Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-12

AUTHORS

Trude H. Flo, Kelly D. Smith, Shintaro Sato, David J. Rodriguez, Margaret A. Holmes, Roland K. Strong, Shizuo Akira, Alan Aderem

ABSTRACT

Although iron is required to sustain life, its free concentration and metabolism have to be tightly regulated. This is achieved through a variety of iron-binding proteins including transferrin and ferritin. During infection, bacteria acquire much of their iron from the host by synthesizing siderophores that scavenge iron and transport it into the pathogen. We recently demonstrated that enterochelin, a bacterial catecholate siderophore, binds to the host protein lipocalin 2 (ref. 5). Here, we show that this event is pivotal in the innate immune response to bacterial infection. Upon encountering invading bacteria the Toll-like receptors on immune cells stimulate the transcription, translation and secretion of lipocalin 2; secreted lipocalin 2 then limits bacterial growth by sequestrating the iron-laden siderophore. Our finding represents a new component of the innate immune system and the acute phase response to infection. More... »

PAGES

917

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature03104

DOI

http://dx.doi.org/10.1038/nature03104

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030958858

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15531878


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