Stromal fibroblasts in cancer initiation and progression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-11

AUTHORS

Neil A Bhowmick, Eric G Neilson, Harold L Moses

ABSTRACT

It is widely accepted that the development of carcinoma--the most common form of human cancer--is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications. More... »

PAGES

332-337

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature03096

DOI

http://dx.doi.org/10.1038/nature03096

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051657854

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15549095


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