101769", 
          "https://doi.org/10.1038/sj.cdd.4401138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013101769", 
          "https://doi.org/10.1038/sj.cdd.4401138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1600-6135.2003.00246.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015154154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/87730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018365256", 
          "https://doi.org/10.1038/87730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00502-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021790463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.17.5386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028431262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90362-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028488714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1025319031417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033012895", 
          "https://doi.org/10.1023/a:1025319031417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.3.1356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033991928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.22.12687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037131813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037702320", 
          "https://doi.org/10.1038/nri1184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037702320", 
          "https://doi.org/10.1038/nri1184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037702320", 
          "https://doi.org/10.1038/nri1184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038925353", 
          "https://doi.org/10.1038/nature01441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038925353", 
          "https://doi.org/10.1038/nature01441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(94)90236-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041861549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(94)90236-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041861549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.182.6.1973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043714315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199809)28:09<2714::aid-immu2714>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044389785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199809)28:09<2714::aid-immu2714>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044389785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.21.7638-7647.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049411262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.41.25417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050349376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1072615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062446627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1082305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062447916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1083317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5327.815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062557614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081732150", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083332919", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-03", 
    "datePublishedReg": "2005-03-01", 
    "description": "The 'help' provided by CD4+ T lymphocytes during the priming of CD8+ T lymphocytes confers a key feature of immune memory: the capacity for autonomous secondary expansion following re-encounter with antigen. Once primed in the presence of CD4+ T cells, 'helped' CD8+ T cells acquire the ability to undergo a second round of clonal expansion upon restimulation in the absence of T-cell help. 'Helpless' CD8+ T cells that are primed in the absence of CD4+ T cells, in contrast, can mediate effector functions such as cytotoxicity and cytokine secretion upon restimulation, but do not undergo a second round of clonal expansion. These disparate responses have features of being 'programmed', that is, guided by signals that are transmitted to naive CD8+ T cells during priming, which encode specific fates for their clonal progeny. Here we explore the instructional programme that governs the secondary response of CD8+ T cells and find that helpless cells undergo death by activation-induced cell death upon secondary stimulation. This death is mediated by tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Regulation of Trail expression can therefore account for the role of CD4+ T cells in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive immune responses.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature03337", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7029", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "434"
      }
    ], 
    "name": "CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death", 
