High-resolution structure of a retroviral capsid hexameric amino-terminal domain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-09

AUTHORS

Gulnahar B. Mortuza, Lesley F. Haire, Anthony Stevens, Stephen J. Smerdon, Jonathan P. Stoye, Ian A. Taylor

ABSTRACT

Retroviruses are the aetiological agents of a range of human diseases including AIDS and T-cell leukaemias. They follow complex life cycles, which are still only partly understood at the molecular level. Maturation of newly formed retroviral particles is an essential step in production of infectious virions, and requires proteolytic cleavage of Gag polyproteins in the immature particle to form the matrix, capsid and nucleocapsid proteins present in the mature virion. Capsid proteins associate to form a dense viral core that may be spherical, cylindrical or conical depending on the genus of the virus. Nonetheless, these assemblies all appear to be composed of a lattice formed from hexagonal rings, each containing six capsid monomers. Here, we describe the X-ray structure of an individual hexagonal assembly from N-tropic murine leukaemia virus (N-MLV). The interface between capsid monomers is generally polar, consistent with weak interactions within the hexamer. Similar architectures are probably crucial for the regulation of capsid assembly and disassembly in all retroviruses. Together, these observations provide new insights into retroviral uncoating and how cellular restriction factors may interfere with viral replication. More... »

PAGES

481

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature02915

DOI

http://dx.doi.org/10.1038/nature02915

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042418805

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15386017


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