    "pagination": "88", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "992f971dc521d7bd1f5f6b29d61bba6565f2ee2331c6da2ea95e812ce891dc83"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15744305"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature03337"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032156352"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature03337", 
      "https://app.dimensions.ai/details/publication/pub.1032156352"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87115_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature03337"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature03337'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature03337'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature03337'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature03337'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      70 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature03337 schema:about N03dd27ab894443adb4732814c8926723
2 N09c8b85d77ef43c7ac8cf23cc15aecce
3 N224cec46a51141799b2ca671713bd52f
4 N3d43cd91c563424a87593e8155fc513e
5 N5a94a597ce86402ca34f526c1e307ea3
6 N5b36e3b7906a47b0850f52b96b029f5a
7 N7501bee46b2e4ee9b14fd30977aaad22
8 N886a70de48354bc9be24d7912848d080
9 N9c034d11303f4876a382ffe50b1d979a
10 Na281bf055e4748229962d96a9dc91a5b
11 Nb2b856d6a8d94774990c6b9a8950ebc0
12 Nc71bd8d0513e4cde92974e3191c0af00
13 Nf3e95e0c35924a319e8e6c4fb32909ba
14 Nf6c1f9d1fdec467d9140be87bf3f8543
15 Nffd75026a15a43b2b0aac54d5fef4c85
16 anzsrc-for:11
17 anzsrc-for:1107
18 schema:author Nd90ab97ec8c94d4c9ae226edd55a53f8
19 schema:citation sg:pub.10.1023/a:1025319031417
20 sg:pub.10.1038/87730
21 sg:pub.10.1038/nature01441
22 sg:pub.10.1038/ni1105
23 sg:pub.10.1038/nri1184
24 sg:pub.10.1038/sj.cdd.4401138
25 https://app.dimensions.ai/details/publication/pub.1081732150
26 https://app.dimensions.ai/details/publication/pub.1083332919
27 https://doi.org/10.1002/(sici)1521-4141(199809)28:09<2714::aid-immu2714>3.0.co;2-9
28 https://doi.org/10.1016/0022-1759(94)90236-4
29 https://doi.org/10.1016/0092-8674(91)90362-3
30 https://doi.org/10.1016/1074-7613(95)90057-8
31 https://doi.org/10.1016/s1074-7613(02)00502-2
32 https://doi.org/10.1046/j.1600-6135.2003.00246.x
33 https://doi.org/10.1074/jbc.271.22.12687
34 https://doi.org/10.1074/jbc.272.41.25417
35 https://doi.org/10.1074/jbc.m208167200
36 https://doi.org/10.1084/jem.182.6.1973
37 https://doi.org/10.1084/jem.185.12.2043
38 https://doi.org/10.1093/emboj/16.17.5386
39 https://doi.org/10.1126/science.1072615
40 https://doi.org/10.1126/science.1082305
41 https://doi.org/10.1126/science.1083317
42 https://doi.org/10.1126/science.277.5327.815
43 https://doi.org/10.1128/mcb.23.21.7638-7647.2003
44 https://doi.org/10.4049/jimmunol.168.3.1356
45 schema:datePublished 2005-03
46 schema:datePublishedReg 2005-03-01
47 schema:description The 'help' provided by CD4+ T lymphocytes during the priming of CD8+ T lymphocytes confers a key feature of immune memory: the capacity for autonomous secondary expansion following re-encounter with antigen. Once primed in the presence of CD4+ T cells, 'helped' CD8+ T cells acquire the ability to undergo a second round of clonal expansion upon restimulation in the absence of T-cell help. 'Helpless' CD8+ T cells that are primed in the absence of CD4+ T cells, in contrast, can mediate effector functions such as cytotoxicity and cytokine secretion upon restimulation, but do not undergo a second round of clonal expansion. These disparate responses have features of being 'programmed', that is, guided by signals that are transmitted to naive CD8+ T cells during priming, which encode specific fates for their clonal progeny. Here we explore the instructional programme that governs the secondary response of CD8+ T cells and find that helpless cells undergo death by activation-induced cell death upon secondary stimulation. This death is mediated by tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Regulation of Trail expression can therefore account for the role of CD4+ T cells in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive immune responses.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N64a83e17207a46248d279e68d9a1d0b3
52 Nc892a5b6f12b4c358d7444d5fec7783f
53 sg:journal.1018957
54 schema:name CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
55 schema:pagination 88
56 schema:productId N0ccdbea8a31c43ff86f4d1a44ef481bf
57 N1cac0d701c46460894db17295ebe83f9
58 N2df787e036a547b59ebad10e8c9d6011
59 N468f5fa1cef84921b75612c18e77447b
60 N8c1a2cb0460f47c5beeff1bf3c2055d2
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032156352
62 https://doi.org/10.1038/nature03337
63 schema:sdDatePublished 2019-04-11T12:27
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N79e5d6edd893425489ca38705e98ccf3
66 schema:url https://www.nature.com/articles/nature03337
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N03dd27ab894443adb4732814c8926723 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Caspases
72 rdf:type schema:DefinedTerm
73 N09c8b85d77ef43c7ac8cf23cc15aecce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Immunologic Memory
75 rdf:type schema:DefinedTerm
76 N0ccdbea8a31c43ff86f4d1a44ef481bf schema:name pubmed_id
77 schema:value 15744305
78 rdf:type schema:PropertyValue
79 N1cac0d701c46460894db17295ebe83f9 schema:name readcube_id
80 schema:value 992f971dc521d7bd1f5f6b29d61bba6565f2ee2331c6da2ea95e812ce891dc83
81 rdf:type schema:PropertyValue
82 N224cec46a51141799b2ca671713bd52f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Lymphocyte Activation
84 rdf:type schema:DefinedTerm
85 N29175b47e7d7424287803eca4004cf77 rdf:first sg:person.013712233607.18
86 rdf:rest N2adc78b5137c4b7cb6db1537d3609ecb
87 N2adc78b5137c4b7cb6db1537d3609ecb rdf:first sg:person.01167012040.19
88 rdf:rest N4fa1b00d6bd8414b9b707df4716f3554
89 N2df787e036a547b59ebad10e8c9d6011 schema:name doi
90 schema:value 10.1038/nature03337
91 rdf:type schema:PropertyValue
92 N3d43cd91c563424a87593e8155fc513e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Tumor Necrosis Factor-alpha
94 rdf:type schema:DefinedTerm
95 N468f5fa1cef84921b75612c18e77447b schema:name nlm_unique_id
96 schema:value 0410462
97 rdf:type schema:PropertyValue
98 N4fa1b00d6bd8414b9b707df4716f3554 rdf:first sg:person.01237364431.53
99 rdf:rest N752db9f18d0e4a6793388e670aa8e9eb
100 N5a94a597ce86402ca34f526c1e307ea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Apoptosis
102 rdf:type schema:DefinedTerm
103 N5b36e3b7906a47b0850f52b96b029f5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Membrane Glycoproteins
105 rdf:type schema:DefinedTerm
106 N64a83e17207a46248d279e68d9a1d0b3 schema:issueNumber 7029
107 rdf:type schema:PublicationIssue
108 N6ac1a7e3a02a40098ffb231471230f3d rdf:first sg:person.012546343032.89
109 rdf:rest Nc141b78e3ab342219d03a987d7b98b86
110 N6cfd83b397d6473aae043310a10007cb rdf:first sg:person.01100764416.76
111 rdf:rest N6ac1a7e3a02a40098ffb231471230f3d
112 N7501bee46b2e4ee9b14fd30977aaad22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Cells, Cultured
114 rdf:type schema:DefinedTerm
115 N752db9f18d0e4a6793388e670aa8e9eb rdf:first sg:person.01244174001.36
116 rdf:rest N6cfd83b397d6473aae043310a10007cb
117 N79e5d6edd893425489ca38705e98ccf3 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N7b3aca5154264be9b19b410c7efc7726 rdf:first sg:person.01303425742.13
120 rdf:rest N29175b47e7d7424287803eca4004cf77
121 N886a70de48354bc9be24d7912848d080 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Animals
123 rdf:type schema:DefinedTerm
124 N8c1a2cb0460f47c5beeff1bf3c2055d2 schema:name dimensions_id
125 schema:value pub.1032156352
126 rdf:type schema:PropertyValue
127 N9c034d11303f4876a382ffe50b1d979a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name CD8-Positive T-Lymphocytes
129 rdf:type schema:DefinedTerm
130 Na281bf055e4748229962d96a9dc91a5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name TNF-Related Apoptosis-Inducing Ligand
132 rdf:type schema:DefinedTerm
133 Nb2b856d6a8d94774990c6b9a8950ebc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Mice
135 rdf:type schema:DefinedTerm
136 Nc141b78e3ab342219d03a987d7b98b86 rdf:first sg:person.0600674352.93
137 rdf:rest rdf:nil
138 Nc71bd8d0513e4cde92974e3191c0af00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name RNA, Messenger
140 rdf:type schema:DefinedTerm
141 Nc892a5b6f12b4c358d7444d5fec7783f schema:volumeNumber 434
142 rdf:type schema:PublicationVolume
143 Nd90ab97ec8c94d4c9ae226edd55a53f8 rdf:first sg:person.01137022657.89
144 rdf:rest N7b3aca5154264be9b19b410c7efc7726
145 Nf3e95e0c35924a319e8e6c4fb32909ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Apoptosis Regulatory Proteins
147 rdf:type schema:DefinedTerm
148 Nf6c1f9d1fdec467d9140be87bf3f8543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Caspase Inhibitors
150 rdf:type schema:DefinedTerm
151 Nffd75026a15a43b2b0aac54d5fef4c85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name CD4-Positive T-Lymphocytes
153 rdf:type schema:DefinedTerm
154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical and Health Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
158 schema:name Immunology
159 rdf:type schema:DefinedTerm
160 sg:journal.1018957 schema:issn 0090-0028
161 1476-4687
162 schema:name Nature
163 rdf:type schema:Periodical
164 sg:person.01100764416.76 schema:affiliation https://www.grid.ac/institutes/grid.214572.7
165 schema:familyName Griffith
166 schema:givenName Thomas S.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100764416.76
168 rdf:type schema:Person
169 sg:person.01137022657.89 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
170 schema:familyName Janssen
171 schema:givenName Edith M.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137022657.89
173 rdf:type schema:Person
174 sg:person.01167012040.19 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
175 schema:familyName Pinkoski
176 schema:givenName Michael J.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167012040.19
178 rdf:type schema:Person
179 sg:person.01237364431.53 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
180 schema:familyName Bensinger
181 schema:givenName Steven J.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237364431.53
183 rdf:type schema:Person
184 sg:person.01244174001.36 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
185 schema:familyName Ehst
186 schema:givenName Benjamin D.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244174001.36
188 rdf:type schema:Person
189 sg:person.012546343032.89 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
190 schema:familyName Green
191 schema:givenName Douglas R.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012546343032.89
193 rdf:type schema:Person
194 sg:person.01303425742.13 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
195 schema:familyName Droin
196 schema:givenName Nathalie M.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303425742.13
198 rdf:type schema:Person
199 sg:person.013712233607.18 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
200 schema:familyName Lemmens
201 schema:givenName Edward E.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013712233607.18
203 rdf:type schema:Person
204 sg:person.0600674352.93 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
205 schema:familyName Schoenberger
206 schema:givenName Stephen P.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600674352.93
208 rdf:type schema:Person
209 sg:pub.10.1023/a:1025319031417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033012895
210 https://doi.org/10.1023/a:1025319031417
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/87730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018365256
213 https://doi.org/10.1038/87730
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/nature01441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038925353
216 https://doi.org/10.1038/nature01441
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/ni1105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002688434
219 https://doi.org/10.1038/ni1105
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nri1184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037702320
222 https://doi.org/10.1038/nri1184
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/sj.cdd.4401138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013101769
225 https://doi.org/10.1038/sj.cdd.4401138
226 rdf:type schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1081732150 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1083332919 schema:CreativeWork
229 https://doi.org/10.1002/(sici)1521-4141(199809)28:09<2714::aid-immu2714>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044389785
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0022-1759(94)90236-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041861549
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0092-8674(91)90362-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028488714
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/1074-7613(95)90057-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012226119
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s1074-7613(02)00502-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021790463
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1046/j.1600-6135.2003.00246.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015154154
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.271.22.12687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037131813
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1074/jbc.272.41.25417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050349376
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1074/jbc.m208167200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005728757
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1084/jem.182.6.1973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043714315
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1084/jem.185.12.2043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008642047
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1093/emboj/16.17.5386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028431262
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1126/science.1072615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446627
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1126/science.1082305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447916
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1126/science.1083317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448008
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1126/science.277.5327.815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557614
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1128/mcb.23.21.7638-7647.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049411262
262 rdf:type schema:CreativeWork
263 https://doi.org/10.4049/jimmunol.168.3.1356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033991928
264 rdf:type schema:CreativeWork
265 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
266 schema:name Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.185006.a schema:alternateName La Jolla Institute For Allergy & Immunology
269 schema:name Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.214572.7 schema:alternateName University of Iowa
272 schema:name Department of Urology, The Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa 52242, USA
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...